Z-band alternatively spliced PDZ motif protein (ZASP) is the major o-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils

Man Ching Leung, Paul G. Hitchen, Douglas G. Ward, Andrew E. Messer, Steven B. Marston

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background: We studied O-GlcNAc-modified protein in sarcomeric proteins of human heart. Results: ZASP (Z-band alternatively spliced PDZ motif protein) accounts for 50-80% of O-GlcNAcylated protein. Conclusion: ZASP is the major O-GlcNAc-substituted protein in human heart muscle, and its levels increase in pathological muscle. Significance: Modulation of O-GlcNAcylation in ZASP may have a role in mechanotransduction in the heart.

Original languageEnglish
Pages (from-to)4891-4898
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
Publication statusPublished - 15 Feb 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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