%PDF-1.4
%
1 0 obj
<<
/Lang (en-GB)
/Metadata 2 0 R
/Names 3 0 R
/Outlines 4 0 R
/Pages 5 0 R
/Type /Catalog
/ViewerPreferences <<
/Direction /L2R
>>
>>
endobj
6 0 obj
<<
/CreationDate (D:20211004035036+01'00')
/Creator (Adobe InDesign CC 14.0 \(Windows\))
/ModDate (D:20211006090316-07'00')
/Producer (Adobe PDF Library 15.0)
/Trapped /False
/jobID (d0c3b2c1-627d-465d-a867-fdc26b767a67)
>>
endobj
2 0 obj
<<
/Length 2916
/Subtype /XML
/Type /Metadata
>>
stream
doi:bmjopen-2021-050574
application/pdf
2021-10-04T03:50:36+01:00
2021-10-06T09:03:16-07:00
2021-10-06T09:03:16-07:00
Adobe InDesign CC 14.0 (Windows)
uuid:cdfa6777-1dd1-11b2-0a00-8800b8168aff
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
xmp.id:6d518913-d7dc-7647-b1d9-6b859c56cf36
proof:pdf
xmp.iid:ffd73948-ca85-a94f-9816-0de68de29dff
xmp.did:cebbe955-c8a8-8d41-ba80-2032a78fefce
xmp.did:B2C59A163194E611BD009A7CB80B8EC7
default
converted
from application/x-indesign to application/pdf
Adobe InDesign CC 14.0 (Windows)
/
2021-10-04T03:50:36+01:00
d0c3b2c1-627d-465d-a867-fdc26b767a67
Adobe PDF Library 15.0
False
endstream
endobj
3 0 obj
<<
/Dests 7 0 R
>>
endobj
4 0 obj
<<
/Count 10
/First 8 0 R
/Last 8 0 R
/Type /Outlines
>>
endobj
5 0 obj
<<
/Count 8
/Kids [9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R]
/Type /Pages
>>
endobj
7 0 obj
<<
/Names [(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:BLK_BX1:2105) [10 0 R /XYZ 387 575 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:BLK_F1:2101) [12 0 R /XYZ 142 475 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:BLK_F2:2102) [13 0 R /XYZ 40 398 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:BLK_F3:2103) [14 0 R /XYZ 40 539 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:BLK_F4:2104) [15 0 R /XYZ 40 585 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:BLK_T1:2100) [14 0 R /XYZ 48 330 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 10:2115) [16 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 1:2106) [10 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 2:2107) [10 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 3:2108) [10 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 4:2109) [11 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 5:2110) [11 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 6:2111) [11 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 7:2112) [12 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 8:2113) [13 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 9:2114) [15 0 R /Fit]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R10:2059) [16 0 R /XYZ 306 397 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R11:2060) [16 0 R /XYZ 306 371 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R12:2061) [16 0 R /XYZ 306 346 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R13:2062) [16 0 R /XYZ 306 320 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R14:2063) [16 0 R /XYZ 306 286 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R15:2064) [16 0 R /XYZ 306 269 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R16:2065) [16 0 R /XYZ 306 244 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R17:2066) [16 0 R /XYZ 306 218 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R18:2067) [16 0 R /XYZ 306 193 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R19:2068) [16 0 R /XYZ 306 176 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R1:2050) [16 0 R /XYZ 306 635 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R20:2069) [16 0 R /XYZ 306 150 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R21:2070) [16 0 R /XYZ 306 133 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R22:2071) [16 0 R /XYZ 306 116 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R23:2072) [16 0 R /XYZ 306 91 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R2:2051) [16 0 R /XYZ 306 609 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R3:2052) [16 0 R /XYZ 306 584 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R4:2053) [16 0 R /XYZ 306 558 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R5:2054) [16 0 R /XYZ 306 533 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R6:2055) [16 0 R /XYZ 306 507 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R7:2056) [16 0 R /XYZ 306 473 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R8:2057) [16 0 R /XYZ 306 448 null]
(d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:R9:2058) [16 0 R /XYZ 306 422 null]
]
>>
endobj
8 0 obj
<<
/A 17 0 R
/Count 9
/First 18 0 R
/Last 19 0 R
/Parent 4 0 R
/Title
>>
endobj
9 0 obj
<<
/Contents 20 0 R
/Type /Page
/Resources <<
/Font <<
/F1 21 0 R
/F2 22 0 R
/F3 23 0 R
/F4 24 0 R
>>
/XObject <<
/Xf1 25 0 R
>>
>>
/Annots [26 0 R 27 0 R 28 0 R 29 0 R]
/Parent 5 0 R
/MediaBox [0 0 595 842]
>>
endobj
10 0 obj
<<
/Annots [30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R
40 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 41 0 R
/CropBox [0.0 0.0 595.276 793.701]
/LastModified (D:20211006090316-07'00')
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/PieceInfo <<
/InDesign <<
/DocumentID
/LastModified
/NumberofPages 1
/OriginalDocumentID
/PageUIDList <<
/0 4586
>>
/PageWidthList <<
/0 595.276
>>
>>
>>
/Resources <<
/ExtGState <<
/GS0 42 0 R
/GS1 43 0 R
/GS2 44 0 R
>>
/Font <<
/C2_0 45 0 R
/C2_1 46 0 R
/T1_0 47 0 R
/T1_1 48 0 R
/T1_2 49 0 R
/T1_3 50 0 R
/T1_4 51 0 R
/T1_5 52 0 R
/T1_6 53 0 R
/T1_7 54 0 R
/T1_8 55 0 R
/TT0 56 0 R
>>
/ProcSet [/PDF /Text]
/Properties <<
/MC0 57 0 R
/MC1 58 0 R
/MC2 59 0 R
/MC3 60 0 R
>>
/Shading <<
/Sh0 61 0 R
>>
/XObject <<
/Fm0 62 0 R
/Fm1 63 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
11 0 obj
<<
/Annots [64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R
74 0 R 75 0 R 76 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 77 0 R
/CropBox [0.0 0.0 595.276 793.701]
/LastModified (D:20211006090316-07'00')
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/PieceInfo <<
/InDesign <<
/DocumentID
/LastModified
/NumberofPages 1
/OriginalDocumentID
/PageUIDList <<
/0 4853
>>
/PageWidthList <<
/0 595.276
>>
>>
>>
/Resources <<
/ExtGState <<
/GS0 42 0 R
/GS1 78 0 R
/GS2 79 0 R
>>
/Font <<
/T1_0 47 0 R
/T1_1 48 0 R
/T1_2 53 0 R
/T1_3 55 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 80 0 R
/Fm1 81 0 R
/Fm2 63 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
12 0 obj
<<
/Annots [82 0 R 83 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 84 0 R
/CropBox [0.0 0.0 595.276 793.701]
/LastModified (D:20211006090316-07'00')
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/PieceInfo <<
/InDesign <<
/DocumentID
/LastModified
/NumberofPages 1
/OriginalDocumentID
/PageUIDList <<
/0 4854
>>
/PageWidthList <<
/0 595.276
>>
>>
>>
/Resources <<
/ExtGState <<
/GS0 42 0 R
/GS1 85 0 R
/GS2 86 0 R
/GS3 87 0 R
>>
/Font <<
/C0_0 88 0 R
/C0_1 89 0 R
/C0_2 90 0 R
/C0_3 91 0 R
/C0_4 92 0 R
/C2_0 93 0 R
/C2_1 94 0 R
/C2_10 95 0 R
/C2_11 96 0 R
/C2_12 97 0 R
/C2_13 98 0 R
/C2_14 99 0 R
/C2_15 100 0 R
/C2_16 101 0 R
/C2_17 102 0 R
/C2_18 103 0 R
/C2_19 104 0 R
/C2_2 105 0 R
/C2_20 106 0 R
/C2_21 107 0 R
/C2_3 108 0 R
/C2_4 109 0 R
/C2_5 110 0 R
/C2_6 111 0 R
/C2_7 112 0 R
/C2_8 113 0 R
/C2_9 114 0 R
/T1_0 47 0 R
/T1_1 48 0 R
/T1_10 115 0 R
/T1_11 116 0 R
/T1_12 117 0 R
/T1_13 118 0 R
/T1_14 119 0 R
/T1_15 120 0 R
/T1_16 121 0 R
/T1_17 122 0 R
/T1_18 123 0 R
/T1_19 124 0 R
/T1_2 53 0 R
/T1_20 125 0 R
/T1_21 126 0 R
/T1_22 49 0 R
/T1_23 55 0 R
/T1_3 54 0 R
/T1_4 127 0 R
/T1_5 128 0 R
/T1_6 129 0 R
/T1_7 130 0 R
/T1_8 131 0 R
/T1_9 132 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Properties <<
/MC0 133 0 R
/MC1 134 0 R
/MC10 135 0 R
/MC11 136 0 R
/MC12 137 0 R
/MC13 138 0 R
/MC14 139 0 R
/MC15 140 0 R
/MC16 141 0 R
/MC2 142 0 R
/MC3 143 0 R
/MC4 144 0 R
/MC5 145 0 R
/MC6 146 0 R
/MC7 147 0 R
/MC8 148 0 R
/MC9 149 0 R
>>
/XObject <<
/Fm0 150 0 R
/Fm1 151 0 R
/Fm2 63 0 R
/Im0 152 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
13 0 obj
<<
/Annots [153 0 R 154 0 R 155 0 R 156 0 R 157 0 R 158 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 159 0 R
/CropBox [0.0 0.0 595.276 793.701]
/LastModified (D:20211006090316-07'00')
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/PieceInfo <<
/InDesign <<
/DocumentID
/LastModified
/NumberofPages 1
/OriginalDocumentID
/PageUIDList <<
/0 15319
>>
/PageWidthList <<
/0 595.276
>>
>>
>>
/Resources <<
/ExtGState <<
/GS0 42 0 R
/GS1 160 0 R
/GS2 161 0 R
>>
/Font <<
/T1_0 47 0 R
/T1_1 48 0 R
/T1_2 53 0 R
/T1_3 49 0 R
/T1_4 55 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/XObject <<
/Fm0 80 0 R
/Fm1 81 0 R
/Im0 162 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
14 0 obj
<<
/Annots [163 0 R 164 0 R 165 0 R 166 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 167 0 R
/CropBox [0.0 0.0 595.276 793.701]
/LastModified (D:20211006090316-07'00')
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/PieceInfo <<
/InDesign <<
/DocumentID
/LastModified
/NumberofPages 1
/OriginalDocumentID
/PageUIDList <<
/0 15357
>>
/PageWidthList <<
/0 595.276
>>
>>
>>
/Resources <<
/ExtGState <<
/GS0 42 0 R
/GS1 168 0 R
/GS2 169 0 R
/GS3 170 0 R
/GS4 171 0 R
>>
/Font <<
/T1_0 47 0 R
/T1_1 48 0 R
/T1_2 53 0 R
/T1_3 49 0 R
/T1_4 172 0 R
/T1_5 55 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/XObject <<
/Fm0 173 0 R
/Fm1 151 0 R
/Im0 174 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
15 0 obj
<<
/Annots [175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 182 0 R
/CropBox [0.0 0.0 595.276 793.701]
/LastModified (D:20211006090316-07'00')
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/PieceInfo <<
/InDesign <<
/DocumentID
/LastModified
/NumberofPages 1
/OriginalDocumentID
/PageUIDList <<
/0 16082
>>
/PageWidthList <<
/0 595.276
>>
>>
>>
/Resources <<
/ExtGState <<
/GS0 42 0 R
/GS1 183 0 R
/GS2 184 0 R
/GS3 185 0 R
>>
/Font <<
/C2_0 186 0 R
/C2_1 187 0 R
/C2_2 188 0 R
/C2_3 189 0 R
/T1_0 47 0 R
/T1_1 48 0 R
/T1_2 53 0 R
/T1_3 190 0 R
/T1_4 191 0 R
/T1_5 49 0 R
/T1_6 55 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Properties <<
/MC0 192 0 R
/MC1 193 0 R
>>
/XObject <<
/Fm0 80 0 R
/Fm1 81 0 R
/Im0 194 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
16 0 obj
<<
/Annots [195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R 204 0 R
205 0 R 206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R 212 0 R 213 0 R 214 0 R
215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R 222 0 R 223 0 R 224 0 R
225 0 R 226 0 R 227 0 R 228 0 R 229 0 R 230 0 R 231 0 R]
/ArtBox [0.0 0.0 595.276 793.701]
/BleedBox [0.0 0.0 595.276 793.701]
/Contents 232 0 R
/CropBox [0.0 0.0 595.276 793.701]
/LastModified (D:20211006090316-07'00')
/MediaBox [0.0 0.0 595.276 793.701]
/Parent 5 0 R
/PieceInfo <<
/InDesign <<
/DocumentID
/LastModified
/NumberofPages 1
/OriginalDocumentID
/PageUIDList <<
/0 16152
>>
/PageWidthList <<
/0 595.276
>>
>>
>>
/Resources <<
/ExtGState <<
/GS0 42 0 R
/GS1 233 0 R
/GS2 234 0 R
>>
/Font <<
/T1_0 47 0 R
/T1_1 48 0 R
/T1_2 53 0 R
/T1_3 51 0 R
/T1_4 49 0 R
/T1_5 172 0 R
/T1_6 55 0 R
>>
/ProcSet [/PDF /Text]
/XObject <<
/Fm0 173 0 R
/Fm1 151 0 R
>>
>>
/Rotate 0
/TrimBox [0.0 0.0 595.276 793.701]
/Type /Page
>>
endobj
17 0 obj
<<
/D (d0c3b2c1-627d-465d-a867-fdc26b767a67.indd:Bookmark 1:2106)
/S /GoTo
>>
endobj
18 0 obj
<<
/A 235 0 R
/Next 236 0 R
/Parent 8 0 R
/Title
>>
endobj
19 0 obj
<<
/A 237 0 R
/Parent 8 0 R
/Prev 238 0 R
/Title
>>
endobj
20 0 obj
<<
/Length 1704
/Filter /FlateDecode
>>
stream
xX[sV;}kv&Nf0y-&$B`vyA6J@"Lo={.bb!9s3( U-*,p|uQ6ʟ˧eu.Wxs$/%Sa/zxSCFZqWvwW
Y4!ݗ_O|;
vGgћڐ;mH3l7;37`:oT 9sQh8iF&2t`;;07l:>N"
LǤyL*(*D|ש>X#+<ڴ6Ѓ07w
zBˍv["[ufqNTUE5oݝ
Ѫ5"7r| WJ̳03wŔAٷ,Ax}v7j[|ZN 3^)P
=ܢZ֖wHV.|r/~̤YK,;~$)Z<
=BoCY9$DQ5*ϜL08̾լtrޢxbo/xauRfKc'?%i;iN'KWp&b