YieJ (CbrC) mediates CreBC-dependent Colicin E2 Tolerance in Escherichia coli.

SJ Cariss, Chrystala Constantinidou, Mala Patel, Y Takebayashi, Jonathan Hobman, Charles Penn, MB Avison

Research output: Contribution to journalArticle

10 Citations (Scopus)


Colicin E2 tolerant (known as Cet2) Escherichia coli K-12 mutants over-produce an inner membrane protein, CreD, which is believed to cause the Cet2 phenotype. Here we show that over-production of CreD in a Cet2 strain results from hyper-activation of the CreBC two-component regulator, but CreD over-production is not responsible for the Cet2 phenotype. Through microarray analysis, gene knockout and over-expression studies, we show that over-expression of another CreBC-regulated gene, yieJ (also known as cbrC) causes the Cet2 phenotype.
Original languageEnglish
Pages (from-to)3329-36
Number of pages8
JournalJournal of Bacteriology
Publication statusPublished - 23 Apr 2010


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