%PDF-1.3
%
1 0 obj
<<
/Names 2 0 R
/Type /Catalog
/Outlines 3 0 R
/OutputIntents [4 0 R 5 0 R]
/Metadata 6 0 R
/PageMode /UseOutlines
/Pages 7 0 R
>>
endobj
8 0 obj
<<
/Producer <4163726F6261742044697374696C6C65722031302E312E35202857696E646F7773293B206D6F646966696564207573696E67206954657874AE20352E332E3520A9323030302D32303132203154335854204256424120284147504C2D76657273696F6E29>
/CrossmarkMajorVersionDate (2016-08-15)
/Keywords (Intra-cluster correlation coefficient,Inter-period correlation coefficient,Cluster randomised trial,Type-2 diabetes)
/CrossMarkDomains#5B1#5D (springer.com)
/ModDate (D:20160815052022+02'00')
/Subject (Trials, 2016, doi:10.1186/s13063-016-1532-9)
/Creator (Arbortext Advanced Print Publisher 9.1.440/W Unicode)
/Title (Intra-cluster and inter-period correlation coefficients for cross-sectional cluster randomised controlled trials for type-2 diabetes in UK primary care)
/CrossMarkDomains#5B2#5D (springerlink.com)
/doi (10.1186/s13063-016-1532-9)
/CrossmarkDomainExclusive (true)
/Author (James Martin)
/CreationDate (D:20160815074908+08'00')
>>
endobj
2 0 obj
<<
/Dests 9 0 R
>>
endobj
3 0 obj
<<
/Type /Outlines
/Count 32
/Last 10 0 R
/First 11 0 R
>>
endobj
4 0 obj
<<
/Type /OutputIntent
/OutputCondition (sRGB)
/DestOutputProfile 12 0 R
/S /GTS_PDFA1
/OutputConditionIdentifier (Custom)
/RegistryName ()
/Info (sRGB IEC61966-2.1)
>>
endobj
5 0 obj
<<
/Type /OutputIntent
/OutputCondition (sRGB)
/DestOutputProfile 12 0 R
/S /ISO_PDFE1
/OutputConditionIdentifier (Custom)
/RegistryName ()
/Info (sRGB IEC61966-2.1)
>>
endobj
6 0 obj
<<
/Length 32010
/Type /Metadata
/Subtype /XML
>>
stream
10.1186/s13063-016-1532-9
2016-08-15
true
springer.com
springerlink.com
VoR
Intra-cluster correlation coefficient,Inter-period correlation coefficient,Cluster randomised trial,Type-2 diabetes
Acrobat Distiller 10.1.5 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
2016-08-15
true
10.1186/s13063-016-1532-9
springer.com
springerlink.com
http://dx.doi.org/10.1186/s13063-016-1532-9
10.1186/s13063-016-1532-9
1745-6215
journal
Trials
Martin et al.
application/pdf
10.1186/s13063-016-1532-9
Trials
Trials, 2016, doi:10.1186/s13063-016-1532-9
Intra-cluster correlation coefficient
Inter-period correlation coefficient
Cluster randomised trial
Type-2 diabetes
Intra-cluster and inter-period correlation coefficients for cross-sectional cluster randomised controlled trials for type-2 diabetes in UK primary care
James Martin
Alan Girling
Krishnarajah Nirantharakumar
Ronan Ryan
Tom Marshall
Karla Hemming
2016-08-15T05:20:22+02:00
2016-08-15T05:20:22+02:00
2016-08-15T07:49:08+08:00
Arbortext Advanced Print Publisher 9.1.440/W Unicode
uuid:c08fc189-a0ab-4c73-a4b0-4ec98e0dd238
uuid:1251ca40-2e13-4b33-b5c0-ecc3917d41fa
default
1
converted
uuid:c08fc189-a0ab-4c73-a4b0-4ec98e0dd238
converted to PDF/A-2b
pdfToolbox
2016-08-15T07:52:57+08:00
2
B
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
internal
A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.
DerivedFrom
ResourceRef
Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.
http://ns.adobe.com/xap/1.0/sType/Part#
stPart
Part
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
Springer ORCiD Schema
http://springer.com/ns/xmpExtensions/1.0/
springer
authorInfo
AuthorInformation
external
Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
AuthorInformation
http://springer.com/ns/xmpExtensions/1.0/authorinfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
http://ns.adobe.com/pdfx/1.3/
pdfx
PDF/X ID Schema
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
Seq Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
internal
Mirrors crossmark:DOI
doi
Text
http://crossref.org/crossmark/1.0/
crossmark
crossmark
internal
CrossMarkDomains
CrossMarkDomains
Seq Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was published.
MajorVersionDate
Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism
external
The aggregation type specifies the unit of aggregation for a content collection.
Comment
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element.
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Copyrigh
copyright
Text
external
The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only.
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs.
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn.
issn
Text
external
Title of the magazine, or other publication, in which a resource was/will be published.
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date.
Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
This element provides the url for an article or unit of content.
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element.
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
Text
http://ns.adobe.com/xap/1.0/t/pg/
xmpTPg
XMP Paged-Text
internal
A structure containing the characteristics of a font used in a document
Fonts
Bag Font
internal
XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).
PlateNames
Seq Text
A structure containing the characteristics of a font used in a document.
http://ns.adobe.com/xap/1.0/sType/Font#
stFnt
Font
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
7 0 obj
<<
/ITXT (5.1.0)
/Type /Pages
/Count 13
/Kids [13 0 R 14 0 R]
>>
endobj
9 0 obj
<<
/Kids [15 0 R 16 0 R 17 0 R]
>>
endobj
10 0 obj
<<
/C [0 0 0]
/Parent 3 0 R
/F 0
/Title
/Dest
/Prev 18 0 R
/Count 0
>>
endobj
11 0 obj
<<
/Next 19 0 R
/C [0 0 0]
/Parent 3 0 R
/F 0
/Title
/Dest
/Count 4
/Last 20 0 R
/First 21 0 R
>>
endobj
12 0 obj
<<
/Length 2574
/N 3
/Filter /FlateDecode
/Range [0 1 0 1 0 1]
>>
stream
HyTSwoɞc
[5laQIBHADED2mtFOE.c}088GNg9w߽ '0 ֠Jb
2y.-;!KZ ^i"L0-
@8(r;q7Ly&Qq4j|9
V)gB0iW8#8wթ8_٥ʨQQj@&A)/g>'K t;\
ӥ$պFZUn(4T%)뫔0C&Zi8bxEB;Pӓ̹Aom?W=
x- [ 0}y)7ta>jT7@tܛ`q2ʀ&6ZLĄ?_yxg)˔zçLU*uSkSeO4?c. R
߁-25 S>ӣVd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L`< "AYA+Cb(R, *T2B-
ꇆnQt}MA0alSx k&^>0|>_',G!"F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VĭKĻYdE"EI2EBGt4MzNr!YK ?%_(0J:EAiQ(()ӔWT6U@P+!~mDeԴ!hӦh/']B/ҏӿ?a0nhF!X8܌kc&5S6lIa2cKMA!E#ƒdV(kel
}}Cq9
N')].uJr
wG xR^[oƜchg`>b$*~ :Eb~,m,-ݖ,Y¬*6X[ݱF=3뭷Y~dó tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:˜O:ϸ8uJqnv=MmR 4
n3ܣkGݯz=[==<=GTB(/S,]6*-W:#7*e^YDY}UjAyT`#D="b{ų+ʯ:!kJ4Gmt}uC%K7YVfFY.=b?SƕƩȺy
چk5%4m7lqlioZlG+Zzmzy]?uuw|"űNwW&e֥ﺱ*|j5kyݭǯg^ykEklD_p߶7Dmo꿻1ml{Mś
nLl<9O [$h՛BdҞ@iءG&vVǥ8nRĩ7u\ЭD- u`ֲK³8%yhYѹJº;.!
zpg_XQKFAǿ=ȼ:ɹ8ʷ6˶5̵5͵6ζ7ϸ9к<Ѿ?DINU\dlvۀ܊ݖޢ)߯6DScs
2F[p(@Xr4Pm8Ww)Km
endstream
endobj
13 0 obj
<<
/Parent 7 0 R
/Type /Pages
/Count 11
/Kids [22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R
32 0 R]
>>
endobj
14 0 obj
<<
/Parent 7 0 R
/Type /Pages
/Count 2
/Kids [33 0 R 34 0 R]
>>
endobj
15 0 obj
<<
/Names [ 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R
40 0 R 41 0 R 42 0 R 43 0 R 44 0 R
45 0 R 46 0 R 47 0 R 48 0 R 49 0 R
50 0 R 51 0 R 52 0 R 53 0 R 54 0 R
55 0 R 56 0 R 57 0 R 58 0 R 59 0 R
60 0 R 61 0 R 62 0 R 63 0 R 64 0 R
65 0 R 66 0 R 67 0 R 68 0 R 69 0 R
70 0 R 71 0 R 72 0 R 73 0 R 74 0 R
75 0 R 76 0 R 77 0 R 78 0 R 79 0 R
80 0 R 81 0 R 82 0 R 83 0 R 84 0 R
85 0 R 86 0 R 87 0 R 88 0 R 89 0 R
90 0 R 91 0 R 92 0 R 93 0 R 94 0 R
95 0 R 96 0 R 97 0 R 98 0 R]
/Limits [ ]
>>
endobj
16 0 obj
<<
/Names [ 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R
104 0 R 105 0 R 106 0 R 107 0 R 108 0 R
109 0 R 110 0 R 111 0 R 112 0 R 113 0 R
114 0 R 115 0 R 116 0 R 117 0 R 118 0 R
119 0 R 120 0 R 121 0 R 122 0 R 123 0 R
124 0 R 125 0 R 126 0 R 127 0 R 128 0 R
129 0 R 130 0 R 131 0 R 132 0 R 133 0 R
134 0 R 135 0 R 136 0 R 137 0 R 138 0 R
139 0 R 140 0 R 141 0 R 142 0 R 143 0 R
144 0 R 145 0 R 146 0 R 147 0 R 148 0 R
149 0 R 150 0 R 151 0 R 152 0 R 153 0 R
154 0 R 155 0 R 156 0 R 157 0 R 158 0 R
159 0 R 160 0 R 161 0 R 162 0 R]
/Limits [ ]
>>
endobj
17 0 obj
<<
/Names [ 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R
168 0 R 169 0 R 170 0 R 171 0 R 172 0 R
173 0 R 174 0 R 175 0 R 176 0 R]
/Limits [ ]
>>
endobj
18 0 obj
<<
/Next 10 0 R
/C [0 0 0]
/Parent 3 0 R
/F 0
/Title
/Dest
/Prev 177 0 R
/Count 0
>>
endobj
19 0 obj
<<
/Next 178 0 R
/C [0 0 0]
/Parent 3 0 R
/F 0
/Title
/Dest
/Prev 11 0 R
/Count 0
>>
endobj
20 0 obj
<<
/C [0 0 0]
/Parent 11 0 R
/F 0
/Title
/Dest
/Prev 179 0 R
/Count 0
>>
endobj
21 0 obj
<<
/Next 180 0 R
/C [0 0 0]
/Parent 11 0 R
/F 0
/Title
/Dest
/Count 0
>>
endobj
22 0 obj
<<
/Contents 181 0 R
/Type /Page
/Resources <<
/Font <<
/F1 182 0 R
/F2 183 0 R
/F3 184 0 R
/F4 185 0 R
>>
/XObject <<
/Xf1 186 0 R
>>
>>
/Annots [187 0 R 188 0 R 189 0 R]
/Parent 13 0 R
/MediaBox [0 0 595 842]
>>
endobj
23 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents [190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R]
/Resources <<
/ExtGState <<
/GS17 198 0 R
/GS19 199 0 R
/GS15 200 0 R
/GS7 201 0 R
/GS13 202 0 R
/GS9 203 0 R
/GS11 204 0 R
>>
/XObject <<
/X1 205 0 R
/Im1 206 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageI /ImageB]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 208 0 R
/F2 209 0 R
/F3 210 0 R
/F4 211 0 R
/F5 212 0 R
/F6 213 0 R
/F8 214 0 R
>>
/Properties <<
/MC1 215 0 R
/MC2 216 0 R
/MC3 217 0 R
/MC4 218 0 R
>>
>>
/Thumb 219 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [220 0 R 221 0 R 222 0 R 223 0 R]
/Rotate 0
>>
endobj
24 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents 224 0 R
/Resources <<
/ExtGState <<
/GS8 203 0 R
/GS4 225 0 R
/GS6 204 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 208 0 R
/F2 209 0 R
/F3 214 0 R
/F10 226 0 R
/F4 211 0 R
/F11 227 0 R
/F6 213 0 R
/F14 228 0 R
/F9 229 0 R
/F8 230 0 R
/F12 231 0 R
/F13 232 0 R
>>
>>
/Thumb 233 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [234 0 R 235 0 R 236 0 R 237 0 R 238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R
244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R 250 0 R 251 0 R 252 0 R 253 0 R
254 0 R 255 0 R 256 0 R 257 0 R 258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R
264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R]
/Rotate 0
>>
endobj
25 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents 274 0 R
/Resources <<
/ExtGState <<
/GS8 203 0 R
/GS4 225 0 R
/GS6 204 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 214 0 R
/F2 209 0 R
/F10 226 0 R
/F4 211 0 R
/F11 227 0 R
/F6 213 0 R
/F14 228 0 R
/F9 229 0 R
/F8 230 0 R
/F12 231 0 R
/F13 232 0 R
>>
>>
/Thumb 275 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [276 0 R 277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R]
/Rotate 0
>>
endobj
26 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents 283 0 R
/Resources <<
/ExtGState <<
/GS4 225 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 214 0 R
/F2 209 0 R
/F4 211 0 R
/F6 213 0 R
/F9 229 0 R
/F8 230 0 R
>>
>>
/Thumb 284 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [285 0 R 286 0 R 287 0 R 288 0 R 289 0 R 290 0 R 291 0 R]
/Rotate 0
>>
endobj
27 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents 292 0 R
/Resources <<
/ExtGState <<
/GS4 225 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 208 0 R
/F2 209 0 R
/F3 214 0 R
/F4 211 0 R
/F6 213 0 R
/F9 229 0 R
/F8 230 0 R
>>
>>
/Thumb 293 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R 301 0 R 302 0 R]
/Rotate 0
>>
endobj
28 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents 303 0 R
/Resources <<
/ExtGState <<
/GS8 203 0 R
/GS4 225 0 R
/GS6 204 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 208 0 R
/F2 209 0 R
/F3 210 0 R
/F4 211 0 R
/F11 214 0 R
/F5 212 0 R
/F6 213 0 R
/F9 229 0 R
/F15 304 0 R
/F8 230 0 R
>>
>>
/Thumb 305 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [306 0 R 307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R
316 0 R 317 0 R 318 0 R 319 0 R 320 0 R 321 0 R 322 0 R 323 0 R 324 0 R 325 0 R
326 0 R 327 0 R 328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R 334 0 R 335 0 R
336 0 R]
/Rotate 0
>>
endobj
29 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents 337 0 R
/Resources <<
/ExtGState <<
/GS8 203 0 R
/GS4 225 0 R
/GS6 204 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 208 0 R
/F2 209 0 R
/F3 210 0 R
/F4 211 0 R
/F11 214 0 R
/F5 212 0 R
/F6 213 0 R
/F9 229 0 R
/F15 304 0 R
/F8 230 0 R
>>
>>
/Thumb 338 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R 346 0 R]
/Rotate 0
>>
endobj
30 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents 347 0 R
/Resources <<
/ExtGState <<
/GS8 204 0 R
/GS4 225 0 R
/GS10 203 0 R
/GS6 348 0 R
>>
/XObject <<
/Im3 349 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageB /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 208 0 R
/F2 209 0 R
/F3 210 0 R
/F10 214 0 R
/F4 211 0 R
/F6 213 0 R
/F9 229 0 R
/F15 304 0 R
/F8 230 0 R
>>
>>
/Thumb 350 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [351 0 R 352 0 R 353 0 R 354 0 R 355 0 R 356 0 R 357 0 R 358 0 R 359 0 R 360 0 R
361 0 R 362 0 R 363 0 R 364 0 R 365 0 R 366 0 R]
/Rotate 0
>>
endobj
31 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents 367 0 R
/Resources <<
/ExtGState <<
/GS8 203 0 R
/GS4 225 0 R
/GS6 204 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 208 0 R
/F2 209 0 R
/F3 210 0 R
/F6 213 0 R
/F8 214 0 R
>>
>>
/Thumb 368 0 R
/MediaBox [0 0 595.276 790.866]
/Rotate 0
>>
endobj
32 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 13 0 R
/Type /Page
/Contents 369 0 R
/Resources <<
/ExtGState <<
/GS8 203 0 R
/GS4 225 0 R
/GS6 204 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 208 0 R
/F2 209 0 R
/F3 210 0 R
/F4 211 0 R
/F11 214 0 R
/F5 212 0 R
/F6 213 0 R
/F8 230 0 R
/F13 232 0 R
/F16 370 0 R
>>
>>
/Thumb 371 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R
382 0 R 383 0 R 384 0 R 385 0 R 386 0 R 387 0 R 388 0 R 389 0 R 390 0 R 391 0 R]
/Rotate 0
>>
endobj
33 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 14 0 R
/Type /Page
/Contents 392 0 R
/Resources <<
/ExtGState <<
/GS4 225 0 R
/GS6 204 0 R
>>
/XObject <<
/Im4 393 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 208 0 R
/F2 209 0 R
/F3 210 0 R
/F10 214 0 R
/F4 211 0 R
/F5 212 0 R
/F6 213 0 R
/F8 230 0 R
/F17 394 0 R
>>
/Properties <<
/MC5 395 0 R
>>
>>
/Thumb 396 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [397 0 R 398 0 R 399 0 R 400 0 R 401 0 R 402 0 R 403 0 R 404 0 R 405 0 R 406 0 R]
/Rotate 0
>>
endobj
34 0 obj
<<
/CropBox [0 0 595.276 790.866]
/Parent 14 0 R
/Type /Page
/Contents 407 0 R
/Resources <<
/ExtGState <<
/GS4 225 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ColorSpace <<
/DefaultCMYK [/ICCBased 207 0 R]
>>
/Font <<
/F1 214 0 R
/F2 209 0 R
/F3 210 0 R
/F5 212 0 R
/F6 213 0 R
>>
>>
/Thumb 408 0 R
/MediaBox [0 0 595.276 790.866]
/Annots [409 0 R 410 0 R 411 0 R 412 0 R 413 0 R 414 0 R 415 0 R 416 0 R 417 0 R 418 0 R
419 0 R 420 0 R 421 0 R 422 0 R 423 0 R 424 0 R 425 0 R 426 0 R 427 0 R 428 0 R
429 0 R 430 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R 436 0 R 437 0 R 438 0 R
439 0 R 440 0 R 441 0 R 442 0 R 443 0 R 444 0 R 445 0 R 446 0 R 447 0 R 448 0 R
449 0 R 450 0 R 451 0 R 452 0 R 453 0 R 454 0 R 455 0 R 456 0 R]
/Rotate 0
>>
endobj
35 0 obj
<<
/D [33 0 R /FitR 0 207 596 207]
>>
endobj
36 0 obj
<<
/D [23 0 R /FitR 0 505 596 505]
>>
endobj
37 0 obj
<<
/D [23 0 R /FitR 0 442 596 442]
>>
endobj
38 0 obj
<<
/D [23 0 R /FitR 0 367 596 367]
>>
endobj
39 0 obj
<<
/D [23 0 R /FitR 0 268 596 268]
>>
endobj
40 0 obj
<<
/D [23 0 R /FitR 0 525 596 525]
>>
endobj
41 0 obj
<<
/D [33 0 R /FitR 0 651 596 651]
>>
endobj
42 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
43 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
44 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
45 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
46 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
47 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
48 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
49 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
50 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
51 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
52 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
53 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
54 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
55 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
56 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
57 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
58 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
59 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
60 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
61 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
62 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
63 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
64 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
65 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
66 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
67 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
68 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
69 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
70 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
71 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
72 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
73 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
74 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
75 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
76 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
77 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
78 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
79 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
80 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
81 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
82 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
83 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
84 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
85 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
86 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
87 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
88 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
89 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
90 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
91 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
92 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
93 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
94 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
95 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
96 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
97 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
98 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
99 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
100 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
101 0 obj
<<
/D [34 0 R /FitR 0 791 596 0]
>>
endobj
102 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
103 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
104 0 obj
<<
/D [33 0 R /FitR 0 791 596 0]
>>
endobj
105 0 obj
<<
/D [24 0 R /FitR 0 372 596 372]
>>
endobj
106 0 obj
<<
/D [24 0 R /FitR 0 312 596 312]
>>
endobj
107 0 obj
<<
/D [25 0 R /FitR 0 438 596 438]
>>
endobj
108 0 obj
<<
/D [25 0 R /FitR 0 588 596 588]
>>
endobj
109 0 obj
<<
/D [25 0 R /FitR 0 513 596 513]
>>
endobj
110 0 obj
<<
/D [25 0 R /FitR 0 648 596 648]
>>
endobj
111 0 obj
<<
/D [33 0 R /FitR 0 135 596 135]
>>
endobj
112 0 obj
<<
/D [33 0 R /FitR 0 705 596 705]
>>
endobj
113 0 obj
<<
/D [30 0 R /FitR 0 791 596 0]
>>
endobj
114 0 obj
<<
/D [33 0 R /FitR 0 239 596 239]
>>
endobj
115 0 obj
<<
/D [24 0 R /FitR 0 708 596 708]
>>
endobj
116 0 obj
<<
/D [26 0 R /FitR 0 96 596 96]
>>
endobj
117 0 obj
<<
/D [26 0 R /FitR 0 480 596 480]
>>
endobj
118 0 obj
<<
/D [26 0 R /FitR 0 180 596 180]
>>
endobj
119 0 obj
<<
/D [27 0 R /FitR 0 300 596 300]
>>
endobj
120 0 obj
<<
/D [27 0 R /FitR 0 288 596 288]
>>
endobj
121 0 obj
<<
/D [28 0 R /FitR 0 515 596 515]
>>
endobj
122 0 obj
<<
/D [29 0 R /FitR 0 492 596 492]
>>
endobj
123 0 obj
<<
/D [29 0 R /FitR 0 300 596 300]
>>
endobj
124 0 obj
<<
/D [30 0 R /FitR 0 708 596 708]
>>
endobj
125 0 obj
<<
/D [30 0 R /FitR 0 324 596 324]
>>
endobj
126 0 obj
<<
/D [24 0 R /FitR 0 456 596 456]
>>
endobj
127 0 obj
<<
/D [32 0 R /FitR 0 192 596 192]
>>
endobj
128 0 obj
<<
/D [32 0 R /FitR 0 311 596 311]
>>
endobj
129 0 obj
<<
/D [33 0 R /FitR 0 648 596 648]
>>
endobj
130 0 obj
<<
/D [33 0 R /FitR 0 264 596 264]
>>
endobj
131 0 obj
<<
/D [24 0 R /FitR 0 444 596 444]
>>
endobj
132 0 obj
<<
/D [24 0 R /FitR 0 165 596 165]
>>
endobj
133 0 obj
<<
/D [25 0 R /FitR 0 220 596 220]
>>
endobj
134 0 obj
<<
/D [25 0 R /FitR 0 380 596 380]
>>
endobj
135 0 obj
<<
/D [25 0 R /FitR 0 176 596 176]
>>
endobj
136 0 obj
<<
/D [26 0 R /FitR 0 564 596 564]
>>
endobj
137 0 obj
<<
/D [26 0 R /FitR 0 324 596 324]
>>
endobj
138 0 obj
<<
/D [28 0 R /FitR 0 791 596 0]
>>
endobj
139 0 obj
<<
/D [29 0 R /FitR 0 791 596 0]
>>
endobj
140 0 obj
<<
/D [29 0 R /FitR 0 791 596 0]
>>
endobj
141 0 obj
<<
/D [30 0 R /FitR 0 791 596 0]
>>
endobj
142 0 obj
<<
/D [31 0 R /FitR 0 791 596 0]
>>
endobj
143 0 obj
<<
/D [31 0 R /FitR 0 791 596 0]
>>
endobj
144 0 obj
<<
/D [32 0 R /FitR 0 791 596 0]
>>
endobj
145 0 obj
<<
/D [23 0 R /FitR 0 791 596 791]
>>
endobj
146 0 obj
<<
/D [23 0 R /FitR 0 791 596 791]
>>
endobj
147 0 obj
<<
/D [23 0 R /FitR 0 367 596 367]
>>
endobj
148 0 obj
<<
/D [23 0 R /FitR 0 268 596 268]
>>
endobj
149 0 obj
<<
/D [23 0 R /FitR 0 791 596 791]
>>
endobj
150 0 obj
<<
/D [33 0 R /FitR 0 791 596 791]
>>
endobj
151 0 obj
<<
/D [33 0 R /FitR 0 135 596 135]
>>
endobj
152 0 obj
<<
/D [33 0 R /FitR 0 791 596 791]
>>
endobj
153 0 obj
<<
/D [24 0 R /FitR 0 791 596 791]
>>
endobj
154 0 obj
<<
/D [26 0 R /FitR 0 96 596 96]
>>
endobj
155 0 obj
<<
/D [26 0 R /FitR 0 791 596 791]
>>
endobj
156 0 obj
<<
/D [26 0 R /FitR 0 180 596 180]
>>
endobj
157 0 obj
<<
/D [27 0 R /FitR 0 300 596 300]
>>
endobj
158 0 obj
<<
/D [27 0 R /FitR 0 288 596 288]
>>
endobj
159 0 obj
<<
/D [28 0 R /FitR 0 791 596 791]
>>
endobj
160 0 obj
<<
/D [29 0 R /FitR 0 791 596 791]
>>
endobj
161 0 obj
<<
/D [29 0 R /FitR 0 300 596 300]
>>
endobj
162 0 obj
<<
/D [30 0 R /FitR 0 791 596 791]
>>
endobj
163 0 obj
<<
/D [30 0 R /FitR 0 324 596 324]
>>
endobj
164 0 obj
<<
/D [24 0 R /FitR 0 791 596 791]
>>
endobj
165 0 obj
<<
/D [32 0 R /FitR 0 192 596 192]
>>
endobj
166 0 obj
<<
/D [32 0 R /FitR 0 311 596 311]
>>
endobj
167 0 obj
<<
/D [33 0 R /FitR 0 791 596 791]
>>
endobj
168 0 obj
<<
/D [33 0 R /FitR 0 264 596 264]
>>
endobj
169 0 obj
<<
/D [24 0 R /FitR 0 791 596 791]
>>
endobj
170 0 obj
<<
/D [24 0 R /FitR 0 165 596 165]
>>
endobj
171 0 obj
<<
/D [25 0 R /FitR 0 220 596 220]
>>
endobj
172 0 obj
<<
/D [25 0 R /FitR 0 380 596 380]
>>
endobj
173 0 obj
<<
/D [25 0 R /FitR 0 176 596 176]
>>
endobj
174 0 obj
<<
/D [26 0 R /FitR 0 791 596 791]
>>
endobj
175 0 obj
<<
/D [26 0 R /FitR 0 324 596 324]
>>
endobj
176 0 obj
<<
/D [33 0 R /FitR 0 207 596 207]
>>
endobj
177 0 obj
<<
/Next 18 0 R
/C [0 0 0]
/Parent 3 0 R
/F 0
/Title
/Dest
/Prev 457 0 R
/Count 0
>>
endobj
178 0 obj
<<
/Next 458 0 R
/C [0 0 0]
/Parent 3 0 R
/F 0
/Title
/Dest
/Prev 19 0 R
/Count 10
/Last 459 0 R
/First 460 0 R
>>
endobj
179 0 obj
<<
/Next 20 0 R
/C [0 0 0]
/Parent 11 0 R
/F 0
/Title
/Dest
/Prev 180 0 R
/Count 0
>>
endobj
180 0 obj
<<
/Next 179 0 R
/C [0 0 0]
/Parent 11 0 R
/F 0
/Title
/Dest
/Prev 21 0 R
/Count 0
>>
endobj
181 0 obj
<<
/Length 1802
/Filter /FlateDecode
>>
stream
xX[SF2>t>iƒS
/-,I
={vucv;|KP]+vr{7*t\ЋzKôXv]
oxJWS=N
-hiUn{]MZiT&zŷ3z4=
۵y76zA62'~Y],wKL, %-sK>ܸ,=˾d
im7W2C7H\6WxaskӽY`e18gmIb!3sshy5P5=u^`9%856=˳%xo![`mxV3>6և0~2p3s_]9E(vlؙF&ju ]ESiZj竵jVͲڨi|0Msb`-M7qDUG4~4l\?!\=:r\:a9ӸS\Fl,0tKvq:`!2S Ħ\hyd
۾=]~"R,eD
o dXC`7;'%1WZ+sxtK[@<#[1rk)⺉r} to|.bc3#uOlY4ydgz$|֪m>˃aCi }#NE9М3"ccW_4vf SៈXetS;eOtpH3 o.IJZl%3D+eG
ٜvm{ΫsQ9=(}L'
V^"jmO5JDBVkiƷE-g030A31Bl%',qtw22:%bD1#e%gQi}IT'l0ҴlJBƥn(:umY2=A!H3B7YyaK`o@]'UP~Q~S~SQS:iK$T4\yX@}lnr
Y2^{YjVD|g`$ۄ'wD<-&YԣK;t*lΈ̘2-͝z9wjz')l2XvOD077,-mtpt65LX/K.r!(;Pŗ P#b=\X_G
ItI0$"&
XxxХdjVE0WgH>`)'~KɃ`.Dk
\eHǑ֦`U3ҕr(/dJ<ڢC:_F%甸5;HY5c!v4R?D-{,(C3w\L?>RhFHOPQ%?]H?ԌDb
`^^m|R(ha;o+Xy*Zh@%
endstream
endobj
182 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
183 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
184 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
185 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /QXENXJ+LiberationSans
/Encoding /Identity-H
/DescendantFonts [461 0 R]
/ToUnicode 462 0 R
>>
endobj
186 0 obj
<<
/Length 178
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Image5 463 0 R
>>
/Font <<
/F1 464 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
xm
0F@uIzFJA*lCmŷ7gp\?\!9[_3Ji96hf]?ܒ,ŝ3"+-ʙ,k4'6R0-g0 4;̞) S!-2ߒMHS4N
endstream
endobj
187 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1186/s13063-016-1532-9)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 536 183.19 546]
>>
endobj
188 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1186/s13063-016-1532-9)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [235.09 421 424.65 431]
>>
endobj
189 0 obj
<<
/A <<
/S /URI
/URI (https://birmingham.elsevierpure.com/en/publications/35e42a4c-377e-4752-94b0-4c4cc10d4993)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 351 291.54 361]
>>
endobj
190 0 obj
<<
/Length 879
/Filter /FlateDecode
>>
stream
HWn1Mc e Bb P8?;N2i醏p~>>}?orGSzUٜB56SOo^O4:]Wb'jbT@
Cj5"94BR_PHcI#*93adt>l1ȗZ7m)6Ee/9.fJ9[lPƨ8HxQC$6ֻL0$
nHtaA ּAbKI|/a`' 鳈M\
fJ|]eJ/
|xEզ"g:j%
aLy(y=A⽈l~`N
HVv6{g\ˬ+x]j$g:~jT
}>X3mC wK7~霅Vor(o0 XH
endstream
endobj
191 0 obj
<<
/Length 604
/Filter /FlateDecode
>>
stream
HWM0W"wmB8v;MSHJPBԃgly7c\
)4r\i!U
?a" %5b"2o x>شbFv-~9.кD+c
jC!"Xy#;mpW!yEף?_ǦYO2yemʢ_}濠O'W!fXFx`??ȍ eu%_їh.$Bp(MT@49X,
-.^~Ѱ|7JMu@>Fs|<1Ĥ|(B=@$ᐂ- 8d8wI2$M0$=$ؿ< ) $@R#+FJ"eOcV*!^b.C(HOl^S=)LBQ&CZjfg[26#37dis*[=ZHYBKFZ%~vSn7{ǫlYby߬VsmlB)T@Zt,?&ް-tw N`
endstream
endobj
192 0 obj
<<
/Length 1376
/Filter /FlateDecode
>>
stream
HWɎe5ݿ?P!GB,> zS *Tҫ'p8,WhԶBޗOog/ `PVb"u%1x{6|UXK pVc@Ze5X^ZZ(@*k#t]}\Lj"EY^
qD0r+7M+v3Pn`QsljJ
`AKA]v}-)