Journal of Medicinal Chemistry, ‎0022-2623

Journal

Publications

  1. 2021
  2. Published

    Discovery of novel thiophene-arylamide derivatives as DprE1 inhibitors with potent antimycobacterial activities

    Sarah Batt, , , , , , Del Besra & , 13 May 2021, In: Journal of Medicinal Chemistry. 64, 9, p. 6241-6261 21 p.

    Research output: Contribution to journalArticlepeer-review

  3. 2020
  4. E-pub ahead of print
  5. Published
  6. 2019
  7. Published
  8. Published
  9. 2018
  10. Published
  11. Published

    Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a g-quadruplex-binding small molecule

    Jeremy Pike & 3 others, , & , 22 Mar 2018, In: Journal of Medicinal Chemistry. 61, 6, p. 2500-2517 18 p.

    Research output: Contribution to journalArticlepeer-review

  12. Published
  13. Published

    BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease

    Giovanni Bottegoni, & , 8 Feb 2018, In: Journal of Medicinal Chemistry. 61, 3, p. 619-637 19 p.

    Research output: Contribution to journalReview articlepeer-review

  14. 2017
  15. E-pub ahead of print

    Quinazolinone-based Anticancer Agents: Synthesis, Anti-proliferative SAR, Anti-tubulin Activity and Tubulin Co-crystal Structure

    Paul Foster, , , , , , , & , 11 Dec 2017, (E-pub ahead of print) In: Journal of Medicinal Chemistry.

    Research output: Contribution to journalArticlepeer-review

  16. E-pub ahead of print

    The ProTide Prodrug Technology: From the Concept to the Clinic

    Youcef Mehellou & , 9 Aug 2017, (E-pub ahead of print) In: Journal of Medicinal Chemistry.

    Research output: Contribution to journalArticlepeer-review

  17. Published
  18. Published

    Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy

    Melanie Madhani, 13 Apr 2017, In: Journal of Medicinal Chemistry. 60, 7, p. 2780-2789

    Research output: Contribution to journalArticlepeer-review

  19. Published
  20. 2016
  21. E-pub ahead of print

    Nucleoside Phosphate and Phosphonate Prodrug Clinical Candidates

    Peter Thornton, Hachemi Kadri, & Youcef Mehellou, 25 Aug 2016, (E-pub ahead of print) In: Journal of Medicinal Chemistry.

    Research output: Contribution to journalArticlepeer-review

  22. Published

    Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times

    Giovanni Bottegoni, & , 11 Aug 2016, In: Journal of Medicinal Chemistry. 59, 15, p. 7167-7176 10 p.

    Research output: Contribution to journalArticlepeer-review

  23. Published

    Exploiting protein conformational change to optimize adenosine-derived inhibitors of HSP70

    Alan M Jones, , , , , , & , 26 May 2016, In: Journal of Medicinal Chemistry. 59, 10, p. 4625-4636 12 p.

    Research output: Contribution to journalArticlepeer-review

  24. Published
  25. Published

    Role of Molecular Dynamics and Related Methods in Drug Discovery

    Giovanni Bottegoni & , 12 May 2016, In: Journal of Medicinal Chemistry. 59, 9, p. 4035-4061 27 p.

    Research output: Contribution to journalReview articlepeer-review

  26. Published

    Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors

    Giovanni Bottegoni, & , 28 Jan 2016, In: Journal of Medicinal Chemistry. 59, 2, p. 531-544 14 p.

    Research output: Contribution to journalArticlepeer-review

  27. 2015
  28. Published

    Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation

    Isolda Romero-Canelón, & , 8 Oct 2015, In: Journal of Medicinal Chemistry. 58, 19, p. 7874-7880

    Research output: Contribution to journalArticlepeer-review

  29. 2014
  30. Published
  31. Published

    Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor

    Sam Butterworth & 16 others, , , , , , , , , , , , , , , & , 1 Oct 2014, In: Journal of Medicinal Chemistry. 57, 20, p. 8249-8267 19 p.

    Research output: Contribution to journalArticlepeer-review

  32. Published
  33. 2011
  34. Published

    Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases

    Rebecca Hall, , , , & , 24 Mar 2011, In: Journal of Medicinal Chemistry. 54, 6, p. 1682-92 11 p.

    Research output: Contribution to journalArticlepeer-review

  35. 2010
  36. Published

    Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?

    Youcef Mehellou & , 28 Jan 2010, In: Journal of Medicinal Chemistry. 53, 2, p. 521-38 18 p.

    Research output: Contribution to journalArticlepeer-review

  37. 2008
  38. Published

    DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media

    Anna Peacock, & , 26 Jun 2008, In: Journal of Medicinal Chemistry. 51, 12, p. 3635-3643 9 p.

    Research output: Contribution to journalArticle

  39. Published
  40. Published

    Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents

    Paul Foster, , , , , , , , & , 2008, In: Journal of Medicinal Chemistry. 51, 5, p. 1295-308 14 p.

    Research output: Contribution to journalArticlepeer-review

  41. 2006
  42. Published
  43. Published
  44. 2005
  45. Published

    Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency

    2005, In: Journal of Medicinal Chemistry. 48, 10, p. 3504-15 12 p.

    Research output: Contribution to journalArticlepeer-review

  46. 2003
  47. Published

    Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy

    Peter Searle & Eva Hyde, 6 Nov 2003, In: Journal of Medicinal Chemistry. 46, 23, p. 4818-4821 4 p.

    Research output: Contribution to journalArticlepeer-review

  48. 1999
  49. Published

    Self-organizing molecular field analysis: A tool for structure-activity studies

    Peter Winn, & , 25 Feb 1999, In: Journal of Medicinal Chemistry. 42, 4, p. 573-583 11 p.

    Research output: Contribution to journalArticlepeer-review

  50. 1996
  51. Published
  52. 1995
  53. Published

    A Molecular dymanics approach to receptor mapping: Application to the 5HT and β-adrenergic receptors

    Peter Winn & , 1 Jan 1995, In: Journal of Medicinal Chemistry. 38, 20, p. 4080-4086 7 p.

    Research output: Contribution to journalArticlepeer-review