%PDF-1.6
%
1 0 obj
<<
/Pages 2 0 R
/Type /Catalog
/Names <<
/Dests 3 0 R
>>
/Lang (en)
/Metadata 4 0 R
>>
endobj
5 0 obj
<<
/Title (The chromatin insulator CTCF regulates HPV18 transcript splicing and differentiation-dependent late gene expression)
/Creator (Arbortext Advanced Print Publisher 11.0.3521/W Unicode-x64)
/Producer (PDFlib+PDI 9.0.6 \(C++/Win64\))
/EPSprocessor (PStill version 1.84.36)
/CreationDate (D:20211106134254+05'30')
/Author <4A61636B204665726775736F6E2C204B6172656E2043616D706F732D4C65F36E2C204965697368612050656E746C616E642C204A6F616E6E6520442E2053746F636B746F6E2C2054686F6D61732047FC6E746865722C20416E6472657720442E2042656767732C204164616D204772756E64686F66662C2053616C6C7920526F62657274732C20426F726973204E6F79766572742C204A6F616E6E61204C2E20506172697368>
/ModDate (D:20211106134254+05'30')
>>
endobj
2 0 obj
<<
/Type /Pages
/ITXT (4.1.6)
/Kids [6 0 R 7 0 R 8 0 R]
/Count 26
>>
endobj
3 0 obj
<<
/Kids [9 0 R 10 0 R 11 0 R 12 0 R 13 0 R]
>>
endobj
4 0 obj
<<
/Length 1923
/Type /Metadata
/Subtype /XML
>>
stream
doi:10.1371/journal.ppat.1010032
Jack Ferguson, Karen Campos-León, Ieisha Pentland, Joanne D. Stockton, Thomas Günther, Andrew D. Beggs, Adam Grundhoff, Sally Roberts, Boris Noyvert, Joanna L. Parish
The chromatin insulator CTCF regulates HPV18 transcript splicing and differentiation-dependent late gene expression
10.1371/journal.ppat.1010032
http://dx.doi.org/10.1371/journal.ppat.1010032
2021-11-16
false
10.1371/journal.ppat.1010032
www.plospathogens.org
10.1371/journal.ppat.1010032
2021-11-16
false
www.plospathogens.org
endstream
endobj
6 0 obj
<<
/Type /Pages
/Kids [14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R
24 0 R]
/Parent 2 0 R
/Count 11
>>
endobj
7 0 obj
<<
/Type /Pages
/Kids [25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R]
/Parent 2 0 R
/Count 10
>>
endobj
8 0 obj
<<
/Type /Pages
/Kids [35 0 R 36 0 R 37 0 R 38 0 R 39 0 R]
/Parent 2 0 R
/Count 5
>>
endobj
9 0 obj
<<
/Names [(Lppat.1010032.g001) 40 0 R (Lppat.1010032.g002) 41 0 R (Lppat.1010032.g003) 42 0 R (Lppat.1010032.g004) 43 0 R (Lppat.1010032.g005) 44 0 R
(Lppat.1010032.g006) 45 0 R (Lppat.1010032.g007) 46 0 R (Lppat.1010032.g008) 47 0 R (Lppat.1010032.ref001) 48 0 R (Lppat.1010032.ref002) 49 0 R
(Lppat.1010032.ref003) 50 0 R (Lppat.1010032.ref004) 51 0 R (Lppat.1010032.ref005) 52 0 R (Lppat.1010032.ref006) 53 0 R (Lppat.1010032.ref007) 54 0 R
(Lppat.1010032.ref008) 55 0 R (Lppat.1010032.ref009) 56 0 R (Lppat.1010032.ref010) 57 0 R (Lppat.1010032.ref011) 58 0 R (Lppat.1010032.ref012) 59 0 R
(Lppat.1010032.ref013) 60 0 R (Lppat.1010032.ref014) 61 0 R (Lppat.1010032.ref015) 62 0 R (Lppat.1010032.ref016) 63 0 R (Lppat.1010032.ref017) 64 0 R
(Lppat.1010032.ref018) 65 0 R (Lppat.1010032.ref019) 66 0 R (Lppat.1010032.ref020) 67 0 R (Lppat.1010032.ref022) 68 0 R (Lppat.1010032.ref023) 69 0 R
(Lppat.1010032.ref024) 70 0 R (Lppat.1010032.ref025) 71 0 R]
/Limits [(Lppat.1010032.g001) (Lppat.1010032.ref025)]
>>
endobj
10 0 obj
<<
/Names [(Lppat.1010032.ref026) 72 0 R (Lppat.1010032.ref027) 73 0 R (Lppat.1010032.ref028) 74 0 R (Lppat.1010032.ref030) 75 0 R (Lppat.1010032.ref031) 76 0 R
(Lppat.1010032.ref032) 77 0 R (Lppat.1010032.ref033) 78 0 R (Lppat.1010032.ref034) 79 0 R (Lppat.1010032.ref035) 80 0 R (Lppat.1010032.ref036) 81 0 R
(Lppat.1010032.ref037) 82 0 R (Lppat.1010032.ref038) 83 0 R (Lppat.1010032.ref039) 84 0 R (Lppat.1010032.ref040) 85 0 R (Lppat.1010032.ref041) 86 0 R
(Lppat.1010032.ref042) 87 0 R (Lppat.1010032.ref043) 88 0 R (Lppat.1010032.ref044) 89 0 R (Lppat.1010032.ref045) 90 0 R (Lppat.1010032.ref046) 91 0 R
(Lppat.1010032.s001) 92 0 R (Lppat.1010032.s002) 93 0 R (Lppat.1010032.s003) 94 0 R (Lppat.1010032.s004) 95 0 R (Lppat.1010032.s005) 96 0 R
(Lppat.1010032.s006) 97 0 R (Lppat.1010032.s007) 98 0 R (Lppat.1010032.s008) 99 0 R (Lppat.1010032.t001) 100 0 R (Lppat.1010032.t002) 101 0 R
(Lsec015) 102 0 R (Rppat.1010032.e001) 103 0 R]
/Limits [(Lppat.1010032.ref026) (Rppat.1010032.e001)]
>>
endobj
11 0 obj
<<
/Names [(Rppat.1010032.g001) 104 0 R (Rppat.1010032.g002) 105 0 R (Rppat.1010032.g003) 106 0 R (Rppat.1010032.g004) 107 0 R (Rppat.1010032.g005) 108 0 R
(Rppat.1010032.g006) 109 0 R (Rppat.1010032.g007) 110 0 R (Rppat.1010032.g008) 111 0 R (Rppat.1010032.ref001) 112 0 R (Rppat.1010032.ref002) 113 0 R
(Rppat.1010032.ref003) 114 0 R (Rppat.1010032.ref004) 115 0 R (Rppat.1010032.ref005) 116 0 R (Rppat.1010032.ref006) 117 0 R (Rppat.1010032.ref007) 118 0 R
(Rppat.1010032.ref008) 119 0 R (Rppat.1010032.ref009) 120 0 R (Rppat.1010032.ref010) 121 0 R (Rppat.1010032.ref011) 122 0 R (Rppat.1010032.ref012) 123 0 R
(Rppat.1010032.ref013) 124 0 R (Rppat.1010032.ref014) 125 0 R (Rppat.1010032.ref015) 126 0 R (Rppat.1010032.ref016) 127 0 R (Rppat.1010032.ref017) 128 0 R
(Rppat.1010032.ref018) 129 0 R (Rppat.1010032.ref019) 130 0 R (Rppat.1010032.ref020) 131 0 R (Rppat.1010032.ref021) 132 0 R (Rppat.1010032.ref022) 133 0 R
(Rppat.1010032.ref023) 134 0 R (Rppat.1010032.ref024) 135 0 R]
/Limits [(Rppat.1010032.g001) (Rppat.1010032.ref024)]
>>
endobj
12 0 obj
<<
/Names [(Rppat.1010032.ref025) 136 0 R (Rppat.1010032.ref026) 137 0 R (Rppat.1010032.ref027) 138 0 R (Rppat.1010032.ref028) 139 0 R (Rppat.1010032.ref029) 140 0 R
(Rppat.1010032.ref030) 141 0 R (Rppat.1010032.ref031) 142 0 R (Rppat.1010032.ref032) 143 0 R (Rppat.1010032.ref033) 144 0 R (Rppat.1010032.ref034) 145 0 R
(Rppat.1010032.ref035) 146 0 R (Rppat.1010032.ref036) 147 0 R (Rppat.1010032.ref037) 148 0 R (Rppat.1010032.ref038) 149 0 R (Rppat.1010032.ref039) 150 0 R
(Rppat.1010032.ref040) 151 0 R (Rppat.1010032.ref041) 152 0 R (Rppat.1010032.ref042) 153 0 R (Rppat.1010032.ref043) 154 0 R (Rppat.1010032.ref044) 155 0 R
(Rppat.1010032.ref045) 156 0 R (Rppat.1010032.ref046) 157 0 R (Rppat.1010032.s001) 158 0 R (Rppat.1010032.s002) 159 0 R (Rppat.1010032.s003) 160 0 R
(Rppat.1010032.s004) 161 0 R (Rppat.1010032.s005) 162 0 R (Rppat.1010032.s006) 163 0 R (Rppat.1010032.s007) 164 0 R (Rppat.1010032.s008) 165 0 R
(Rppat.1010032.t001) 166 0 R (Rppat.1010032.t002) 167 0 R]
/Limits [(Rppat.1010032.ref025) (Rppat.1010032.t002)]
>>
endobj
13 0 obj
<<
/Names [(Rsec001) 168 0 R (Rsec002) 169 0 R (Rsec003) 170 0 R (Rsec004) 171 0 R (Rsec005) 172 0 R
(Rsec006) 173 0 R (Rsec007) 174 0 R (Rsec008) 175 0 R (Rsec009) 176 0 R (Rsec010) 177 0 R
(Rsec011) 178 0 R (Rsec012) 179 0 R (Rsec013) 180 0 R (Rsec014) 181 0 R (Rsec015) 182 0 R]
/Limits [(Rsec001) (Rsec015)]
>>
endobj
14 0 obj
<<
/Contents 183 0 R
/Type /Page
/Resources <<
/Font <<
/F1 184 0 R
/F2 185 0 R
/F3 186 0 R
/F4 187 0 R
>>
/XObject <<
/Xf1 188 0 R
>>
>>
/Annots [189 0 R 190 0 R 191 0 R]
/Parent 6 0 R
/MediaBox [0 0 595 842]
>>
endobj
15 0 obj
<<
/Type /Page
/Contents 192 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 193 0 R
/TrimBox [0 0 612 792]
/Annots [194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R
204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R]
>>
endobj
16 0 obj
<<
/Type /Page
/Contents 212 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 213 0 R
/TrimBox [0 0 612 792]
/Annots [214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R 222 0 R 223 0 R
224 0 R 225 0 R 226 0 R 227 0 R]
>>
endobj
17 0 obj
<<
/Type /Page
/Contents 228 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 229 0 R
/TrimBox [0 0 612 792]
/Annots [230 0 R 231 0 R 232 0 R 233 0 R 234 0 R 235 0 R 236 0 R 237 0 R 238 0 R 239 0 R
240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R
250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R]
>>
endobj
18 0 obj
<<
/Type /Page
/Contents 256 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 257 0 R
/TrimBox [0 0 612 792]
/Annots [258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R]
>>
endobj
19 0 obj
<<
/Type /Page
/Contents 267 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 268 0 R
/TrimBox [0 0 612 792]
/Annots [269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R 275 0 R 276 0 R]
>>
endobj
20 0 obj
<<
/Type /Page
/Contents 277 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 278 0 R
/TrimBox [0 0 612 792]
/Annots [279 0 R 280 0 R 281 0 R 282 0 R 283 0 R 284 0 R 285 0 R 286 0 R 287 0 R 288 0 R
289 0 R]
>>
endobj
21 0 obj
<<
/Type /Page
/Contents 290 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 291 0 R
/TrimBox [0 0 612 792]
/Annots [292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R 301 0 R
302 0 R 303 0 R]
>>
endobj
22 0 obj
<<
/Type /Page
/Contents 304 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 305 0 R
/TrimBox [0 0 612 792]
/Annots [306 0 R 307 0 R 308 0 R]
>>
endobj
23 0 obj
<<
/Type /Page
/Contents 309 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 310 0 R
/TrimBox [0 0 612 792]
/Annots [311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R 317 0 R 318 0 R 319 0 R 320 0 R
321 0 R 322 0 R 323 0 R 324 0 R 325 0 R 326 0 R 327 0 R 328 0 R]
>>
endobj
24 0 obj
<<
/Type /Page
/Contents 329 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 6 0 R
/Resources 330 0 R
/TrimBox [0 0 612 792]
/Annots [331 0 R 332 0 R 333 0 R]
>>
endobj
25 0 obj
<<
/Type /Page
/Contents 334 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 335 0 R
/TrimBox [0 0 612 792]
/Annots [336 0 R 337 0 R 338 0 R 339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R
346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R
356 0 R 357 0 R 358 0 R 359 0 R 360 0 R]
>>
endobj
26 0 obj
<<
/Type /Page
/Contents 361 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 362 0 R
/TrimBox [0 0 612 792]
/Annots [363 0 R 364 0 R 365 0 R 366 0 R 367 0 R 368 0 R 369 0 R 370 0 R]
>>
endobj
27 0 obj
<<
/Type /Page
/Contents 371 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 372 0 R
/TrimBox [0 0 612 792]
/Annots [373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R 382 0 R
383 0 R]
>>
endobj
28 0 obj
<<
/Type /Page
/Contents 384 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 385 0 R
/TrimBox [0 0 612 792]
/Annots [386 0 R 387 0 R 388 0 R]
>>
endobj
29 0 obj
<<
/Type /Page
/Contents 389 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 390 0 R
/TrimBox [0 0 612 792]
/Annots [391 0 R 392 0 R 393 0 R 394 0 R 395 0 R 396 0 R 397 0 R 398 0 R 399 0 R 400 0 R
401 0 R 402 0 R 403 0 R 404 0 R 405 0 R 406 0 R]
>>
endobj
30 0 obj
<<
/Type /Page
/Contents 407 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 408 0 R
/TrimBox [0 0 612 792]
/Annots [409 0 R 410 0 R 411 0 R 412 0 R]
>>
endobj
31 0 obj
<<
/Type /Page
/Contents 413 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 414 0 R
/TrimBox [0 0 612 792]
/Annots [415 0 R 416 0 R]
>>
endobj
32 0 obj
<<
/Type /Page
/Contents 417 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 418 0 R
/TrimBox [0 0 612 792]
/Annots [419 0 R 420 0 R 421 0 R 422 0 R 423 0 R]
>>
endobj
33 0 obj
<<
/Type /Page
/Contents 424 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 425 0 R
/TrimBox [0 0 612 792]
/Annots [426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R
436 0 R 437 0 R 438 0 R 439 0 R]
>>
endobj
34 0 obj
<<
/Type /Page
/Contents 440 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 7 0 R
/Resources 441 0 R
/TrimBox [0 0 612 792]
/Annots [442 0 R 443 0 R 444 0 R 445 0 R 446 0 R 447 0 R 448 0 R]
>>
endobj
35 0 obj
<<
/Type /Page
/Contents 449 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 8 0 R
/Resources 450 0 R
/TrimBox [0 0 612 792]
/Annots [451 0 R 452 0 R 453 0 R 454 0 R 455 0 R 456 0 R 457 0 R]
>>
endobj
36 0 obj
<<
/Type /Page
/Contents 458 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 8 0 R
/Resources 459 0 R
/TrimBox [0 0 612 792]
/Annots [460 0 R 461 0 R 462 0 R 463 0 R 464 0 R 465 0 R 466 0 R 467 0 R 468 0 R 469 0 R
470 0 R 471 0 R 472 0 R 473 0 R 474 0 R 475 0 R 476 0 R 477 0 R 478 0 R 479 0 R
480 0 R 481 0 R 482 0 R 483 0 R 484 0 R 485 0 R 486 0 R 487 0 R 488 0 R 489 0 R]
>>
endobj
37 0 obj
<<
/Type /Page
/Contents 490 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 8 0 R
/Resources 491 0 R
/TrimBox [0 0 612 792]
/Annots [492 0 R 493 0 R 494 0 R 495 0 R 496 0 R 497 0 R 498 0 R 499 0 R 500 0 R 501 0 R
502 0 R 503 0 R 504 0 R 505 0 R 506 0 R 507 0 R 508 0 R 509 0 R 510 0 R 511 0 R
512 0 R 513 0 R 514 0 R 515 0 R 516 0 R 517 0 R 518 0 R 519 0 R 520 0 R 521 0 R
522 0 R 523 0 R 524 0 R 525 0 R 526 0 R 527 0 R 528 0 R 529 0 R 530 0 R 531 0 R
532 0 R 533 0 R 534 0 R 535 0 R 536 0 R 537 0 R 538 0 R 539 0 R 540 0 R 541 0 R
542 0 R 543 0 R 544 0 R 545 0 R 546 0 R 547 0 R 548 0 R 549 0 R]
>>
endobj
38 0 obj
<<
/Type /Page
/Contents 550 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 8 0 R
/Resources 551 0 R
/TrimBox [0 0 612 792]
/Annots [552 0 R 553 0 R 554 0 R 555 0 R 556 0 R 557 0 R 558 0 R 559 0 R 560 0 R 561 0 R
562 0 R 563 0 R 564 0 R 565 0 R 566 0 R 567 0 R 568 0 R 569 0 R 570 0 R 571 0 R
572 0 R 573 0 R 574 0 R 575 0 R 576 0 R 577 0 R 578 0 R 579 0 R 580 0 R 581 0 R
582 0 R 583 0 R 584 0 R 585 0 R 586 0 R 587 0 R 588 0 R 589 0 R 590 0 R 591 0 R
592 0 R 593 0 R 594 0 R 595 0 R 596 0 R 597 0 R 598 0 R 599 0 R 600 0 R 601 0 R
602 0 R 603 0 R 604 0 R 605 0 R 606 0 R 607 0 R 608 0 R 609 0 R 610 0 R]
>>
endobj
39 0 obj
<<
/Type /Page
/Contents 611 0 R
/CropBox [0 0 612 792]
/MediaBox [0 0 612 792]
/Parent 8 0 R
/Resources 612 0 R
/TrimBox [0 0 612 792]
/Annots [613 0 R 614 0 R 615 0 R 616 0 R 617 0 R 618 0 R 619 0 R 620 0 R 621 0 R 622 0 R
623 0 R 624 0 R]
>>
endobj
40 0 obj
<<
/D [21 0 R /FitR 0 461.078 612 461.078]
>>
endobj
41 0 obj
<<
/D [23 0 R /FitR 0 314.575 612 314.575]
>>
endobj
42 0 obj
<<
/D [25 0 R /FitR 0 331.48 612 331.48]
>>
endobj
43 0 obj
<<
/D [26 0 R /FitR 0 369.289 612 369.289]
>>
endobj
44 0 obj
<<
/D [27 0 R /FitR 0 269.63 612 269.63]
>>
endobj
45 0 obj
<<
/D [29 0 R /FitR 0 760.479 612 760.479]
>>
endobj
46 0 obj
<<
/D [29 0 R /FitR 0 461.48 612 461.48]
>>
endobj
47 0 obj
<<
/D [30 0 R /FitR 0 293.124 612 293.124]
>>
endobj
48 0 obj
<<
/D [16 0 R /FitR 0 617.078 612 617.078]
>>
endobj
49 0 obj
<<
/D [16 0 R /FitR 0 578.078 612 578.078]
>>
endobj
50 0 obj
<<
/D [16 0 R /FitR 0 513.078 612 513.078]
>>
endobj
51 0 obj
<<
/D [17 0 R /FitR 0 734.479 612 734.479]
>>
endobj
52 0 obj
<<
/D [16 0 R /FitR 0 435.078 612 435.078]
>>
endobj
53 0 obj
<<
/D [16 0 R /FitR 0 279.079 612 279.079]
>>
endobj
54 0 obj
<<
/D [16 0 R /FitR 0 331.078 612 331.078]
>>
endobj
55 0 obj
<<
/D [16 0 R /FitR 0 318.078 612 318.078]
>>
endobj
56 0 obj
<<
/D [17 0 R /FitR 0 786.479 612 786.479]
>>
endobj
57 0 obj
<<
/D [17 0 R /FitR 0 760.479 612 760.479]
>>
endobj
58 0 obj
<<
/D [17 0 R /FitR 0 747.479 612 747.479]
>>
endobj
59 0 obj
<<
/D [17 0 R /FitR 0 734.479 612 734.479]
>>
endobj
60 0 obj
<<
/D [17 0 R /FitR 0 734.479 612 734.479]
>>
endobj
61 0 obj
<<
/D [17 0 R /FitR 0 695.479 612 695.479]
>>
endobj
62 0 obj
<<
/D [17 0 R /FitR 0 695.479 612 695.479]
>>
endobj
63 0 obj
<<
/D [17 0 R /FitR 0 669.479 612 669.479]
>>
endobj
64 0 obj
<<
/D [17 0 R /FitR 0 643.479 612 643.479]
>>
endobj
65 0 obj
<<
/D [17 0 R /FitR 0 591.479 612 591.479]
>>
endobj
66 0 obj
<<
/D [25 0 R /FitR 0 656.479 612 656.479]
>>
endobj
67 0 obj
<<
/D [17 0 R /FitR 0 539.48 612 539.48]
>>
endobj
68 0 obj
<<
/D [17 0 R /FitR 0 539.48 612 539.48]
>>
endobj
69 0 obj
<<
/D [17 0 R /FitR 0 487.48 612 487.48]
>>
endobj
70 0 obj
<<
/D [17 0 R /FitR 0 461.48 612 461.48]
>>
endobj
71 0 obj
<<
/D [17 0 R /FitR 0 435.48 612 435.48]
>>
endobj
72 0 obj
<<
/D [17 0 R /FitR 0 422.48 612 422.48]
>>
endobj
73 0 obj
<<
/D [17 0 R /FitR 0 318.48 612 318.48]
>>
endobj
74 0 obj
<<
/D [17 0 R /FitR 0 292.48 612 292.48]
>>
endobj
75 0 obj
<<
/D [18 0 R /FitR 0 401.429 612 401.429]
>>
endobj
76 0 obj
<<
/D [18 0 R /FitR 0 388.429 612 388.429]
>>
endobj
77 0 obj
<<
/D [19 0 R /FitR 0 422.078 612 422.078]
>>
endobj
78 0 obj
<<
/D [19 0 R /FitR 0 383.079 612 383.079]
>>
endobj
79 0 obj
<<
/D [19 0 R /FitR 0 370.079 612 370.079]
>>
endobj
80 0 obj
<<
/D [20 0 R /FitR 0 792 612 792]
>>
endobj
81 0 obj
<<
/D [20 0 R /FitR 0 792 612 792]
>>
endobj
82 0 obj
<<
/D [20 0 R /FitR 0 678.67 612 678.67]
>>
endobj
83 0 obj
<<
/D [20 0 R /FitR 0 652.67 612 652.67]
>>
endobj
84 0 obj
<<
/D [21 0 R /FitR 0 792 612 792]
>>
endobj
85 0 obj
<<
/D [21 0 R /FitR 0 604.078 612 604.078]
>>
endobj
86 0 obj
<<
/D [23 0 R /FitR 0 587.574 612 587.574]
>>
endobj
87 0 obj
<<
/D [23 0 R /FitR 0 275.575 612 275.575]
>>
endobj
88 0 obj
<<
/D [27 0 R /FitR 0 438.629 612 438.629]
>>
endobj
89 0 obj
<<
/D [29 0 R /FitR 0 266.48 612 266.48]
>>
endobj
90 0 obj
<<
/D [33 0 R /FitR 0 792 612 792]
>>
endobj
91 0 obj
<<
/D [22 0 R /FitR 0 278.259 612 278.259]
>>
endobj
92 0 obj
<<
/D [21 0 R /FitR 0 318.078 612 318.078]
>>
endobj
93 0 obj
<<
/D [23 0 R /FitR 0 392.575 612 392.575]
>>
endobj
94 0 obj
<<
/D [23 0 R /FitR 0 301.575 612 301.575]
>>
endobj
95 0 obj
<<
/D [25 0 R /FitR 0 786.479 612 786.479]
>>
endobj
96 0 obj
<<
/D [25 0 R /FitR 0 747.479 612 747.479]
>>
endobj
97 0 obj
<<
/D [29 0 R /FitR 0 604.479 612 604.479]
>>
endobj
98 0 obj
<<
/D [25 0 R /FitR 0 747.479 612 747.479]
>>
endobj
99 0 obj
<<
/D [25 0 R /FitR 0 747.479 612 747.479]
>>
endobj
100 0 obj
<<
/D [19 0 R /FitR 0 623.366 612 623.366]
>>
endobj
101 0 obj
<<
/D [20 0 R /FitR 0 511.181 612 511.181]
>>
endobj
102 0 obj
<<
/D [16 0 R /FitR 0 792 612 792]
>>
endobj
103 0 obj
<<
/D [19 0 R /FitR 0 597.366 612 597.366]
>>
endobj
104 0 obj
<<
/D [22 0 R /FitR 0 287.759 612 287.759]
>>
endobj
105 0 obj
<<
/D [24 0 R /FitR 0 353.039 612 353.039]
>>
endobj
106 0 obj
<<
/D [26 0 R /FitR 0 524.639 612 524.639]
>>
endobj
107 0 obj
<<
/D [27 0 R /FitR 0 630.479 612 630.479]
>>
endobj
108 0 obj
<<
/D [28 0 R /FitR 0 475.439 612 475.439]
>>
endobj
109 0 obj
<<
/D [30 0 R /FitR 0 373.975 612 373.975]
>>
endobj
110 0 obj
<<
/D [31 0 R /FitR 0 297.359 612 297.359]
>>
endobj
111 0 obj
<<
/D [32 0 R /FitR 0 296.357 612 296.357]
>>
endobj
112 0 obj
<<
/D [36 0 R /FitR 0 534.079 612 534.079]
>>
endobj
113 0 obj
<<
/D [36 0 R /FitR 0 511.579 612 511.579]
>>
endobj
114 0 obj
<<
/D [36 0 R /FitR 0 479.579 612 479.579]
>>
endobj
115 0 obj
<<
/D [36 0 R /FitR 0 447.579 612 447.579]
>>
endobj
116 0 obj
<<
/D [36 0 R /FitR 0 406.079 612 406.079]
>>
endobj
117 0 obj
<<
/D [36 0 R /FitR 0 364.579 612 364.579]
>>
endobj
118 0 obj
<<
/D [36 0 R /FitR 0 323.079 612 323.079]
>>
endobj
119 0 obj
<<
/D [36 0 R /FitR 0 281.579 612 281.579]
>>
endobj
120 0 obj
<<
/D [37 0 R /FitR 0 792 612 792]
>>
endobj
121 0 obj
<<
/D [37 0 R /FitR 0 792 612 792]
>>
endobj
122 0 obj
<<
/D [37 0 R /FitR 0 792 612 792]
>>
endobj
123 0 obj
<<
/D [37 0 R /FitR 0 773.299 612 773.299]
>>
endobj
124 0 obj
<<
/D [37 0 R /FitR 0 722.299 612 722.299]
>>
endobj
125 0 obj
<<
/D [37 0 R /FitR 0 690.299 612 690.299]
>>
endobj
126 0 obj
<<
/D [37 0 R /FitR 0 658.299 612 658.299]
>>
endobj
127 0 obj
<<
/D [37 0 R /FitR 0 616.798 612 616.798]
>>
endobj
128 0 obj
<<
/D [37 0 R /FitR 0 584.798 612 584.798]
>>
endobj
129 0 obj
<<
/D [37 0 R /FitR 0 552.798 612 552.798]
>>
endobj
130 0 obj
<<
/D [37 0 R /FitR 0 520.798 612 520.798]
>>
endobj
131 0 obj
<<
/D [37 0 R /FitR 0 479.298 612 479.298]
>>
endobj
132 0 obj
<<
/D [37 0 R /FitR 0 428.298 612 428.298]
>>
endobj
133 0 obj
<<
/D [37 0 R /FitR 0 396.298 612 396.298]
>>
endobj
134 0 obj
<<
/D [37 0 R /FitR 0 354.798 612 354.798]
>>
endobj
135 0 obj
<<
/D [37 0 R /FitR 0 322.798 612 322.798]
>>
endobj
136 0 obj
<<
/D [37 0 R /FitR 0 290.798 612 290.798]
>>
endobj
137 0 obj
<<
/D [38 0 R /FitR 0 792 612 792]
>>
endobj
138 0 obj
<<
/D [38 0 R /FitR 0 792 612 792]
>>
endobj
139 0 obj
<<
/D [38 0 R /FitR 0 792 612 792]
>>
endobj
140 0 obj
<<
/D [38 0 R /FitR 0 779.299 612 779.299]
>>
endobj
141 0 obj
<<
/D [38 0 R /FitR 0 747.299 612 747.299]
>>
endobj
142 0 obj
<<
/D [38 0 R /FitR 0 705.799 612 705.799]
>>
endobj
143 0 obj
<<
/D [38 0 R /FitR 0 673.799 612 673.799]
>>
endobj
144 0 obj
<<
/D [38 0 R /FitR 0 632.299 612 632.299]
>>
endobj
145 0 obj
<<
/D [38 0 R /FitR 0 600.299 612 600.299]
>>
endobj
146 0 obj
<<
/D [38 0 R /FitR 0 568.299 612 568.299]
>>
endobj
147 0 obj
<<
/D [38 0 R /FitR 0 536.299 612 536.299]
>>
endobj
148 0 obj
<<
/D [38 0 R /FitR 0 504.298 612 504.298]
>>
endobj
149 0 obj
<<
/D [38 0 R /FitR 0 472.298 612 472.298]
>>
endobj
150 0 obj
<<
/D [38 0 R /FitR 0 440.298 612 440.298]
>>
endobj
151 0 obj
<<
/D [38 0 R /FitR 0 408.298 612 408.298]
>>
endobj
152 0 obj
<<
/D [38 0 R /FitR 0 366.798 612 366.798]
>>
endobj
153 0 obj
<<
/D [38 0 R /FitR 0 334.798 612 334.798]
>>
endobj
154 0 obj
<<
/D [38 0 R /FitR 0 293.298 612 293.298]
>>
endobj
155 0 obj
<<
/D [39 0 R /FitR 0 792 612 792]
>>
endobj
156 0 obj
<<
/D [39 0 R /FitR 0 792 612 792]
>>
endobj
157 0 obj
<<
/D [39 0 R /FitR 0 792 612 792]
>>
endobj
158 0 obj
<<
/D [34 0 R /FitR 0 486.078 612 486.078]
>>
endobj
159 0 obj
<<
/D [34 0 R /FitR 0 337.078 612 337.078]
>>
endobj
160 0 obj
<<
/D [35 0 R /FitR 0 792 612 792]
>>
endobj
161 0 obj
<<
/D [35 0 R /FitR 0 689.479 612 689.479]
>>
endobj
162 0 obj
<<
/D [35 0 R /FitR 0 618.479 612 618.479]
>>
endobj
163 0 obj
<<
/D [35 0 R /FitR 0 534.479 612 534.479]
>>
endobj
164 0 obj
<<
/D [35 0 R /FitR 0 450.479 612 450.479]
>>
endobj
165 0 obj
<<
/D [35 0 R /FitR 0 392.479 612 392.479]
>>
endobj
166 0 obj
<<
/D [19 0 R /FitR 0 792 612 792]
>>
endobj
167 0 obj
<<
/D [20 0 R /FitR 0 329.912 612 329.912]
>>
endobj
168 0 obj
<<
/D [16 0 R /FitR 0 687.078 612 687.078]
>>
endobj
169 0 obj
<<
/D [18 0 R /FitR 0 792 612 792]
>>
endobj
170 0 obj
<<
/D [18 0 R /FitR 0 792 612 792]
>>
endobj
171 0 obj
<<
/D [18 0 R /FitR 0 723.778 612 723.778]
>>
endobj
172 0 obj
<<
/D [18 0 R /FitR 0 510.428 612 510.428]
>>
endobj
173 0 obj
<<
/D [18 0 R /FitR 0 323.078 612 323.078]
>>
endobj
174 0 obj
<<
/D [19 0 R /FitR 0 453.078 612 453.078]
>>
endobj
175 0 obj
<<
/D [20 0 R /FitR 0 792 612 792]
>>
endobj
176 0 obj
<<
/D [20 0 R /FitR 0 748.67 612 748.67]
>>
endobj
177 0 obj
<<
/D [20 0 R /FitR 0 555.181 612 555.181]
>>
endobj
178 0 obj
<<
/D [20 0 R /FitR 0 478.692 612 478.692]
>>
endobj
179 0 obj
<<
/D [21 0 R /FitR 0 792 612 792]
>>
endobj
180 0 obj
<<
/D [21 0 R /FitR 0 700.078 612 700.078]
>>
endobj
181 0 obj
<<
/D [32 0 R /FitR 0 660.677 612 660.677]
>>
endobj
182 0 obj
<<
/D [34 0 R /FitR 0 504.078 612 504.078]
>>
endobj
183 0 obj
<<
/Length 1856
/Filter /FlateDecode
>>
stream
xX[sF;}kδM,q1<`WD$٩o_Ї= VN!v\o|
TеU
]/4h`(BRoފ
\@qjhZZI&ր-jj'ǐc~<]mlg27oF۵~\ݳ^'uH3룕nvv4G6x֒=Z>tzL*<3oә^,,r]۹9>h_t℥X`,GUO*h%Ƙ-|)9o@bMf
ck̡ wv*t`ey\!ɪZ/QVWbQwssӀ3k{^?5}Bj8s=eJ`B
1@K8^W=iNSZ}t<\[3(jRGϞYo=KYۏmzтٸ
?<0fndV3j
&)X$3Ç5}0-vͳ}2l,]{4ݛl+Ǚ)$$\®i"hpExܰYdcqF>WέT:'PRKZG,J*Hk9ٌ |)ZQ|x>m
讋
XB#˩WAO]trMBkMsf
,2
sT)q}k*
@%m@++]e?])m|c5OldOU:4\(7-=)cT+SZ
>1Krk%m㺡rwdc2knAx+W'v"f7N3|q&^=6ObJRmJdYu ]w>0Ҝ>32 q_tPSJKS_X[1)2D$!0-148DKcDv-zJr 5jc;H(O\P
;>'ft+U(J~C#zDdѭ'*}yh
,QuI0RUgCʇ7ƀ Se8RaK|KkW[KƷ9"̘8'Ȕ&&Uhs *NVS&="@ # cRPrv֧vYDuc-?%MkY܇t_ȸ颃sXޕ.CQaşxmQ
rƖq/Ɉ4#j_^썑ȜR`d~rOʏa3ʵ8m0$<ߦe ϑmMΐK!Rf(QZ5ʩȯs@"HMxHyK$AL4,'gQ-Kt)|̀SbW}rz'O>rƾM
%V;\i@ 9{SS =gڌ2
IRB&fl$ğk֣Y!ntbb2vxTmQ[+&
?%ҧ,0y1y,h}~MY%ƻyi1ГJ|J0j*I>H椏J-z&*?]ȯFRO\6bSc|!Uq7EtҔN炄4 m^IH/?=ڡBrd`N!AUMD6EyC~'IٺP?]qoS(ՋJڿ4<'
endstream
endobj
184 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
185 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
186 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
187 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /BXGZJG+LiberationSans
/Encoding /Identity-H
/DescendantFonts [625 0 R]
/ToUnicode 626 0 R
>>
endobj
188 0 obj
<<
/Length 178
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject <<
/Image5 627 0 R
>>
/Font <<
/F1 628 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
xm
0F@uIzFJA*lCmŷ7gp\?\!9[_3Ji96hf]?ܒ,ŝ3"+-ʙ,k4'6R0-g0 4;̞) S!-2ߒMHS4N
endstream
endobj
189 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1371/journal.ppat.1010032)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 556 189.87 566]
>>
endobj
190 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1371/journal.ppat.1010032)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 431 253.24 441]
>>
endobj
191 0 obj
<<
/A <<
/S /URI
/URI (https://birmingham.elsevierpure.com/en/publications/80e95db4-761b-4cfb-a3e3-4aebe276ccbb)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 371 291.54 381]
>>
endobj
192 0 obj
<<
/Length 6440
/Filter /FlateDecode
>>
stream
x\ɒGr}A&Ì
/@I^`2ˮJ*P@9YzY]
t0D\"#ݟ?_ߝE,DxF~p$NY֓YEƽ=)3ƨRWd4h20lN&YY2lczeu