Z-band alternatively spliced PDZ motif protein (ZASP) is the major o-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils

Man Ching Leung; Paul G. Hitchen; Douglas G. Ward; Andrew E. Messer; Steven B. Marston

doi:10.1074/jbc.M112.410316

Z-band alternatively spliced PDZ motif protein (ZASP) is the major o-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils

Man Ching Leung
, Paul G. Hitchen
, Douglas G. Ward
, Andrew E. Messer
, Steven B. Marston^*

^*Corresponding author for this work

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background: We studied O-GlcNAc-modified protein in sarcomeric proteins of human heart. Results: ZASP (Z-band alternatively spliced PDZ motif protein) accounts for 50-80% of O-GlcNAcylated protein. Conclusion: ZASP is the major O-GlcNAc-substituted protein in human heart muscle, and its levels increase in pathological muscle. Significance: Modulation of O-GlcNAcylation in ZASP may have a role in mechanotransduction in the heart.

Original language	English
Pages (from-to)	4891-4898
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.410316
Publication status	Published - 15 Feb 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Z-band alternatively spliced PDZ motif protein (ZASP) is the major o-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils",

abstract = "Background: We studied O-GlcNAc-modified protein in sarcomeric proteins of human heart. Results: ZASP (Z-band alternatively spliced PDZ motif protein) accounts for 50-80\% of O-GlcNAcylated protein. Conclusion: ZASP is the major O-GlcNAc-substituted protein in human heart muscle, and its levels increase in pathological muscle. Significance: Modulation of O-GlcNAcylation in ZASP may have a role in mechanotransduction in the heart.",

author = "Leung, \{Man Ching\} and Hitchen, \{Paul G.\} and Ward, \{Douglas G.\} and Messer, \{Andrew E.\} and Marston, \{Steven B.\}",

year = "2013",

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T1 - Z-band alternatively spliced PDZ motif protein (ZASP) is the major o-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils

AU - Leung, Man Ching

AU - Hitchen, Paul G.

AU - Ward, Douglas G.

AU - Messer, Andrew E.

AU - Marston, Steven B.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: We studied O-GlcNAc-modified protein in sarcomeric proteins of human heart. Results: ZASP (Z-band alternatively spliced PDZ motif protein) accounts for 50-80% of O-GlcNAcylated protein. Conclusion: ZASP is the major O-GlcNAc-substituted protein in human heart muscle, and its levels increase in pathological muscle. Significance: Modulation of O-GlcNAcylation in ZASP may have a role in mechanotransduction in the heart.

AB - Background: We studied O-GlcNAc-modified protein in sarcomeric proteins of human heart. Results: ZASP (Z-band alternatively spliced PDZ motif protein) accounts for 50-80% of O-GlcNAcylated protein. Conclusion: ZASP is the major O-GlcNAc-substituted protein in human heart muscle, and its levels increase in pathological muscle. Significance: Modulation of O-GlcNAcylation in ZASP may have a role in mechanotransduction in the heart.

UR - https://www.scopus.com/pages/publications/84874096862

U2 - 10.1074/jbc.M112.410316

DO - 10.1074/jbc.M112.410316

M3 - Article

C2 - 23271734

AN - SCOPUS:84874096862

SN - 0021-9258

VL - 288

SP - 4891

EP - 4898

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

Z-band alternatively spliced PDZ motif protein (ZASP) is the major o-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils

Abstract

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