Abstract
It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of these processes has revealed profound similarities in the specific molecules involved in persistence of inflammation and in both the primary induction of neoplastic processes and in specification of the preferred anatomic sites of metastatic spread. The therapeutic importance of these findings is underscored by the remarkable success in the treatment of autoimmune pathology using medications initially developed for use in oncology and this arena is one of considerable therapeutic promise for rheumatologists.
| Original language | English |
|---|---|
| Journal | Arthritis Research & Therapy |
| Volume | 15 |
| Issue number | 114 |
| DOIs | |
| Publication status | Published - 1 May 2013 |
Keywords
- Autoimmune Diseases
- Humans
- Inflammation
- Neoplasms
- Rheumatology
- Translational Medical Research
Access to Document
- Sherlock et al ar4203
Checked for eligibility: 22/12/2015. Authors of Research articles, Commentaries, Editorials, Letters, Meeting reports and Reviews articles published in Arthritis Research & Therapy are the copyright holders of their articles and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the article, according to the BioMed Central copyright and license agreement.