%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Paul A. Roberts, Ryan M. Huebinger, Emma Keen, Anne-Marie Krachler, Sara Jabbari
Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds
www.ploscompbiol.org
www.ploscompbiol.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 12 0 R/Contents 13 0 R/TrimBox[0 0 612 792]>>
endobj
12 0 obj
[14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R]
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref001)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref002)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref004)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref005)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref006)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref007)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref008)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref009)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref011)>>
endobj
25 0 obj
<>/Border[0 0 0]/A 29 0 R>>
endobj
29 0 obj
<>
endobj
26 0 obj
<>/Border[0 0 0]/A 30 0 R>>
endobj
30 0 obj
<>
endobj
27 0 obj
<>/Border[0 0 0]/A 31 0 R>>
endobj
31 0 obj
<>
endobj
28 0 obj
<>/Border[0 0 0]/A 32 0 R>>
endobj
32 0 obj
<>
endobj
13 0 obj
[33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R]
endobj
33 0 obj
<>stream
q
0.955 g
0 w
199.9998 713.9999 m
575.9997 713.9999 l
575.9997 488.0004 l
199.9998 488.0004 l
f*
0.83 0.64 0.02 0 k
438.1228 328.9323 m
442.885 328.9323 l
h
f*
427.6913 263.9055 m
432.4535 263.9055 l
h
f*
517.0961 237.9402 m
521.8583 237.9402 l
h
f*
526.2803 237.9402 m
531.0425 237.9402 l
h
f*
231.9307 211.9181 m
236.6362 211.9181 l
h
f*
241.115 211.9181 m
245.8772 211.9181 l
h
f*
542.4378 172.9134 m
547.1433 172.9134 l
h
f*
317.4236 133.9087 m
322.1858 133.9087 l
h
f*
326.6646 133.9087 m
331.4268 133.9087 l
h
f*
364.8756 107.9433 m
369.6378 107.9433 l
h
f*
374.7969 107.9433 m
384.3213 107.9433 l
h
f*
0 g
1 j
1 J
11.9999 0 0 11.9999 209.9905 696.0188 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Author)Tj
3.137 0 Td
(summary)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 209.9905 677.9905 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Humankind)Tj
5.159 0 Td
(is)Tj
0.8447 0 Td
(engaged)Tj
3.5093 0 Td
(in)Tj
1.0374 0 Td
(an)Tj
1.2019 0 Td
(arms)Tj
2.2054 0 Td
(race;)Tj
2.0976 0 Td
(one)Tj
1.7008 0 Td
(we)Tj
1.3266 0 Td
(are)Tj
1.4513 0 Td
(in)Tj
1.0318 0 Td
(danger)Tj
2.9934 0 Td
(of)Tj
1.0148 0 Td
(losing.)Tj
2.8403 0 Td
(Since)Tj
2.3584 0 Td
(the)Tj
1.4683 0 Td
(develop-)Tj
-32.241 -1.2982 Td
(ment)Tj
2.313 0 Td
(and)Tj
1.7291 0 Td
(application)Tj
4.6772 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(first)Tj
1.8028 0 Td
(antibiotics,)Tj
4.6261 0 Td
(resistant)Tj
3.583 0 Td
(strains)Tj
2.8629 0 Td
(of)Tj
1.0148 0 Td
(bacteria)Tj
3.3733 0 Td
(have)Tj
2.0636 0 Td
(steadily)Tj
-30.5346 -1.2983 Td
(emerged.)Tj
3.9004 0 Td
(As)Tj
1.2642 0 Td
(the)Tj
1.4684 0 Td
(rate)Tj
1.7518 0 Td
(of)Tj
1.0148 0 Td
(discovery)Tj
4.0081 0 Td
(of)Tj
1.0148 0 Td
(new)Tj
1.8766 0 Td
(antibiotics)Tj
4.3993 0 Td
(slows,)Tj
2.6022 0 Td
(the)Tj
1.474 0 Td
(threat)Tj
2.5682 0 Td
(increases.)Tj
4.0592 0 Td
(At)Tj
1.2018 0 Td
(present,)Tj
-32.6038 -1.3039 Td
(700,000)Tj
3.2995 0 Td
(individuals)Tj
4.6487 0 Td
(globally)Tj
3.3279 0 Td
(die)Tj
1.44 0 Td
(each)Tj
2.0239 0 Td
(year)Tj
1.9049 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0261 0 Td
(antimicrobial)Tj
5.6069 0 Td
(resistance)Tj
4.1329 0 Td
(and)Tj
1.7291 0 Td
(this)Tj
1.6781 0 Td
(number)Tj
-32.5188 -1.2983 Td
(is)Tj
0.8503 0 Td
(predicted)Tj
3.9969 0 Td
(to)Tj
1.0261 0 Td
(rise)Tj
1.6441 0 Td
(to)Tj
1.0261 0 Td
(10)Tj
1.1679 0 Td
(million)Tj
3.1237 0 Td
(per)Tj
1.5307 0 Td
(year)Tj
1.9049 0 Td
(by)Tj
1.1849 0 Td
(2050)Tj
2.1203 0 Td
(unless)Tj
2.6872 0 Td
(fresh)Tj
2.194 0 Td
(action)Tj
2.6986 0 Td
(is)Tj
0.8447 0 Td
(taken.)Tj
2.6475 0 Td
(It)Tj
0.8561 0 Td
(is)Tj
0.8504 0 Td
(impor-)Tj
-32.3544 -1.2982 Td
(tant,)Tj
2.0239 0 Td
(therefore,)Tj
4.0818 0 Td
(that)Tj
1.7802 0 Td
(we)Tj
1.3266 0 Td
(explore)Tj
3.1748 0 Td
(alternative)Tj
4.4163 0 Td
(treatment)Tj
4.1386 0 Td
(strategies)Tj
3.9231 0 Td
(to)Tj
1.0261 0 Td
(replace)Tj
3.0558 0 Td
(or)Tj
1.0998 0 Td
(complement)Tj
-30.047 -1.3039 Td
(traditional)Tj
4.422 0 Td
(antimicrobials.)Tj
6.1965 0 Td
(Here)Tj
2.2053 0 Td
(we)Tj
1.3266 0 Td
(use)Tj
1.5307 0 Td
(mathematical)Tj
5.6466 0 Td
(models)Tj
3.1067 0 Td
(to)Tj
1.0262 0 Td
(explain)Tj
3.1181 0 Td
(and)Tj
1.7348 0 Td
(predict)Tj
3.0444 0 Td
(the)Tj
-33.3579 -1.2983 Td
(effects)Tj
2.7269 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(novel)Tj
2.4038 0 Td
(anti-adhesion)Tj
5.7146 0 Td
(therapy)Tj
3.2428 0 Td
(applied)Tj
3.1578 0 Td
(to)Tj
1.0205 0 Td
(infected)Tj
3.4242 0 Td
(burn)Tj
2.1713 0 Td
(wounds.)Tj
3.6057 0 Td
(This)Tj
1.9842 0 Td
(theoreti-)Tj
-31.1185 -1.2983 Td
(cally)Tj
2.0239 0 Td
(resistance-proof)Tj
6.6727 0 Td
(therapy)Tj
3.2485 0 Td
(operates)Tj
3.5546 0 Td
(by)Tj
1.1849 0 Td
(impeding)Tj
4.0535 0 Td
(bacteria)Tj
3.3789 0 Td
(from)Tj
2.2053 0 Td
(binding)Tj
3.3505 0 Td
(to)Tj
1.0262 0 Td
(host)Tj
1.9162 0 Td
(cells)Tj
1.9162 0 Td
(by)Tj
-34.5314 -1.3039 Td
(blocking)Tj
3.6793 0 Td
(the)Tj
1.474 0 Td
(host)Tj
1.9105 0 Td
(cell)Tj
1.5591 0 Td
(binding)Tj
3.3505 0 Td
(sites.)Tj
2.16 0 Td
(This)Tj
1.9842 0 Td
(prevents)Tj
3.6227 0 Td
(bacteria)Tj
3.3732 0 Td
(from)Tj
2.211 0 Td
(accessing)Tj
3.9231 0 Td
(nutrients)Tj
3.8665 0 Td
(and)Tj
-33.1141 -1.2983 Td
(renders)Tj
3.2484 0 Td
(them)Tj
2.2904 0 Td
(susceptible)Tj
4.5751 0 Td
(to)Tj
1.0261 0 Td
(artificial)Tj
3.515 0 Td
(clearance.)Tj
4.1725 0 Td
(Fitting)Tj
2.8914 0 Td
(our)Tj
1.627 0 Td
(model)Tj
2.744 0 Td
(to)Tj
1.0261 0 Td
(experimental)Tj
5.4595 0 Td
(data,)Tj
-32.5755 -1.2982 Td
(we)Tj
1.3266 0 Td
(identify)Tj
3.2995 0 Td
(a)Tj
0.6519 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(valid)Tj
2.1486 0 Td
(parameter)Tj
4.3143 0 Td
(sets,)Tj
1.8879 0 Td
(and)Tj
1.7291 0 Td
(predict)Tj
3.0501 0 Td
(the)Tj
1.4683 0 Td
(conditions)Tj
4.4787 0 Td
(under)Tj
2.6192 0 Td
(which)Tj
-31.4076 -1.2983 Td
(treatment)Tj
4.1385 0 Td
(will)Tj
1.6611 0 Td
(be)Tj
1.1509 0 Td
(effective)Tj
3.5092 0 Td
(for)Tj
1.389 0 Td
(each)Tj
2.0296 0 Td
(set.)Tj
1.525 0 Td
(These)Tj
2.5682 0 Td
(predictions)Tj
4.7338 0 Td
(are)Tj
1.4457 0 Td
(experimentally)Tj
6.1625 0 Td
(testable,)Tj
3.4355 0 Td
(and)Tj
-33.749 -1.3039 Td
(could)Tj
2.4547 0 Td
(be)Tj
1.1509 0 Td
(used)Tj
2.0579 0 Td
(to)Tj
1.0262 0 Td
(guide)Tj
2.4321 0 Td
(the)Tj
1.4683 0 Td
(development)Tj
5.4085 0 Td
(and)Tj
1.7291 0 Td
(application)Tj
4.6828 0 Td
(of)Tj
1.0148 0 Td
(anti-adhesion)Tj
5.7146 0 Td
(treatments)Tj
4.4957 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
-34.6731 -1.2983 Td
(clinical)Tj
3.0784 0 Td
(setting.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 450.9921 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 433.9842 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(As)Tj
1.2642 0 Td
(we)Tj
1.3266 0 Td
(begin)Tj
2.4321 0 Td
(to)Tj
1.0261 0 Td
(lose)Tj
1.7575 0 Td
(the)Tj
1.4684 0 Td
(arms)Tj
2.2053 0 Td
(race)Tj
1.8708 0 Td
(against)Tj
3.0331 0 Td
(microbial)Tj
4.0592 0 Td
(infections,)Tj
4.3767 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8447 0 Td
(important)Tj
4.286 0 Td
(that)Tj
1.7744 0 Td
(we)Tj
1.3323 0 Td
(develop)Tj
-33.8454 -1.2982 Td
(new)Tj
1.8765 0 Td
(treatment)Tj
4.1329 0 Td
(strategies)Tj
3.9231 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(complement)Tj
5.2441 0 Td
(or)Tj
1.0998 0 Td
(alternative)Tj
4.4164 0 Td
(to)Tj
1.0261 0 Td
(antibiotics.)Tj
4.6261 0 Td
(In)Tj
1.1112 0 Td
(this)Tj
1.6724 0 Td
(paper,)Tj
2.7099 0 Td
(we)Tj
1.3266 0 Td
(use)Tj
-34.8375 -1.2983 Td
(mathematical)Tj
5.6465 0 Td
(modelling)Tj
4.269 0 Td
(to)Tj
1.0261 0 Td
(explain)Tj
3.1238 0 Td
(and)Tj
1.7291 0 Td
(predict)Tj
3.0501 0 Td
(the)Tj
1.4683 0 Td
(effects)Tj
2.7269 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(novel)Tj
2.3981 0 Td
(anti-adhesion)Tj
5.7146 0 Td
(therapy)Tj
3.2485 0 Td
(in)Tj
-36.0678 -1.3039 Td
(the)Tj
1.4683 0 Td
(treatment)Tj
4.1329 0 Td
(of)Tj
1.0204 0 Td
(infected)Tj
3.4186 0 Td
(burn)Tj
2.1713 0 Td
(wounds,)Tj
3.6057 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(aim)Tj
1.7404 0 Td
(of)Tj
1.0148 0 Td
(improving)Tj
4.4391 0 Td
(treatment)Tj
4.1385 0 Td
(outcome.)Tj
-29.4177 -1.2983 Td
(Each)Tj
2.177 0 Td
(year,)Tj
2.1316 0 Td
(millions)Tj
3.4809 0 Td
(of)Tj
1.0148 0 Td
(lives)Tj
1.9729 0 Td
(are)Tj
1.4457 0 Td
(saved)Tj
2.4208 0 Td
(through)Tj
3.4469 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5364 0 Td
(of)Tj
1.0148 0 Td
(antibiotics)Tj
4.3936 0 Td
(to)Tj
1.0262 0 Td
(combat)Tj
3.2088 0 Td
(bacterial)Tj
-31.9349 -1.2982 Td
(infections.)Tj
4.3766 0 Td
(However,)Tj
4.0762 0 Td
(sustained)Tj
3.9685 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(any)Tj
1.6611 0 Td
(given)Tj
2.3754 0 Td
(antibiotic)Tj
4.0422 0 Td
(leads)Tj
2.211 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(clinical)Tj
3.0784 0 Td
(emergence)Tj
4.541 0 Td
(of)Tj
-35.3704 -1.3039 Td
(drug-resistant)Tj
5.8223 0 Td
(strains.)Tj
3.0897 0 Td
(Since)Tj
2.3584 0 Td
(the)Tj
1.4684 0 Td
(discovery)Tj
4.0081 0 Td
(of)Tj
1.0148 0 Td
(penicillin,)Tj
4.2009 0 Td
(many)Tj
2.4775 0 Td
(new)Tj
1.8765 0 Td
(classes)Tj
2.829 0 Td
(of)Tj
1.0148 0 Td
(antibiotics)Tj
4.3993 0 Td
(have)Tj
-34.5597 -1.2983 Td
(been)Tj
2.1203 0 Td
(identified,)Tj
4.2859 0 Td
(allowing)Tj
3.617 0 Td
(clinicians)Tj
4.0082 0 Td
(to)Tj
1.0261 0 Td
(switch)Tj
2.7779 0 Td
(between)Tj
3.532 0 Td
(antibiotics)Tj
4.3993 0 Td
(if)Tj
0.771 0 Td
(resistance)Tj
4.1329 0 Td
(emerges)Tj
3.5093 0 Td
(either)Tj
-34.1799 -1.2983 Td
(within)Tj
2.8119 0 Td
(an)Tj
1.2019 0 Td
(individual)Tj
4.2859 0 Td
(patient)Tj
3.0104 0 Td
(or)Tj
1.0999 0 Td
(within)Tj
2.8119 0 Td
(a)Tj
0.652 0 Td
(patient)Tj
3.0103 0 Td
(population)Tj
4.5865 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(Over)Tj
2.2166 0 Td
(time,)Tj
2.2507 0 Td
(strains)Tj
2.863 0 Td
(have)Tj
-32.4054 -1.2982 Td
(emerged)Tj
3.6736 0 Td
(which)Tj
2.6476 0 Td
(exhibit)Tj
2.9763 0 Td
(resistance)Tj
4.1329 0 Td
(to)Tj
1.0262 0 Td
(multiple)Tj
3.5659 0 Td
(classes)Tj
2.829 0 Td
(of)Tj
1.0148 0 Td
(antibiotics)Tj
4.3993 0 Td
(\(multi-drug)Tj
4.9606 0 Td
(resistance\))Tj
4.4731 0 Td
(and)Tj
-35.6993 -1.304 Td
(reports)Tj
3.067 0 Td
(of)Tj
1.0148 0 Td
(bacterial)Tj
3.6283 0 Td
(infections)Tj
4.1499 0 Td
(which)Tj
2.6532 0 Td
(are)Tj
1.4457 0 Td
(resistant)Tj
3.583 0 Td
(to)Tj
1.0261 0 Td
(all)Tj
1.1452 0 Td
(known)Tj
3.0047 0 Td
(antibiotics)Tj
4.3993 0 Td
(\(pan-resistant\))Tj
6.1115 0 Td
(are)Tj
-35.2287 -1.2982 Td
(becoming)Tj
4.1782 0 Td
(increasingly)Tj
5.0343 0 Td
(common.)Tj
4.0705 0 Td
(At)Tj
1.2019 0 Td
(present,)Tj
3.3902 0 Td
(a)Tj
0.652 0 Td
(reported)Tj
3.6623 0 Td
(700,000)Tj
3.2939 0 Td
(individuals)Tj
4.6544 0 Td
(worldwide)Tj
4.456 0 Td
(die)Tj
-34.5937 -1.2983 Td
(each)Tj
2.0295 0 Td
(year)Tj
1.8992 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0262 0 Td
(antimicrobial)Tj
5.6125 0 Td
(resistance)Tj
4.1272 0 Td
(and)Tj
1.7348 0 Td
(this)Tj
1.6725 0 Td
(figure)Tj
2.5625 0 Td
(is)Tj
0.8447 0 Td
(predicted)Tj
4.0025 0 Td
(to)Tj
1.0261 0 Td
(rise)Tj
1.6441 0 Td
(to)Tj
1.0261 0 Td
(10)Tj
1.1679 0 Td
(million)Tj
3.1238 0 Td
(per)Tj
-35.2004 -1.3039 Td
(year)Tj
1.9048 0 Td
(by)Tj
1.1792 0 Td
(2050)Tj
2.1203 0 Td
(unless)Tj
2.6873 0 Td
(steps)Tj
2.1826 0 Td
(are)Tj
1.4513 0 Td
(taken)Tj
2.4208 0 Td
(to)Tj
1.0262 0 Td
(combat)Tj
3.2088 0 Td
(this)Tj
1.6724 0 Td
(threat)Tj
2.5738 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5988 0 Td
(While)Tj
2.6532 0 Td
(resistant)Tj
3.5829 0 Td
(strains)Tj
2.863 0 Td
(continue)Tj
-33.1254 -1.2983 Td
(to)Tj
1.0261 0 Td
(evolve,)Tj
2.9537 0 Td
(our)Tj
1.627 0 Td
(ability)Tj
2.6929 0 Td
(to)Tj
1.0262 0 Td
(develop)Tj
3.3165 0 Td
(new)Tj
1.8765 0 Td
(classes)Tj
2.829 0 Td
(of)Tj
1.0204 0 Td
(antibiotics)Tj
4.3937 0 Td
(is)Tj
0.8504 0 Td
(diminishing,)Tj
5.3121 0 Td
(the)Tj
1.4683 0 Td
(rate)Tj
1.7462 0 Td
(of)Tj
1.0148 0 Td
(antibiotic)Tj
-33.1538 -1.2982 Td
(discovery)Tj
4.0081 0 Td
(having)Tj
2.9197 0 Td
(slowed)Tj
2.9707 0 Td
(significantly)Tj
5.0853 0 Td
(since)Tj
2.245 0 Td
(its)Tj
1.1452 0 Td
(`Golden)Tj
3.4129 0 Td
(Era')Tj
1.8142 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(1940s1960s)Tj
5.261 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(3)Tj
0 g
(].)Tj
1.2643 0 Td
(It)Tj
0.856 0 Td
(is)Tj
-34.7468 -1.3039 Td
(therefore)Tj
3.855 0 Td
(vital)Tj
1.9163 0 Td
(that)Tj
1.7801 0 Td
(we)Tj
1.3266 0 Td
(develop)Tj
3.3222 0 Td
(alternative)Tj
4.4163 0 Td
(treatment)Tj
4.1386 0 Td
(strategies)Tj
3.9231 0 Td
(to)Tj
1.0262 0 Td
(replace)Tj
3.0557 0 Td
(or)Tj
1.0998 0 Td
(complement)Tj
5.2498 0 Td
(anti-)Tj
-35.1097 -1.2983 Td
(biotics)Tj
2.8516 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(5)Tj
0 g
(].)Tj
-2.914 -1.2983 Td
(One)Tj
1.9388 0 Td
(potential)Tj
3.7644 0 Td
(way)Tj
1.7915 0 Td
(forward)Tj
3.4016 0 Td
(is)Tj
0.8504 0 Td
(through)Tj
3.4469 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(anti-virulence)Tj
5.8053 0 Td
(treatments.)Tj
4.7225 0 Td
(Whereas)Tj
3.7247 0 Td
(antibi-)Tj
-34.6561 -1.3039 Td
(otics)Tj
2.0749 0 Td
(either)Tj
2.5342 0 Td
(kill)Tj
1.474 0 Td
(bacteria)Tj
3.3788 0 Td
(\(bactericidal\))Tj
5.5219 0 Td
(or)Tj
1.0998 0 Td
(inhibit)Tj
2.9027 0 Td
(their)Tj
2.109 0 Td
(growth)Tj
3.0727 0 Td
(\(bacteriostatic\),)Tj
6.4403 0 Td
(anti-virulence)Tj
-30.6083 -1.2983 Td
(treatments)Tj
4.4957 0 Td
(interfere)Tj
3.634 0 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.6577 0 Td
(pathogen's)Tj
4.5184 0 Td
(ability)Tj
2.6929 0 Td
(to)Tj
1.0261 0 Td
(cause)Tj
2.3868 0 Td
(damage)Tj
3.3278 0 Td
(and)Tj
1.7291 0 Td
(disease)Tj
3.0161 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(host)Tj
1.9162 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5987 0 Td
(As)Tj
-35.5008 -1.2982 Td
(such,)Tj
2.2847 0 Td
(they)Tj
1.9218 0 Td
(are)Tj
1.4514 0 Td
(likely)Tj
2.3527 0 Td
(to)Tj
1.0261 0 Td
(exert)Tj
2.1997 0 Td
(a)Tj
0.6576 0 Td
(smaller)Tj
3.1181 0 Td
(selective)Tj
3.5433 0 Td
(pressure)Tj
3.5773 0 Td
(upon)Tj
2.3187 0 Td
(a)Tj
0.6577 0 Td
(bacterial)Tj
3.6226 0 Td
(community,)Tj
5.1137 0 Td
(reducing)Tj
-33.8454 -1.2983 Td
(the)Tj
1.4683 0 Td
(chances)Tj
3.3619 0 Td
(that)Tj
1.7801 0 Td
(resistance)Tj
4.1272 0 Td
(will)Tj
1.6668 0 Td
(develop)Tj
3.3222 0 Td
(\(though)Tj
3.4129 0 Td
(opinions)Tj
3.7417 0 Td
(vary)Tj
1.9332 0 Td
(over)Tj
1.9786 0 Td
(the)Tj
1.4683 0 Td
(extent)Tj
2.6759 0 Td
(to)Tj
1.0261 0 Td
(which)Tj
2.6532 0 Td
(they)Tj
-34.6164 -1.3039 Td
(may)Tj
1.9275 0 Td
(be)Tj
1.1509 0 Td
(resistance-proof,)Tj
6.8994 0 Td
(see)Tj
1.423 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2643 0 Td
(8)Tj
0 g
(]\).)Tj
1.5987 0 Td
(Anti-virulence)Tj
6.0548 0 Td
(treatments)Tj
4.5014 0 Td
(take)Tj
1.8708 0 Td
(a)Tj
0.652 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(forms)Tj
2.5682 0 Td
(includ-)Tj
-34.3443 -1.2983 Td
(ing)Tj
1.5023 0 Td
(those)Tj
2.3357 0 Td
(which)Tj
2.6476 0 Td
(target)Tj
2.5115 0 Td
(or)Tj
1.0998 0 Td
(inhibit)Tj
2.9027 0 Td
(toxin)Tj
2.3073 0 Td
(activity,)Tj
3.3392 0 Td
(adhesion,)Tj
4.0422 0 Td
(toxin)Tj
2.3074 0 Td
(secretion,)Tj
4.0705 0 Td
(virulence)Tj
3.9061 0 Td
(gene)Tj
-32.9723 -1.2982 Td
(expression)Tj
4.4617 0 Td
(and)Tj
1.7347 0 Td
(inter-bacterial)Tj
5.8847 0 Td
(signalling)Tj
4.0649 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
-14.9498 -1.304 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(paper,)Tj
2.7099 0 Td
(we)Tj
1.3266 0 Td
(consider)Tj
3.651 0 Td
(a)Tj
0.6519 0 Td
(form)Tj
2.2054 0 Td
(of)Tj
1.0148 0 Td
(anti-adhesion)Tj
5.7203 0 Td
(treatment)Tj
4.1328 0 Td
(consisting)Tj
4.269 0 Td
(of)Tj
1.0148 0 Td
(polystyrene)Tj
-30.6763 -1.2982 Td
(microbeads)Tj
4.8585 0 Td
(coupled)Tj
3.3959 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(protein)Tj
3.1521 0 Td
(known)Tj
3.0047 0 Td
(as)Tj
1.0148 0 Td
(multivalent)Tj
4.7848 0 Td
(adhesion)Tj
3.8155 0 Td
(molecule)Tj
3.838 0 Td
(\(MAM\))Tj
3.3732 0 Td
(7)Tj
0.6917 0 Td
(\(see)Tj
1.7688 0 Td
(also)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 169.285 23.6976 re
W* n
q
169.2283 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 394.4125 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Predictiv)Tj
3.763 0 Td
(e)Tj
0.7653 0 Td
(modelling)Tj
4.415 0 Td
(of)Tj
1.0418 0 Td
(a)Tj
0.7653 0 Td
(novel)Tj
2.5583 0 Td
(anti-adhesion)Tj
6.1087 0 Td
(therapy)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
142.5827 34.9228 m
295.8236 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Computationa)Tj
6.1229 0 Td
(l)Tj
0.4322 0 Td
(Biology)Tj
3.4371 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https:/)Tj
2.6788 0 Td
(/doi.org/10.13)Tj
6.0094 0 Td
(71/journal.p)Tj
5.1166 0 Td
(cbi.1006071)Tj
0 g
6.3497 0 Td
(May)Tj
2.0835 0 Td
(3,)Tj
1.0417 0 Td
(2018)Tj
28.538 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(28)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
38.4378 685.6441 m
114.463 685.6441 l
h
f*
113.1024 641.6504 m
180.5669 641.6504 l
h
f*
36 630.652 m
153.9213 630.652 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F9 1 Tf
1 TL
-0.025 Tc
0 0 Td
(acknowledge)Tj
4.8331 0 Td
(s)Tj
0.6448 0 Td
(support)Tj
3.0969 0 Td
(from)Tj
2.0055 0 Td
(the)Tj
1.3749 0 Td
(Golden)Tj
2.8417 0 Td
(Charity)Tj
-14.7969 -1.3748 Td
(Guild)Tj
2.1401 0 Td
(Charles)Tj
2.9835 0 Td
(R.)Tj
1.0347 0 Td
(Baxter,)Tj
2.7921 0 Td
(MD)Tj
1.5662 0 Td
(Chair)Tj
2.1401 0 Td
(in)Tj
0.8859 0 Td
(Burn)Tj
1.9984 0 Td
(Surgery)Tj
-15.541 -1.3748 Td
(\()Tj
0.83 0.64 0.02 0 k
(www.utsouth)Tj
5.2724 0 Td
(western.edu)Tj
0 g
(\))Tj
5.0599 0 Td
(which)Tj
2.4237 0 Td
(provided)Tj
-12.756 -1.3748 Td
(research)Tj
3.4157 0 Td
(funding.)Tj
3.2599 0 Td
(AMK)Tj
2.0268 0 Td
(thanks)Tj
2.6858 0 Td
(the)Tj
1.3678 0 Td
(UT)Tj
1.2826 0 Td
(System)Tj
3.019 0 Td
(for)Tj
-17.0576 -1.3748 Td
(support)Tj
3.0968 0 Td
(through)Tj
3.1536 0 Td
(a)Tj
0.6378 0 Td
(University)Tj
3.9189 0 Td
(of)Tj
0.9496 0 Td
(Texas)Tj
2.3741 0 Td
(System)Tj
-14.1308 -1.3748 Td
(Science)Tj
3.0968 0 Td
(and)Tj
1.5874 0 Td
(Technology)Tj
4.5213 0 Td
(Acquisition)Tj
4.3158 0 Td
(and)Tj
1.5874 0 Td
(Retention)Tj
-15.1087 -1.3748 Td
(\(STARs\))Tj
3.3661 0 Td
(Program)Tj
3.4867 0 Td
(award)Tj
2.4803 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(https://w)Tj
3.5575 0 Td
(ww.utsystem.)Tj
-12.8906 -1.3748 Td
(edu/offices/h)Tj
4.7905 0 Td
(ealth-affairs/s)Tj
5.0245 0 Td
(tars-program)Tj
0 g
(\))Tj
5.23 0 Td
(.)Tj
0.4464 0 Td
(The)Tj
-15.4914 -1.3749 Td
(funders)Tj
3.0472 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6087 0 Td
(in)Tj
0.8929 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.793 0 Td
(collection)Tj
-15.2576 -1.3748 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4362 0 Td
(of)Tj
-17.8229 -1.3748 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F8 1 Tf
-1.3677 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(I)Tj
0.4748 0 Td
(have)Tj
1.956 0 Td
(read)Tj
1.8425 0 Td
(the)Tj
1.3677 0 Td
(journal's)Tj
-13.8331 -1.3748 Td
(policy)Tj
2.3952 0 Td
(and)Tj
1.5875 0 Td
(the)Tj
1.3748 0 Td
(authors)Tj
3.0402 0 Td
(of)Tj
0.9496 0 Td
(this)Tj
1.5661 0 Td
(manuscript)Tj
4.415 0 Td
(have)Tj
1.9559 0 Td
(the)Tj
-17.2843 -1.3748 Td
(following)Tj
3.5858 0 Td
(competing)Tj
4.1599 0 Td
(interests:)Tj
3.6142 0 Td
(AMK)Tj
2.0268 0 Td
(is)Tj
0.8362 0 Td
(a)Tj
0.6378 0 Td
(co-)Tj
-14.8607 -1.3748 Td
(inventor)Tj
3.2386 0 Td
(on)Tj
1.1693 0 Td
(the)Tj
1.3677 0 Td
(patent)Tj
2.5228 0 Td
(`Modula)Tj
2.9764 0 Td
(ting)Tj
1.6158 0 Td
(bacterial)Tj
3.3307 0 Td
(MAM)Tj
-16.2213 -1.3748 Td
(polypeptid)Tj
3.848 0 Td
(es)Tj
1.063 0 Td
(in)Tj
0.8929 0 Td
(pathogenic)Tj
4.2946 0 Td
(disease')Tj
3.189 0 Td
(\(US95290)Tj
3.7842 0 Td
(05,)Tj
-17.0717 -1.3749 Td
(issued)Tj
2.622 0 Td
(Dec)Tj
1.6512 0 Td
(27,)Tj
ET
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
BT
5.6693 -22.7482 Td
(2016\).)Tj
ET
Q
endstream
endobj
46 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 48 0 R/Contents 49 0 R/TrimBox[0 0 612 792]>>
endobj
48 0 obj
[50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R]
endobj
50 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref012)>>
endobj
51 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref013)>>
endobj
52 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref014)>>
endobj
53 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref015)>>
endobj
54 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref015)>>
endobj
55 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref018)>>
endobj
56 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref015)>>
endobj
57 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref019)>>
endobj
58 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref020)>>
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref021)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref020)>>
endobj
61 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref022)>>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref023)>>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref009)>>
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref024)>>
endobj
65 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref025)>>
endobj
66 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref026)>>
endobj
67 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref033)>>
endobj
68 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref034)>>
endobj
69 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref030)>>
endobj
70 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref035)>>
endobj
71 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref037)>>
endobj
72 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref038)>>
endobj
73 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref039)>>
endobj
74 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref040)>>
endobj
75 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref041)>>
endobj
76 0 obj
<>/Border[0 0 0]/Dest(Rpcbi.1006071.ref023)>>
endobj
77 0 obj
<>/Border[0 0 0]/A 78 0 R>>
endobj
78 0 obj
<>
endobj
49 0 obj
[79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R]
endobj
79 0 obj
<>stream
q
0.83 0.64 0.02 0 k
203.4142 706.337 m
212.9386 706.337 l
h
f*
222.6331 667.3323 m
232.1008 667.3323 l
h
f*
236.5795 667.3323 m
246.1039 667.3323 l
h
f*
319.011 550.3181 m
328.5354 550.3181 l
h
f*
230.5134 537.3354 m
239.9811 537.3354 l
h
f*
245.1969 537.3354 m
254.6646 537.3354 l
h
f*
295.6535 524.2961 m
305.1213 524.2961 l
h
f*
309.6 524.2961 m
319.1244 524.2961 l
h
f*
554.0598 459.326 m
563.5843 459.326 l
h
f*
524.863 446.3433 m
534.3874 446.3433 l
h
f*
400.7055 433.3039 m
410.2299 433.3039 l
h
f*
414.652 433.3039 m
424.1764 433.3039 l
h
f*
410.6268 394.2992 m
420.1512 394.2992 l
h
f*
252.2268 368.3339 m
256.989 368.3339 l
h
f*
261.4677 368.3339 m
270.9921 368.3339 l
h
f*
304.611 355.3512 m
314.1354 355.3512 l
h
f*
371.2252 316.3465 m
380.7496 316.3465 l
h
f*
385.9087 316.3465 m
395.4331 316.3465 l
h
f*
203.4142 303.3071 m
212.9386 303.3071 l
h
f*
544.6488 225.2976 m
554.1165 225.2976 l
h
f*
558.5953 225.2976 m
568.1197 225.2976 l
h
f*
200.0126 212.315 m
209.537 212.315 l
h
f*
493.852 212.315 m
503.3197 212.315 l
h
f*
394.1291 199.3323 m
403.6535 199.3323 l
h
f*
489.8268 173.3102 m
499.3512 173.3102 l
h
f*
295.3134 147.3449 m
304.8378 147.3449 l
h
f*
427.2945 82.3181 m
436.7622 82.3181 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(])Tj
1.8481 0 Td
(and)Tj
1.7348 0 Td
(other)Tj
2.3471 0 Td
(papers)Tj
2.8403 0 Td
(from)Tj
2.2053 0 Td
(their)Tj
2.109 0 Td
(group)Tj
2.6078 0 Td
(for)Tj
1.389 0 Td
(alternative)Tj
4.422 0 Td
(anti-adhesion)Tj
5.7146 0 Td
(treatments)Tj
4.4958 0 Td
(that)Tj
1.7744 0 Td
(operate)Tj
-33.4882 -1.3039 Td
(by)Tj
1.1792 0 Td
(blocking)Tj
3.6793 0 Td
(pilus)Tj
2.143 0 Td
(assembly)Tj
3.8267 0 Td
(or)Tj
1.0999 0 Td
(function\).)Tj
4.1895 0 Td
(MAM7)Tj
3.1692 0 Td
(is)Tj
0.8447 0 Td
(anchored)Tj
3.9855 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(outer)Tj
2.347 0 Td
(membrane)Tj
4.5695 0 Td
(of)Tj
1.0148 0 Td
(many)Tj
-34.5541 -1.2982 Td
(Gram-negative)Tj
6.2248 0 Td
(bacteria,)Tj
3.6056 0 Td
(where)Tj
2.6476 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8447 0 Td
(responsible)Tj
4.7565 0 Td
(for)Tj
1.3833 0 Td
(initiating)Tj
3.8835 0 Td
(attachment)Tj
4.7225 0 Td
(of)Tj
1.0148 0 Td
(bacteria)Tj
3.3788 0 Td
(to)Tj
1.0262 0 Td
(host)Tj
-34.2763 -1.2983 Td
(cells)Tj
1.9218 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(14)Tj
0 g
(].)Tj
1.7348 0 Td
(When)Tj
2.6872 0 Td
(applied)Tj
3.1521 0 Td
(to)Tj
1.0262 0 Td
(an)Tj
1.2019 0 Td
(infection)Tj
3.7927 0 Td
(site,)Tj
1.7915 0 Td
(MAM7-coated)Tj
6.1341 0 Td
(beads)Tj
2.4718 0 Td
(\(henceforth,)Tj
5.125 0 Td
(inhibitors\))Tj
-32.7739 -1.2983 Td
(act)Tj
1.3719 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(bacteriomimetic,)Tj
6.9959 0 Td
(competitively)Tj
5.6182 0 Td
(inhibiting)Tj
4.1839 0 Td
(the)Tj
1.4684 0 Td
(infectious)Tj
4.1329 0 Td
(agent)Tj
2.3924 0 Td
(from)Tj
2.2053 0 Td
(binding)Tj
3.3506 0 Td
(to)Tj
1.0261 0 Td
(host)Tj
-34.418 -1.3039 Td
(cells.)Tj
2.1429 0 Td
(This)Tj
1.9899 0 Td
(prevents)Tj
3.617 0 Td
(bacteria)Tj
3.3789 0 Td
(from)Tj
2.2053 0 Td
(deploying)Tj
4.1783 0 Td
(those)Tj
2.3357 0 Td
(virulence)Tj
3.9061 0 Td
(mechanisms)Tj
5.2044 0 Td
(for)Tj
1.389 0 Td
(which)Tj
2.6475 0 Td
(cell-to-cell)Tj
-32.995 -1.2982 Td
(contact)Tj
3.1521 0 Td
(is)Tj
0.8503 0 Td
(required)Tj
3.634 0 Td
(and)Tj
1.7348 0 Td
(renders)Tj
3.2428 0 Td
(them)Tj
2.2904 0 Td
(more)Tj
2.3414 0 Td
(susceptible)Tj
4.5751 0 Td
(to)Tj
1.0262 0 Td
(natural)Tj
3.084 0 Td
(or)Tj
1.0942 0 Td
(artificial)Tj
3.5206 0 Td
(physical)Tj
3.4469 0 Td
(clear-)Tj
-33.9928 -1.2983 Td
(ance.)Tj
2.2733 0 Td
(Given)Tj
2.6306 0 Td
(that)Tj
1.7801 0 Td
(inhibitors)Tj
4.1386 0 Td
(must)Tj
2.228 0 Td
(bind)Tj
2.0693 0 Td
(to)Tj
1.0261 0 Td
(host)Tj
1.9162 0 Td
(cells)Tj
1.9162 0 Td
(before)Tj
2.7439 0 Td
(bacteria)Tj
3.3789 0 Td
(in)Tj
1.0318 0 Td
(order)Tj
2.4208 0 Td
(to)Tj
1.0261 0 Td
(block)Tj
2.3981 0 Td
(them)Tj
2.2904 0 Td
(from)Tj
-35.2684 -1.3039 Td
(binding,)Tj
3.5773 0 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8504 0 Td
(unclear)Tj
3.1918 0 Td
(whether)Tj
3.4809 0 Td
(their)Tj
2.1033 0 Td
(application)Tj
4.6828 0 Td
(may)Tj
1.9276 0 Td
(ever)Tj
1.8935 0 Td
(be)Tj
1.1508 0 Td
(expanded)Tj
4.0876 0 Td
(from)Tj
2.2053 0 Td
(prevention)Tj
4.5808 0 Td
(\(pro-)Tj
-34.5144 -1.2983 Td
(phylaxis\))Tj
3.8324 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(treatment)Tj
4.1329 0 Td
(of)Tj
1.0148 0 Td
(established)Tj
4.5978 0 Td
(infections)Tj
4.1556 0 Td
(\(therapy\).)Tj
-19.0317 -1.2983 Td
(Bacterial)Tj
3.702 0 Td
(infection)Tj
3.787 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(major)Tj
2.6135 0 Td
(cause)Tj
2.3868 0 Td
(of)Tj
1.0148 0 Td
(mortality)Tj
3.9174 0 Td
(in)Tj
1.0375 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
1.9956 0 Td
(burn)Tj
2.177 0 Td
(wounds,)Tj
3.6 0 Td
(where)Tj
2.6475 0 Td
(it)Tj
0.7881 0 Td
(is)Tj
-35.7333 -1.3039 Td
(responsible)Tj
4.7508 0 Td
(for)Tj
1.389 0 Td
(up)Tj
1.2642 0 Td
(to)Tj
1.0261 0 Td
(75%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(deaths)Tj
2.7893 0 Td
(in)Tj
1.0374 0 Td
(cases)Tj
2.2224 0 Td
(where)Tj
2.6532 0 Td
(severe)Tj
2.6759 0 Td
(burns)Tj
2.5341 0 Td
(are)Tj
1.4514 0 Td
(sustained)Tj
3.9684 0 Td
(to)Tj
1.0262 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
-34.0722 -1.2982 Td
(40%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(body)Tj
2.2167 0 Td
(surface)Tj
3.0501 0 Td
(area)Tj
1.8822 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0749 0 Td
(Burn)Tj
2.2507 0 Td
(wounds)Tj
3.3732 0 Td
(are)Tj
1.4513 0 Td
(commonly)Tj
4.5468 0 Td
(infected)Tj
3.4185 0 Td
(by)Tj
/F11 1 Tf
1.1793 0 Td
[()18()-3()2()4()4()11()6()11()6( )]TJ
5.5672 0 Td
[( )6()2(\n)-9()]TJ
-35.4215 -1.2983 Td
[()-8(\r)12()6()7()-3( )]TJ
/F6 1 Tf
2.7099 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(],)Tj
3.5432 0 Td
(an)Tj
1.2019 0 Td
(opportunistic)Tj
5.6296 0 Td
(Gram-negative)Tj
6.2305 0 Td
(bacterium;)Tj
4.5127 0 Td
(the)Tj
1.474 0 Td
(infection)Tj
3.7871 0 Td
(often)Tj
2.2904 0 Td
(being)Tj
2.4264 0 Td
(hospital-)Tj
-33.8057 -1.3039 Td
(acquired)Tj
3.702 0 Td
(\(nosocomial\))Tj
5.5218 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(19)Tj
0 g
(].)Tj
-9.7624 -1.2983 Td
(Current)Tj
3.4242 0 Td
(treatment)Tj
4.1385 0 Td
(of)Tj
1.0148 0 Td
(such)Tj
2.058 0 Td
(infections)Tj
4.1556 0 Td
(involves)Tj
3.4809 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(topical)Tj
2.914 0 Td
(and)Tj
1.7291 0 Td
(systemic)Tj
3.634 0 Td
(antibiotics,)Tj
4.6204 0 Td
(and)Tj
-34.9112 -1.2982 Td
(regular)Tj
3.0557 0 Td
(debridement)Tj
5.3631 0 Td
(\(mechanical)Tj
5.1023 0 Td
(wound)Tj
3.0161 0 Td
(cleaning\).)Tj
4.1442 0 Td
(Debridement)Tj
5.5672 0 Td
(is)Tj
0.8447 0 Td
(either)Tj
2.5342 0 Td
(achieved)Tj
3.702 0 Td
(through)Tj
-33.3295 -1.2983 Td
(regular)Tj
3.05 0 Td
(wound)Tj
3.0104 0 Td
(cleansing)Tj
3.9288 0 Td
(with)Tj
1.9899 0 Td
(a)Tj
0.6463 0 Td
(cloth,)Tj
2.4434 0 Td
(or)Tj
1.0885 0 Td
(through)Tj
3.4356 0 Td
(application)Tj
4.6771 0 Td
(of)Tj
1.0035 0 Td
(negative)Tj
3.5319 0 Td
(pressure)Tj
3.566 0 Td
(devices)Tj
3.0954 0 Td
(\(neg-)Tj
-35.4668 -1.3039 Td
(ative)Tj
2.0862 0 Td
(pressure)Tj
3.566 0 Td
(wound)Tj
3.0047 0 Td
(therapy,)Tj
3.4639 0 Td
(NPWT\))Tj
3.4242 0 Td
(in)Tj
1.0262 0 Td
(which)Tj
2.6362 0 Td
(fluid)Tj
2.0693 0 Td
(is)Tj
0.839 0 Td
(drawn)Tj
2.7723 0 Td
(out)Tj
1.5477 0 Td
(of)Tj
1.0034 0 Td
(the)Tj
1.457 0 Td
(wound,)Tj
3.2315 0 Td
(either)Tj
2.5228 0 Td
(contin-)Tj
-34.6504 -1.2983 Td
(uously)Tj
2.8402 0 Td
(or)Tj
1.0999 0 Td
(intermittently,)Tj
6.0094 0 Td
(using)Tj
2.3924 0 Td
(a)Tj
0.652 0 Td
(pump,)Tj
2.8289 0 Td
(attached)Tj
3.583 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.6577 0 Td
(foam)Tj
2.2677 0 Td
(dressing)Tj
3.5433 0 Td
(covering)Tj
3.6793 0 Td
(the)Tj
1.474 0 Td
(wound)Tj
3.0161 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
-35.07 -1.2983 Td
(Some)Tj
2.4434 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.0579 0 Td
(shown)Tj
2.8517 0 Td
(NPWT)Tj
3.0897 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(effective)Tj
3.5093 0 Td
(in)Tj
1.0375 0 Td
(reducing)Tj
3.7757 0 Td
(the)Tj
1.4683 0 Td
(bacterial)Tj
3.6227 0 Td
(burden)Tj
3.1237 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(];)Tj
2.0806 0 Td
(how-)Tj
-34.2252 -1.3039 Td
(ever,)Tj
2.1146 0 Td
(this)Tj
1.6781 0 Td
(result)Tj
2.4491 0 Td
(is)Tj
0.8447 0 Td
(not)Tj
1.5761 0 Td
(consistent)Tj
4.2576 0 Td
(across)Tj
2.6759 0 Td
(all)Tj
1.1452 0 Td
(studies)Tj
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(22)Tj
0 g
(].)Tj
-20.2676 -1.2982 Td
(In)Tj
1.1111 0 Td
(earlier)Tj
2.7553 0 Td
(work)Tj
2.279 0 Td
(we)Tj
1.3266 0 Td
(have)Tj
2.0637 0 Td
(shown,)Tj
3.0727 0 Td
(using)Tj
2.3867 0 Td
(an)Tj
1.2076 0 Td
(experimental)Tj
5.4538 0 Td
(model)Tj
2.7439 0 Td
(for)Tj
/F11 1 Tf
1.389 0 Td
[()136()]TJ
0.9921 0 Td
[( )6()2(\n)-9()10()-8(\r)12()6()7()-3( )]TJ
/F6 1 Tf
4.4787 0 Td
(burn)Tj
2.1714 0 Td
(wound)Tj
-34.6278 -1.2983 Td
(infections)Tj
4.1498 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(rat,)Tj
1.5477 0 Td
(that)Tj
1.7801 0 Td
(treatment)Tj
4.1386 0 Td
(with)Tj
1.9955 0 Td
(inhibitors)Tj
4.1386 0 Td
(can)Tj
1.6271 0 Td
(significantly)Tj
5.091 0 Td
(reduce)Tj
2.9196 0 Td
(the)Tj
1.4684 0 Td
(bacterial)Tj
3.6226 0 Td
(bur-)Tj
-34.9849 -1.3039 Td
(den)Tj
1.7177 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(wound)Tj
3.0161 0 Td
(without)Tj
3.3278 0 Td
(impeding)Tj
4.0592 0 Td
(wound)Tj
3.0161 0 Td
(closure)Tj
3.0784 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(])Tj
1.8538 0 Td
(\(see)Tj
1.7632 0 Td
(Experimental)Tj
5.6069 0 Td
(set-up)Tj
2.6985 0 Td
(for)Tj
1.3833 0 Td
(more)Tj
-34.0268 -1.2983 Td
(details\).)Tj
/F11 1 Tf
3.3391 0 Td
[()39()]TJ
1.0829 0 Td
[()-13(\r)14()7(\n)20()]TJ
/F6 1 Tf
2.0409 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.0579 0 Td
(also)Tj
1.7688 0 Td
(demonstrated)Tj
5.76 0 Td
(the)Tj
1.474 0 Td
(efficacy)Tj
3.2202 0 Td
(of)Tj
1.0148 0 Td
(inhibitor)Tj
3.7813 0 Td
(treatment)Tj
4.1329 0 Td
(in)Tj
1.0375 0 Td
(reducing)Tj
-33.698 -1.2983 Td
(cytotoxicity)Tj
4.8812 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2642 0 Td
(24)Tj
0 g
(])Tj
1.508 0 Td
(and)Tj
1.7348 0 Td
(have)Tj
2.058 0 Td
(shown)Tj
2.8459 0 Td
(that)Tj
1.7802 0 Td
(inhibitors)Tj
4.1442 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.5761 0 Td
(interfere)Tj
3.634 0 Td
(with)Tj
1.9955 0 Td
(host)Tj
1.9163 0 Td
(cell)Tj
1.559 0 Td
(functions)Tj
-32.1503 -1.2982 Td
(critical)Tj
2.948 0 Td
(to)Tj
1.0261 0 Td
(wound)Tj
3.016 0 Td
(healing)Tj
3.1351 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
-8.929 -1.3039 Td
(A)Tj
0.907 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(mathematical)Tj
5.6466 0 Td
(modelling)Tj
4.2689 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.058 0 Td
(considered)Tj
4.6034 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(anti-virulence)Tj
-30.115 -1.2983 Td
(treatments)Tj
4.4957 0 Td
(to)Tj
1.0261 0 Td
(combat)Tj
3.2088 0 Td
(bacterial)Tj
3.6227 0 Td
(infections.)Tj
4.3766 0 Td
(The)Tj
1.7858 0 Td
(majority)Tj
3.6284 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2563 0 Td
(studies)Tj
2.9821 0 Td
(focus)Tj
2.33 0 Td
(upon)Tj
2.3187 0 Td
(anti-quo-)Tj
-33.046 -1.2983 Td
(rum)Tj
1.9388 0 Td
(sensing)Tj
3.1918 0 Td
(treatments)Tj
4.4957 0 Td
(\(see,)Tj
1.9956 0 Td
(for)Tj
1.389 0 Td
(example,)Tj
3.77 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(]\).)Tj
3.8892 0 Td
(An)Tj
1.4513 0 Td
(exception)Tj
4.0932 0 Td
(to)Tj
1.0261 0 Td
(this)Tj
1.6725 0 Td
(rule;)Tj
2.0182 0 Td
(the)Tj
1.4683 0 Td
(model)Tj
2.744 0 Td
(in)Tj
-35.1437 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(])Tj
1.8481 0 Td
(is)Tj
0.8504 0 Td
(of)Tj
1.0148 0 Td
(particular)Tj
4.1102 0 Td
(relevance)Tj
3.9685 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(present)Tj
3.1634 0 Td
(work.)Tj
2.5058 0 Td
(This)Tj
1.9843 0 Td
(ordinary)Tj
3.702 0 Td
(differential)Tj
4.6034 0 Td
(equation)Tj
3.7361 0 Td
(\(ODE\))Tj
-33.9815 -1.2982 Td
(model)Tj
2.7439 0 Td
(considers)Tj
4.0081 0 Td
(a)Tj
0.6577 0 Td
(general)Tj
3.1294 0 Td
(anti-virulence)Tj
5.8053 0 Td
(treatment,)Tj
4.3597 0 Td
(which)Tj
2.6532 0 Td
(operates)Tj
3.5546 0 Td
(by)Tj
1.1792 0 Td
(enhancing)Tj
4.4107 0 Td
(innate)Tj
-32.5018 -1.2983 Td
(immunity)Tj
4.2235 0 Td
(in)Tj
1.0318 0 Td
(bacterial)Tj
3.6284 0 Td
(clearance.)Tj
4.1725 0 Td
(The)Tj
1.7802 0 Td
(model)Tj
2.7439 0 Td
(predicts)Tj
3.4129 0 Td
(that,)Tj
2.0013 0 Td
(when)Tj
2.4037 0 Td
(used)Tj
2.0636 0 Td
(in)Tj
1.0318 0 Td
(isolation,)Tj
3.8835 0 Td
(anti-viru-)Tj
-32.3771 -1.3039 Td
(lence)Tj
2.2847 0 Td
(treatment)Tj
4.1328 0 Td
(is)Tj
0.8504 0 Td
(unlikely)Tj
3.4299 0 Td
(to)Tj
1.0262 0 Td
(eliminate)Tj
3.9458 0 Td
(a)Tj
0.6576 0 Td
(bacterial)Tj
3.6227 0 Td
(infection.)Tj
4.0195 0 Td
(However,)Tj
4.0762 0 Td
(the)Tj
1.4683 0 Td
(model)Tj
2.7439 0 Td
(predicts)Tj
3.4072 0 Td
(that,)Tj
-35.6652 -1.2983 Td
(when)Tj
2.4037 0 Td
(combined)Tj
4.2406 0 Td
(with)Tj
2.0013 0 Td
(antibiotics,)Tj
4.6204 0 Td
(anti-virulence)Tj
5.8053 0 Td
(treatments)Tj
4.4957 0 Td
(could)Tj
2.4548 0 Td
(eliminate)Tj
3.9458 0 Td
(bacteria,)Tj
3.6057 0 Td
(provided)Tj
-33.5733 -1.2983 Td
(antibiotic)Tj
4.0365 0 Td
(and)Tj
1.7291 0 Td
(anti-virulence)Tj
5.8053 0 Td
(treatments)Tj
4.4957 0 Td
(are)Tj
1.4513 0 Td
(applied)Tj
3.1522 0 Td
(in)Tj
1.0374 0 Td
(staggered)Tj
3.9855 0 Td
(doses.)Tj
2.6306 0 Td
(Other)Tj
2.5851 0 Td
(modelling)Tj
4.269 0 Td
(work)Tj
-35.1777 -1.3039 Td
(has)Tj
1.542 0 Td
(considered)Tj
4.5978 0 Td
(the)Tj
1.474 0 Td
(bacterial)Tj
3.6226 0 Td
(invasion)Tj
3.6057 0 Td
(of)Tj
1.0148 0 Td
(burn)Tj
2.177 0 Td
(wounds)Tj
3.3788 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.4683 0 Td
(resultant)Tj
3.7304 0 Td
(tissue)Tj
2.4547 0 Td
(damage)Tj
3.3279 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(35)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
-35.858 -1.2982 Td
(37)Tj
0 g
(],)Tj
1.7347 0 Td
(the)Tj
1.4684 0 Td
(influence)Tj
3.9174 0 Td
(of)Tj
1.0148 0 Td
(bacterial)Tj
3.6284 0 Td
(infection)Tj
3.787 0 Td
(upon)Tj
2.3244 0 Td
(the)Tj
1.4684 0 Td
(healing)Tj
3.1294 0 Td
(of)Tj
1.0148 0 Td
(burn)Tj
2.177 0 Td
(wounds)Tj
3.3788 0 Td
([)Tj
0.83 0.64 0.02 0 k
(38)Tj
0 g
(])Tj
1.8482 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4741 0 Td
(effects)Tj
-34.0949 -1.2983 Td
(of)Tj
1.0147 0 Td
(ambient)Tj
3.515 0 Td
(gas)Tj
1.4797 0 Td
(plasma)Tj
3.033 0 Td
(treatment)Tj
4.1386 0 Td
(in)Tj
1.0318 0 Td
(this)Tj
1.6781 0 Td
(context)Tj
3.1804 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(].)Tj
2.0806 0 Td
(Each)Tj
2.1714 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2563 0 Td
(models)Tj
3.1068 0 Td
(is)Tj
0.8447 0 Td
(formulated)Tj
4.6658 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
-36.2265 -1.2983 Td
(system)Tj
2.9366 0 Td
(of)Tj
1.0148 0 Td
(partial)Tj
2.7893 0 Td
(differential)Tj
4.6034 0 Td
(equations)Tj
4.0932 0 Td
(in)Tj
1.0375 0 Td
(one)Tj
1.6951 0 Td
(or)Tj
1.0998 0 Td
(two)Tj
1.7122 0 Td
(spatial)Tj
2.7779 0 Td
(dimensions.)Tj
5.074 0 Td
(Models)Tj
3.1804 0 Td
(have)Tj
2.058 0 Td
(also)Tj
-34.0722 -1.3039 Td
(been)Tj
2.1203 0 Td
(developed)Tj
4.2746 0 Td
(to)Tj
1.0204 0 Td
(describe)Tj
3.5263 0 Td
(microbial)Tj
4.0649 0 Td
(adhesion)Tj
3.8154 0 Td
(to)Tj
1.0261 0 Td
(surfaces,)Tj
3.634 0 Td
(for)Tj
1.3833 0 Td
(example,)Tj
3.7757 0 Td
([)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(])Tj
1.8539 0 Td
(developed)Tj
4.2689 0 Td
(an)Tj
-34.7638 -1.2983 Td
(ODE)Tj
2.2733 0 Td
(model)Tj
2.7439 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(competitive)Tj
4.9209 0 Td
(colonisation)Tj
5.1363 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(gut)Tj
1.5137 0 Td
(wall)Tj
1.8311 0 Td
(by)Tj
1.1792 0 Td
(host)Tj
1.9162 0 Td
(and)Tj
1.7292 0 Td
(invader)Tj
3.2485 0 Td
(strains)Tj
2.8573 0 Td
(of)Tj
/F11 1 Tf
-34.6845 -1.2982 Td
[()-4()-3()13()6()2(\n)-9(\r)4()13()18(\r)4( )]TJ
4.6261 0 Td
[()7()10()12(\r)]TJ
/F6 1 Tf
(.)Tj
1.7858 0 Td
(Lastly,)Tj
2.7779 0 Td
([)Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(])Tj
1.8482 0 Td
(have)Tj
2.0636 0 Td
(developed)Tj
4.2689 0 Td
(an)Tj
1.2019 0 Td
(individual-based)Tj
6.8938 0 Td
(model)Tj
2.744 0 Td
(to)Tj
1.0261 0 Td
(describe)Tj
3.5263 0 Td
(the)Tj
1.4683 0 Td
(coloni-)Tj
-34.2309 -1.3039 Td
(sation)Tj
2.6362 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(generic)Tj
3.1408 0 Td
(surface)Tj
3.05 0 Td
(by)Tj
1.1849 0 Td
(phenotypically)Tj
6.0831 0 Td
(heterogeneous)Tj
6.0264 0 Td
(bacteria,)Tj
3.6057 0 Td
(in)Tj
1.0375 0 Td
(which)Tj
2.6475 0 Td
(bacteria)Tj
3.3789 0 Td
(may)Tj
-34.4577 -1.2983 Td
(migrate)Tj
3.2995 0 Td
(between)Tj
3.5262 0 Td
(the)Tj
1.4684 0 Td
(surface)Tj
3.05 0 Td
(and)Tj
1.7292 0 Td
(a)Tj
0.6576 0 Td
(liquid)Tj
2.5625 0 Td
(medium.)Tj
-15.0972 -1.2983 Td
(In)Tj
1.1111 0 Td
(this)Tj
1.6725 0 Td
(paper,)Tj
2.7099 0 Td
(we)Tj
1.3266 0 Td
(construct)Tj
3.9798 0 Td
(a)Tj
0.6576 0 Td
(mathematical)Tj
5.6409 0 Td
(model,)Tj
2.9707 0 Td
(formulated)Tj
4.6658 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(system)Tj
2.9367 0 Td
(of)Tj
1.0148 0 Td
(ODEs,)Tj
2.8629 0 Td
(to)Tj
-34.4123 -1.3039 Td
(describe)Tj
3.5206 0 Td
(the)Tj
1.474 0 Td
(population)Tj
4.5864 0 Td
(dynamics)Tj
4.0592 0 Td
(and)Tj
1.7291 0 Td
(treatment)Tj
4.1386 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(bacterial)Tj
3.6227 0 Td
(infection)Tj
3.7927 0 Td
(within)Tj
2.812 0 Td
(a)Tj
0.6576 0 Td
(burn)Tj
2.1713 0 Td
(wound.)Tj
-34.2309 -1.2982 Td
(Basing)Tj
2.8743 0 Td
(our)Tj
1.627 0 Td
(mathematical)Tj
5.6466 0 Td
(model)Tj
2.7439 0 Td
(upon)Tj
2.3188 0 Td
(Huebinger)Tj
/F11 1 Tf
4.524 0 Td
[()8()]TJ
0.9071 0 Td
[( )11()]TJ
/F6 1 Tf
(.'s)Tj
1.7461 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(])Tj
1.8482 0 Td
(experiments,)Tj
5.3631 0 Td
(we)Tj
1.3323 0 Td
(use)Tj
1.5307 0 Td
(it)Tj
0.7824 0 Td
(to)Tj
1.0261 0 Td
(explain)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 169.285 23.6976 re
W* n
q
169.2283 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 394.4125 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Predictiv)Tj
3.763 0 Td
(e)Tj
0.7653 0 Td
(modelling)Tj
4.415 0 Td
(of)Tj
1.0418 0 Td
(a)Tj
0.7653 0 Td
(novel)Tj
2.5583 0 Td
(anti-adhesion)Tj
6.1087 0 Td
(therapy)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
142.5827 34.9228 m
295.8236 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Computationa)Tj
6.1229 0 Td
(l)Tj
0.4322 0 Td
(Biology)Tj
3.4371 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https:/)Tj
2.6788 0 Td
(/doi.org/10.13)Tj
6.0094 0 Td
(71/journal.p)Tj
5.1166 0 Td
(cbi.1006071)Tj
0 g
6.3497 0 Td
(May)Tj
2.0835 0 Td
(3,)Tj
1.0417 0 Td
(2018)Tj
28.538 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
80 0 obj
<>stream
endstream
endobj
81 0 obj
<>stream
endstream
endobj
82 0 obj
<>stream
endstream
endobj
83 0 obj
<>stream
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
endstream
endobj
89 0 obj
<>stream
endstream
endobj
90 0 obj
<>stream
endstream
endobj
91 0 obj
<>stream
endstream
endobj
92 0 obj
<>stream
endstream
endobj
93 0 obj
<>stream
endstream
endobj
94 0 obj
<>stream
endstream
endobj
95 0 obj
<>stream
endstream
endobj
96 0 obj
<>stream
endstream
endobj
97 0 obj
<>stream
endstream
endobj
98 0 obj
<>stream
endstream
endobj
99 0 obj
<>stream
endstream
endobj
100 0 obj
<>stream
endstream
endobj
101 0 obj
<>stream
endstream
endobj
102 0 obj
<>stream
BT
66.402 0 Td
(28)Tj
ET
Q
endstream
endobj
103 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 107 0 R/Contents 108 0 R/TrimBox[0 0 612 792]>>
endobj
106 0 obj
<>stream
xwfE>&*@
JP@Q0 Q` H
HRPŌ`BDV蠨bv
~|3L̩?=uUSUFhFhFhFhFhFhFhFhFhFhFhFhFhFhFhFhFhFhFhFhFhF`a _+?r??ratlӧQiBZ'N%i˄Y;4@#4@#4@#4w-ýF@JH&!l+uiZbv4s<{J[FhFhFhF(__CP]3?믟vE *N?E]tW;;묳jM"nFhFhFhC-Zz/{u{̈́pmWvD3|nVƍe~{_|W 4f]3FhFhFhF]>FP7Zj)lWe]j]Y/~Qۿ\gE~8y˗OpD#4@#4@#4@#!ӟDxV+Bˈ+xM7f,w~k` i핳߯}U]E#4@#4@#4@#,pAAhiK% S=FB??ZSkf\7x^
=]!a1i 'i'3~6hFhFhFp:L˓d^BBZfK|%`3oXj`_W/KZ`@nlFhFhFhE@xH$7_~yvAV`c:"!Zk\^?aKsqY2rˡnNG3K5@#4@#4@#4|2#K?x ,P
ez]veШw߽Xj/IC@IZ
mfH4@#4@#4@#4w)^|toXV*~;]eB 1_~O}Swwr-78eϜ1B[磌"^xA,l͍@#4@#4@#4@#X"UvI7&N sOlLq2AS4FmKEnH{c-ܲkhc13i)N&wUKeC$g~FhFhFhF!ƠVB/z,&K039τpiӄYH0[{
tGa00ifP47xchVY4K!_4@#4@#4@#,c;8tDx "?#Gꫯo[YHpw_sAh,)QC@-Rx?RN 4@#4@#4@#4#Q0YcXR"TL"acrvۥ"_LpN/9fmN4&C#2zֳ҄ljLk]4@#4@#4@#43!'a@\q!29.C83c(tD?4c8aF%# VQRb&jUW;A &3FhFhFhF@H[bC=ؐ0YgK/T)aPomؤuQiXa(N4`,]"lBJ1ÆfXSɥͻw֒`Gp( I'4&M?A:34O&LXY|s^zI[]xN=TQ2=T#H
J3IXC/_ɋZ2]P)>P+?|jaNΒIZAk?זR2.ٟ&YFhFhFs؞N O~-ܲȇmXp%0N>̱%/yIh%ӉF`#
sr&<̷zG<}V?Yaqn$]ƗfDl!_1}6x)kҦ-dFhFhF'49߸};Fd^WT&,V1335yXKF_yc_ZU2;<{{]t2,͑gwbU~jŽgzoUtѰګύ}krK # $Xda/9?&h[ )#C#4@#4@#421zo~zS$-\e2ai{p{[mq\y
0PT2E/+~7}qJYy?^u]#{g?{qǽ]B(6([@6E#<)OyJwQKR"B%gu/G<q5ݒ`sG+o@#4@#4@qP_xEsc$8k:3Mj+;ѶJc|9\|.8t'i|Kzkܵ4w<7t+_<}|)wȿL-N6@#4@#4M&5>'7pCnn?n&4\U2IKaznpiZHfrVhIö-1_8ș[jn;ɬDxr2O|GK2-{Yo<ޞjU^VzIIɯM̑/}G^@$%\Poxl|iBS[NY>~{+˦vml N2o%j405_?4kbUT w#Mpwݘ+@1z:4@#4@#43cxx3|$C;UW]/*|̚;aE3?My 1_bK@o-x<3y`x8xI )r l%{,J-")!M7ԛg?;C!g,K&3m3-uSR>IB"P
iiR#Z$XL'$0'4Em@A2-LA Isy){sW?co!K(
z$mLET
HlW]uU/$h.p?a`iD#4@#4@#"/2g2ߙ:>ꨣ"?lˑT涍C/2?2U1=;@ħ>x~8(
"y(v}MjQ/Jd=ghd&V{N1o&MMyV7kfN25wW1z
eT
KiE$B{L<ɑOW63g=!oe*
/U$GJ%Z6Q_43@p+ݐByxtA)E;ḭ-eݒ{)2"=Ηdjtѩq
63g|DF
jBUT?3RiIrDr>AoU
0S#Riy$RhFhFhق@&;dd]v1LJd?i$hP
eBdrI怾}7̿|~$kS2]"LAvVfm/RQ،FԈm^~D1CK 3/~3%Fޔ;l*2&YJ{Zq'!h&$<|ܥ02imTKRS&=Z9g
HrXK$Fw9b3X2;4@#4@#4C8#}{J