Which biopsychosocial factors are associated with the development of chronic musculoskeletal pain?: protocol for an umbrella review of systematic reviews

Michael Dunn; Alison B Rushton; Jai Mistry; Andrew Soundy; Nicola R Heneghan

doi:10.1136/bmjopen-2021-053941

Which biopsychosocial factors are associated with the development of chronic musculoskeletal pain? protocol for an umbrella review of systematic reviews

Michael Dunn, Alison B Rushton, Jai Mistry, Andrew Soundy, Nicola R Heneghan

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Abstract

Introduction: Recent systematic reviews have identified many biopsychosocial factors associated with the development of chronic musculoskeletal pain (CMP). Despite often being specific to a particular musculoskeletal condition, findings are similar across systematic reviews. Research is needed to aggregate these findings to identify consistent factors across musculoskeletal disorders that are associated with the development of CMP. The objective of this study is to provide a meta-level synthesis of all biopsychosocial factors associated with the development of CMP.

Methods and analysis: An umbrella review and meta-level narrative synthesis±meta-analysis has been designed informed by Joanna Briggs Institute and Cochrane guidance. This protocol is reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-P. Sources will include Ovid Medline, Embase, Web of Science Core Collection, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, PsycINFO, CINAHL, PEDro, PROSPERO, Google Scholar and grey literature. Inclusion criteria: any systematic review which investigates biopsychosocial factors which may be associated with the development of CMP through prospective longitudinal methods. The outcome is musculoskeletal pain lasting beyond 3 months. Two independent reviewers will be involved in all stages; screening, selection, data extraction and risk of bias evaluation using the Assessing the Methodological Quality of Systematic Reviews-2 guidelines. A meta-level narrative synthesis will be conducted based on (a) factors associated with development of CMP, (b) the range of musculoskeletal disorders for which the same/similar findings have been established and (c) the quality of studies informing these findings. Where possible, meta-analysis will be performed. The Grading of Recommendations, Assessment, Development and Evaluation guidelines will be followed to determine the level of evidence for each biopsychosocial factor.

Ethics and dissemination: This umbrella review does not require ethical approval. Findings will be presented at conferences and published in a peer reviewed journal.

PROSPERO registration number: CRD42020193081.

Original language	English
Article number	e053941
Journal	BMJ open
Volume	11
Issue number	10
DOIs	https://doi.org/10.1136/bmjopen-2021-053941
Publication status	Published - 11 Oct 2021

Bibliographical note

Publisher Copyright:
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords

epidemiology
musculoskeletal disorders
pain management

ASJC Scopus subject areas

Medicine(all)

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Cite this

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title = "Which biopsychosocial factors are associated with the development of chronic musculoskeletal pain?: protocol for an umbrella review of systematic reviews",

abstract = "Introduction: Recent systematic reviews have identified many biopsychosocial factors associated with the development of chronic musculoskeletal pain (CMP). Despite often being specific to a particular musculoskeletal condition, findings are similar across systematic reviews. Research is needed to aggregate these findings to identify consistent factors across musculoskeletal disorders that are associated with the development of CMP. The objective of this study is to provide a meta-level synthesis of all biopsychosocial factors associated with the development of CMP.Methods and analysis: An umbrella review and meta-level narrative synthesis±meta-analysis has been designed informed by Joanna Briggs Institute and Cochrane guidance. This protocol is reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-P. Sources will include Ovid Medline, Embase, Web of Science Core Collection, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, PsycINFO, CINAHL, PEDro, PROSPERO, Google Scholar and grey literature. Inclusion criteria: any systematic review which investigates biopsychosocial factors which may be associated with the development of CMP through prospective longitudinal methods. The outcome is musculoskeletal pain lasting beyond 3 months. Two independent reviewers will be involved in all stages; screening, selection, data extraction and risk of bias evaluation using the Assessing the Methodological Quality of Systematic Reviews-2 guidelines. A meta-level narrative synthesis will be conducted based on (a) factors associated with development of CMP, (b) the range of musculoskeletal disorders for which the same/similar findings have been established and (c) the quality of studies informing these findings. Where possible, meta-analysis will be performed. The Grading of Recommendations, Assessment, Development and Evaluation guidelines will be followed to determine the level of evidence for each biopsychosocial factor.Ethics and dissemination: This umbrella review does not require ethical approval. Findings will be presented at conferences and published in a peer reviewed journal.PROSPERO registration number: CRD42020193081.",

keywords = "epidemiology, musculoskeletal disorders, pain management",

author = "Michael Dunn and Rushton, {Alison B} and Jai Mistry and Andrew Soundy and Heneghan, {Nicola R}",

note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

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