Will telomere erosion lead to a loss of T-cell memory?

AN Akbar, PCL Beverley, Michael Salmon

    Research output: Contribution to journalReview article

    96 Citations (Scopus)

    Abstract

    Evidence is accumulating that elderly individuals are more susceptible to infection with organisms to which they were previously immune. This indicates that there might be a limit to the persistence of immune memory. This fact is particularly disturbing because the average life expectancy of humans has almost doubled in the past 200 years and is still increasing. We discuss mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases.
    Original languageEnglish
    Pages (from-to)737-743
    Number of pages7
    JournalNature Reviews Immunology
    Volume4
    Issue number9
    DOIs
    Publication statusPublished - 1 Sep 2004

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