%PDF-1.5
%
1 0 obj
<<
/Metadata 2 0 R
/Pages 3 0 R
/Type /Catalog
>>
endobj
4 0 obj
<<
/CreationDate (D:20111108103315+08'00')
/Creator (3B2 Total Publishing System 7.51n/W)
/ModDate (D:20150928131413+01'00')
/Producer (Acrobat Distiller 9.0.0 \(Windows\))
/Title (pone.0027618 1..14)
>>
endobj
2 0 obj
<<
/Length 3351
/Subtype /XML
/Type /Metadata
>>
stream
Acrobat Distiller 9.0.0 (Windows)
2011-11-08T10:33:15+08:00
3B2 Total Publishing System 7.51n/W
2015-09-28T13:14:13+01:00
2015-09-28T13:14:13+01:00
uuid:baa59e87-66d6-42d7-8d05-6007b45dfc72
uuid:1055e02b-ad1f-474f-b388-97f7124a0272
application/pdf
pone.0027618 1..14
endstream
endobj
3 0 obj
<<
/Count 15
/Kids [5 0 R 6 0 R]
/Type /Pages
>>
endobj
5 0 obj
<<
/Count 11
/Kids [7 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R
17 0 R]
/Parent 3 0 R
/Type /Pages
>>
endobj
6 0 obj
<<
/Count 4
/Kids [18 0 R 19 0 R 20 0 R 21 0 R]
/Parent 3 0 R
/Type /Pages
>>
endobj
7 0 obj
<<
/Contents 22 0 R
/Type /Page
/Resources <<
/Font <<
/F1 23 0 R
/F2 24 0 R
/F3 25 0 R
/F4 26 0 R
>>
/XObject <<
/Xf1 27 0 R
>>
>>
/Annots [28 0 R 29 0 R 30 0 R]
/Parent 5 0 R
/MediaBox [0 0 595 842]
>>
endobj
8 0 obj
<<
/Contents [31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R]
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 39 0 R
/Rotate 0
/Type /Page
>>
endobj
9 0 obj
<<
/Contents 40 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 41 0 R
/Rotate 0
/Type /Page
>>
endobj
10 0 obj
<<
/Contents 42 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 43 0 R
/Rotate 0
/Type /Page
>>
endobj
11 0 obj
<<
/Contents 44 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 45 0 R
/Rotate 0
/Type /Page
>>
endobj
12 0 obj
<<
/Contents 46 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 47 0 R
/Rotate 0
/Type /Page
>>
endobj
13 0 obj
<<
/Contents 48 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 49 0 R
/Rotate 0
/Type /Page
>>
endobj
14 0 obj
<<
/Contents 50 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 51 0 R
/Rotate 0
/Type /Page
>>
endobj
15 0 obj
<<
/Contents 52 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 53 0 R
/Rotate 0
/Type /Page
>>
endobj
16 0 obj
<<
/Contents 54 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 55 0 R
/Rotate 0
/Type /Page
>>
endobj
17 0 obj
<<
/Contents 56 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 5 0 R
/Resources 57 0 R
/Rotate 0
/Type /Page
>>
endobj
18 0 obj
<<
/Contents 58 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 6 0 R
/Resources 59 0 R
/Rotate 0
/Type /Page
>>
endobj
19 0 obj
<<
/Contents 60 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 6 0 R
/Resources 61 0 R
/Rotate 0
/Type /Page
>>
endobj
20 0 obj
<<
/Contents 62 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 6 0 R
/Resources 63 0 R
/Rotate 0
/Type /Page
>>
endobj
21 0 obj
<<
/Contents 64 0 R
/CropBox [0 0 612.28302 790.866028]
/MediaBox [0 0 612.28302 790.866028]
/Parent 6 0 R
/Resources 65 0 R
/Rotate 0
/Type /Page
>>
endobj
22 0 obj
<<
/Length 2067
/Filter /FlateDecode
>>
stream
xXIoF&CC0!K/ #mBKhDIg
y;3]"Uop4(bY*aٽm#Q 2\/qչT
5Q.踫?*k%ou>~OÙoaem^CZJzV:iBI:wwYq|8 i]2BʞS.mwg6\\|Znx.=WN;,u?;K;7"*H2E#~PQ>[0s-,V;тs.;A`ƝoZpeUap,bvm^ھ
belMhnЈ]~~`mK.[pcPa.\11w1y*c_գE4ڧZ|Zk)̗W03T-|o[!νsS@.d8}s~g۷Kfnc!L
=7WF$n],<'@Jf/u4r*VMJS
#C^;~
J]1]2{ƶW^wCy'xǶb8TFT.~t|Ɵ2qhg
Jǹ^4p=ؓW8l&y.frIgq-=)(dNt!8@ONEv[HjH̭FDf2F8nFRl-^H$oLO(AKDŽ,UO~3]&S
x7C/3ÑW֚f%Wd_W!H.W+9ٮ[k*<*41&xx'A?!tңʄ.ۧg»Q6f[X3`zP)a8%{K`Oc۴ဒpcNVeH7&/>ʈN7°^_T6#Vס1P 8axLThtR0(M#c2ˈ,#3=OdO
{|"#5mV'J-xylO %!2=Cќ_e9Ծ z)N!!!$ʲb&S41av3NԚ6mWr]ysfd')+=@$@rɒshhf~'eGQ~J5+b:BK]_0mV^G"M9(B;^)lƌȂRDn[~XufയI5jF y+)r.SaρmFȥ(ȨWXZʩOsGT 1HYMxDͼ-A(~(#:OAB0U~OI;3vƗcWIv;.t#]&4²nU:uʍٵhÒB)_oYS`?ьreHXB$ڢ8#Ut|Gd9ѡOH*e㘼R;
D$ztk(jpE$L(<fXP bCvNTmŠ+SҍsFSd,CKƚ@Q)߂{>QQeB>ۇFf5'^61T&հ(4oG%|2÷8 ^tb=xƄe.u*!!ǯ(4U7[ir_z4MI3s'wYKXZ}EWOjLڟK
endstream
endobj
23 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
24 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
25 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
26 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /ICRNRM+LiberationSans
/Encoding /Identity-H
/DescendantFonts [66 0 R]
/ToUnicode 67 0 R
>>
endobj
27 0 obj
<<
/Length 178
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Image5 68 0 R
>>
/Font <<
/F1 69 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
xm
0F@uIzFJA*lCmŷ7gp\?\!9[_3Ji96hf]?ܒ,ŝ3"+-ʙ,k4'6R0-g0 4;̞) S!-2ߒMHS4N
endstream
endobj
28 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1371/journal.pone.0027618)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 556 192.65 566]
>>
endobj
29 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1371/journal.pone.0027618)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 431 256.02 441]
>>
endobj
30 0 obj
<<
/A <<
/S /URI
/URI (https://birmingham.elsevierpure.com/en/publications/79c09f22-18f9-4983-ac36-18e2b1440b1a)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 371 291.54 381]
>>
endobj
31 0 obj
<<
/Length 2647
/Filter /FlateDecode
>>
stream
HWv8+D4c8NY$!H|Q*P29^zU'1K9Yv'6bk&6'LbIN#ZIDyl߶(Qj8bugI~b(NaVJDRۉLTZ⿔G#JdE5sǧH}map\ 3I
K(δNp~lMM^܇c6m%6wo~V!>Iv~XWstw05Ģ#>.[:ArѳYKMP,3