Metabolism and Systems Research
Organisational unit: School
Research Projects
IMPC: Investigation into the function of pyrroline 5-carboxylate reductase 1 (PYCR1) in metabolic homeostasis
MEDICAL RESEARCH COUNCIL
1/02/18 → 31/01/20
Project: Research Councils
Pseudohypoxia-led identification of metabolic vulnerabilities in hypoxic tumours to improve patient outcomes
Daniel Tennant, Christian Ludwig & Fabian Spill
Cancer Research UK
1/02/18 → 31/01/24
Project: Research
Repairing DNA damage in a quiet genome
Christopher McCabe & Grant Stewart
Cancer Research UK
5/01/18 → 30/09/19
Project: Research
Selective CYP11B1 inhibtors as a novel treatment option for endogenous cortisol excess
MEDICAL RESEARCH COUNCIL
4/01/18 → 3/11/21
Project: Research Councils
Defects in Calcium-Sensing Receptor Plasma Membrane Expression Account for the Hypoparathyroidism Observed in Mitochondrial Disease
ODENSE UNIVERSITY HOSPITAL
1/01/18 → 31/12/19
Project: EU
Determining the effects of bariatric surgery on GLP-1 and ICP in IIH patients
MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND
1/01/18 → 31/12/21
Project: Research
The role of adipose tissue in IIH
MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND
1/01/18 → 31/12/21
Project: Research
The role of androgens in regulating ICP
MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND
1/01/18 → 31/12/21
Project: Research
The role of glucogen-like peptide 1 in neuroprotection
MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND
1/01/18 → 31/12/21
Project: Research
Using solid state telemetry to assess the intracranial pressure lowering effects of exendin-4 in an experimental model of traumatic hydrocephalus
THE RAMC CHARITY(ROYAL ARMY MEDICAL CORPS)
1/01/18 → 31/12/21
Project: Research
WT ISSF 3 - High-Speed Tracer Analysis of Metabolism (HS-TrAM)
THE WELLCOME TRUST
1/01/18 → 30/04/19
Project: Research
Are synovitis-associated IncRNAs central regulators of inflammatory pain in patients with knee OA: A route to identifying a novel analgesic drug for OA patients
ARTHRITIS RESEARCH UK
1/11/17 → 30/09/22
Project: Research
Identifying New-born and Maternal Factors contributing to increased susceptibility to infection in neonates
BIRMINGHAM CHILDRENS HOSPITAL
1/11/17 → 31/10/19
Project: Research
Assesment of the role of Yes-associated protein (YAP) in paediatric high grade glioma
BIRMINGHAM CHILDRENS HOSPITAL RESEARCH FOUNDATION
1/10/17 → 30/09/18
Project: Research
The metabolome of human adipose tissue - collaboration initiation visit
BIOSCIENTIFICA TRUST
1/10/17 → 31/03/18
Project: Research
Urine Steroid Metabolomics as an ultra-rapid test for the differential diagnosis of adrenal tumours
UHB CHARITABLE FUNDS
1/10/17 → 30/09/18
Project: Research
Validation of peptidyl arginine deiminase 2(PADI2) as a therapeutic in multiple myeloma
Cancer Research UK
1/10/17 → 30/04/20
Project: Research
Tommy's Reproductive Health Biobank
MEDICAL RESEARCH COUNCIL
29/09/17 → 28/03/21
Project: Research Councils
HWB-NMR: a national resource for biomolecular research
Daniel Tennant, Stephen Young, Gareth Lavery, Andrew Peet, Christian Ludwig, Klaus Futterer, Ulrich Gunther, David Adams, Ian Henderson & Benjamin Willcox
THE WELLCOME TRUST
25/09/17 → 24/09/22
Project: Research
Mechanisms of inflammatory disease 4 year PhD Programme - student: Alex Wilkinson
Zania Stamataki, David Hodson & David Wraith
THE WELLCOME TRUST
25/09/17 → 24/09/21
Project: Research
Mechanisms of inflammatory disease 4 year PhD Programme - student: Claire Martin
Andrew R. Clark, Rowan Hardy & Martin Hewison
THE WELLCOME TRUST
25/09/17 → 24/09/21
Project: Research
WT ISSF 3 2016 - K Manolopoulos - Career Development Hub Critical Data Award
THE WELLCOME TRUST
1/09/17 → 31/08/18
Project: Research
Unravelling the steroid metabolome in ovarian cancer to improve early diagnosis and therapy
Warwick Dunn, Sudha Sundar, Paul Foster & Wiebke Arlt
WELLBEING OF WOMEN
8/08/17 → 30/09/20
Project: Research
Optimized derivatization and LC-MS/MS method for analysis of 1a, 25-dilhydroxyvitamin D3
ANALYTICAL CHEMISTRY TRUST FUND
3/07/17 → 25/08/17
Project: Research
A New Molecular Switch in Thyroid Cancer
AMERICAN THYROID ASSOCIATION
1/07/17 → 31/12/20
Project: Research
NIHR Global Health Research unit- JAN 2017
David Lissauer, Sudha Sundar, Peter Brocklehurst, Tracy Roberts, Thomas Pinkney, Dion Morton & Aneel Bhangu
NIHR CENTRAL COMMISSIONING FACILITY
1/07/17 → 30/09/21
Project: Other Government Departments
Hydrocortisone tablets: Human factors in manipulation and their impact on dosing accuracy in paediatric populations
SOCIETY FOR ENDOCRINOLOGY
26/06/17 → 4/09/17
Project: Research
A New Molecular Switch in Thyroid Cancer
SOCIETY FOR ENDOCRINOLOGY
19/06/17 → 28/08/17
Project: Research
Derivatisation to improve Sensitivity to Steroids by LC-MS/MS
ANALYTICAL CHEMISTRY TRUST FUND
12/06/17 → 11/08/17
Project: Research
A randomised controlled trial of a Sythetic Osmotic cervical dilator for induction of Labour in comparison to dinoprostone Vaginal insErt (SOLVE)
MEDICEM INTERNATIONAL CR
1/06/17 → 31/05/19
Project: EU
Vaginal Preparation at caesarean section to Reduce Endometriosis and Prevent Sepsis (PREPS)
Victoria Ann Morton, R. Katie Morris, David Lissauer & Lee Middleton
NIHR CENTRAL COMMISSIONING FACILITY
1/06/17 → 31/08/18
Project: Other Government Departments
Development of a novel biomarker of tumour development in SDHB-mutated patients using in vivo metabolic tracing
STIFTELSEN THE PARADIFFERENCE FOUNDATION
1/05/17 → 30/04/20
Project: EU
Early Miscarriage Research Centre - WP12B - Lived experience of women, partners and families
Adam Devall, Arri Coomarasamy & Laura Jones
TOMMY'S
1/04/17 → 31/03/19
Project: Research
NIHR Biomedical Research Centre (BRC) - Sarcopaenia Theme
Janet Lord, Carolyn Greig, Leigh Breen, Gareth Lavery & Wiebke Arlt
NIHR CENTRAL COMMISSIONING FACILITY
1/04/17 → 31/03/22
Project: Other Government Departments
Tommys Early Miscarriage Research Centre - WP8 - Immune Phenotypes
Arri Coomarasamy, Mark Kilby, Paul Moss, Mark Drayson, David Lissauer & Ioannis Gallos
TOMMY'S
1/04/17 → 31/03/19
Project: Research
Miscarriage and Global Health Research
BIRMINGHAM WOMENS NHS TRUST
1/03/17 → 28/02/23
Project: Research
A randomised trial of mifepristone and misoprostol alone in the medical management of missed miscarriage: The MIFEMISO Trial
Adam Devall, Lee Middleton, Arri Coomarasamy, Tracy Roberts & Laura Jones
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/02/17 → 31/07/20
Project: Other Government Departments
Neuro-developmental Outcomes in Silver-Russell Syndrome
CHILD GROWTH FOUNDATION
1/02/17 → 31/12/19
Project: Research
Towards a new understanding of recurrent thyroid cancer
Christopher McCabe, Hisham Mehanna & Jean-Baptiste Cazier
MIDLAND INSTITUTE OF OTORHINOLARYNGOLOGY
1/01/17 → 31/12/17
Project: Research
Charaterising the transcriptome of adipose tissue in idiopathic intracranial hypertension patients to futher the understanding of idiopathic intracranial hypertenision pathogenesis.
Alex Sinclair & Hannah Botfield
MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND
1/12/16 → 30/11/18
Project: Research
Re-Engineering Radioiodine Therapy for the 21st Century
Vicki Smith, Christopher McCabe & Kristien Boelaert
MEDICAL RESEARCH COUNCIL
1/12/16 → 30/11/20
Project: Research Councils
Use of Exendin-4 in IIH, Hydrocephalus and Trauma
Alex Sinclair & Hannah Botfield
MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND
1/12/16 → 30/11/18
Project: Research
Risk of Second Brain Tumours in Patients with Pituitary Adenomas and Craniopharyngiomas treated by radiotherapy
PFIZER LIMITED
20/11/16 → 31/12/20
Project: Industry
Targeting Steroid Sulphation Pathways - A Society for Endocrinology Themed Scientific Meeting
Paul Foster & Jonathan Wolf Mueller
SOCIETY FOR ENDOCRINOLOGY
1/11/16 → 30/11/17
Project: Research
Towards a new understanding of recurrent thyroid cancer
Christopher McCabe, Jean-Baptiste Cazier & Hisham Mehanna
ROYAL COLLEGE OF SURGEONS
7/10/16 → 6/10/17
Project: Research
Ultra-performance convergence chromatography tandem mass spectrometry (UPC2-MS/MS) for steroid analyses: bridging the gap between GC-MS and LC-MS/MS
THE ACADEMY OF MEDICAL SCIENCES
1/10/16 → 30/03/20
Project: Research
MRC CIC 4 -Rescuing age-associated declines in skeletal muscle metabolism through the NAD+ precursor Nicotinamide Riboside
MEDICAL RESEARCH COUNCIL
1/09/16 → 31/12/17
Project: Research Councils
The impact of obstructive sleep apnoea treatment on microvascular complications in patients with type 2 diabetes: A feasibility study
NIHR
1/08/16 → 31/07/20
Project: Other Government Departments
The role of GLP-1 agonists in CSF pressure and neuroprotection following Traumatic Brain Injury
ROYAL CENTRE FOR DEFENCE MEDICINE
1/08/16 → 31/07/19
Project: Other Government Departments
Hydrocortisone and Congenital Hyperplasia: human factors in manipulation and their impact on dosing accuracy
DIURNAL LIMITED
7/07/16 → 6/07/17
Project: Industry
Biochemical sulfation/desulfation pathways of glucocorticoids and their role in regulatimg the inflammatory response
Jonathan Wolf Mueller & Rowan Hardy
THE BIOCHEMICAL SOCIETY
4/07/16 → 3/09/16
Project: Research
LC-MS/MS method development for the measurement of free unbound hydroxyl-vitamin D metabolites - Application to pregnancy serum samples
ANALYTICAL CHEMISTRY TRUST FUND
1/07/16 → 31/08/16
Project: Research
Metabolomics in acromegaly - Discovery of diagnostic and prognostic biomarkers in the era of personalized medicine
UHB CHARITABLE FUNDS
1/07/16 → 31/12/17
Project: Research
Rapid sperm capture: integrating live imaging and machine learning to optimise fertility treatment
Jackson Kirkman-Brown & David Smith
ENGINEERING & PHYSICAL SCIENCE RESEARCH COUNCIL
1/07/16 → 30/06/21
Project: Research Councils
Longitudinal monitoring of corticosteroid excess in adrenal incidentaloma patients by steroid metabolome profiling
SOCIETY FOR ENDOCRINOLOGY
20/06/16 → 24/08/16
Project: Research
Monitoring Vitamin D Metabolism in Human Cell Cultures
Louisa Jeffery & Martin Hewison
DR HADWEN TRUST
20/06/16 → 19/08/16
Project: Research
Effective use of care packages in global maternal health settings (CHAMPION)
BIRMINGHAM WOMENS NHS TRUST
1/06/16 → 31/05/23
Project: Research
Miscarriage and Global Health Research
Arri Coomarasamy & Jackson Kirkman-Brown
BIRMINGHAM WOMENS NHS TRUST
1/06/16 → 30/09/23
Project: Research
Miscarriage and Global Health Research
BIRMINGHAM WOMENS NHS TRUST
1/06/16 → 30/09/23
Project: Research
Biochemical sulfation/desulfation pathways of glucocorticoids and their role in regulating the inflammatory response
SOCIETY FOR ENDOCRINOLOGY
23/05/16 → 17/07/16
Project: Research
UKOSS single intrauterine fetal death in monochrionic twins study: incidence, maternal,fetal and neonatal consequences
Mark Kilby, R. Katie Morris & Fiona Mackie
BRITISH MATERNAL & FETAL MEDICINE SOCIETY
1/05/16 → 28/02/19
Project: Research
WT ISSF 15/16 - Defining novel mechanisms by which the oxygen sensor, PHD3, modulates cellular metabolism
THE WELLCOME TRUST
1/05/16 → 30/09/17
Project: Research
Wellcome Trust ISSF 15/16 - Skeletal muscle to pancreatic beta-cell cross talk: a novel endocrine system
Thomas Solomon, Jonathan Barlow & Parth Narendran
THE WELLCOME TRUST
1/05/16 → 30/09/17
Project: Research
GEM3: A multi-centre double-blind placebo-controlled randomised trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy
Lee Middleton & Arri Coomarasamy
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/04/16 → 30/09/19
Project: Other Government Departments
Improving outcomes in boys exposed to excess steroid hormones
Emma Webb, Nils Krone, Andrew Peet & Amanda Wood
BCH CHARITABLE FUNDS
1/04/16 → 31/03/18
Project: Research
WT ISSF 15/16 - A New Oncogenic Switch in Endocrine Cancer
THE WELLCOME TRUST
1/04/16 → 30/09/17
Project: Research
WT ISSF 15/16 - Investigating beta cell heterogeneity in the context of type 2 diabetes
THE WELLCOME TRUST
1/04/16 → 30/09/17
Project: Research
Investigation into the role of the microenvironment in gliomas
THE ROYAL SOCIETY
31/03/16 → 30/03/18
Project: Research Councils
Adjuvant Rituximab - a potential cure for the young patient with Graves' hyperthyroidism
Kristien Boelaert & Timothy Barrett
MEDICAL RESEARCH COUNCIL
1/03/16 → 30/06/20
Project: Research Councils
All-optical deconstruction of the islet wiring patterns underlying insulin secrection in health and disease
MEDICAL RESEARCH COUNCIL
1/03/16 → 31/08/19
Project: Research Councils
High Or Low Dose Syntocinon for delay in labour (HOLDS)
Andrew Ewer, Lee Middleton, Sara Kenyon & Beck Taylor
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/03/16 → 31/05/19
Project: Other Government Departments
Implementing non-invasive biochemical disease monitoring in children and young people with congenital adrenal hyperplasia
BIRMINGHAM CHILDRENS HOSPITAL RESEARCH FOUNDATION
1/03/16 → 28/02/17
Project: Research
Industry Collaborative Research Grant to fund headache nurse.
ELECTROCORE LLC
15/02/16 → 14/02/18
Project: Research
Evaluating the efficacy of candidate drugs in inhibiting CSF secretion
Alex Sinclair & Hannah Botfield
MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND
1/02/16 → 31/01/18
Project: Research
Graft function following HMP - Tom Smith
Christian Ludwig, Daniel Tennant &
UHB CHARITABLE FUNDS
1/02/16 → 31/01/19
Project: Research
Mechanisms Affecting the Gut of Preterm Infants in Enteral feeding trials (MAGPIE)
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/02/16 → 30/09/19
Project: Other Government Departments
Beta-aminoisobutyrate: a skeletal muscle-derived metabolite that regulates insulin secretory function
Gareth Wallis, Parth Narendran, Konstantinos Manolopoulos, Warwick Dunn &
EUROPEAN FOUNDATION FOR THE STUDY OF DIABETES
1/01/16 → 31/12/18
Project: EU
Characterising the Androgen Metabolic Signature in IIH
Alex Sinclair, Wiebke Arlt & Michael O'reilly
MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND
1/01/16 → 31/12/17
Project: Research
In situ imaging of beta cell function in mice deleted for type 2 diabeties-associated genes
DIABETES UK
1/01/16 → 31/12/18
Project: Research
Design processes based on human development for additive manufacturing
Duncan Shepherd, Moataz Attallah, Daniel Espino & Jackson Kirkman-Brown
ENGINEERING & PHYSICAL SCIENCE RESEARCH COUNCIL
1/12/15 → 30/09/17
Project: Research Councils
Equipment funding for IIH weight trials
MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND
1/12/15 → 30/09/19
Project: Research
Graft function following HMP - Jay Nath
Christian Ludwig, Daniel Tennant &
UHB CHARITABLE FUNDS
1/12/15 → 31/12/17
Project: Research
quids - Quantitative Fibronectin to help decision making in women with symptoms of preterm labour
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/12/15 → 31/05/18
Project: Other Government Departments
Novel biomarkers in recurrent thyroid cancer
Christopher McCabe, Hannah Nieto & Martin Read
GET A HEAD CHARITABLE TRUST
7/10/15 → 30/03/17
Project: Research
Investigating brain cancer metabolism for better diagnosis
HELP HARRY HELP OTHERS
1/10/15 → 30/11/18
Project: Research
Surgical Evacuation of Miscarriage with and without Intraoperative Ultrasound: a Programme of Research
NIHR TRAINEES COORDINATING CENTRE
1/10/15 → 30/09/20
Project: Other Government Departments
A novel animal model to explore the whole organism response to 21-hydroxylase deficiency
SOCIETY FOR ENDOCRINOLOGY
1/09/15 → 31/08/16
Project: Research
Pakistan Prevention Programme for Gestational Diabetes Mellitus (PPP-GDM): a feasibility study
Paramjit Gill, Arri Coomarasamy, Sheila Greenfield, Cristina Penaloza, Andrea Roalfe, Tracy Roberts & G Neil Thomas
MEDICAL RESEARCH COUNCIL
1/09/15 → 31/12/17
Project: Research Councils
Sphingosine-1-phosphate and Vitamin D as modifiable essential mediators of human placental development
MEDICAL RESEARCH COUNCIL
1/09/15 → 31/08/18
Project: Research Councils