TY - JOUR
T1 - Vital exhaustion and cardiovascular disease: are circulating fibrinogen and D-dimer levels a plausible link?
AU - Bennett, Philip
AU - Lane, Deirdre
AU - Lip, Gregory
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Vital exhaustion has been implicated in the development and progression of cardiovascular disease. In addition, elevated levels of fibrinogen and D-dimer have been associated with an increased risk of cardiovascular disease. Some studies have suggested that fibrinogen and D-dimer are associated with acute, chronic, and perceived stress. In this issue, Kudielka et al examine the relationship between circulating fibrinogen and D-dimer levels and vital exhaustion in a cross-sectional study of middle-aged teachers in Germany, to examine the plausible link between chronic stress and the development of cardiovascular disease. This commentary discusses the limited available evidence of the mechanisms responsible for the association between vital exhaustion and the development of cardiovascular disease and highlights the limitations of previous research and discusses future directions.
AB - Vital exhaustion has been implicated in the development and progression of cardiovascular disease. In addition, elevated levels of fibrinogen and D-dimer have been associated with an increased risk of cardiovascular disease. Some studies have suggested that fibrinogen and D-dimer are associated with acute, chronic, and perceived stress. In this issue, Kudielka et al examine the relationship between circulating fibrinogen and D-dimer levels and vital exhaustion in a cross-sectional study of middle-aged teachers in Germany, to examine the plausible link between chronic stress and the development of cardiovascular disease. This commentary discusses the limited available evidence of the mechanisms responsible for the association between vital exhaustion and the development of cardiovascular disease and highlights the limitations of previous research and discusses future directions.
U2 - 10.1080/10253890701833029
DO - 10.1080/10253890701833029
M3 - Article
C2 - 18574785
SN - 1476-5527
VL - 11
SP - 247
EP - 249
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
IS - 4
ER -