Visualizing muscle cell migration in situ

B Knight, C Laukaitis, N Akhtar, N A Hotchin, M Edlund, A R Horwitz

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


Cell migration has been studied extensively by manipulating and observing cells bathed in putative chemotactic or chemokinetic agents on planar substrates. This environment differs from that in vivo and, consequently, the cells can behave abnormally. Embryo slices provide an optically accessible system for studying cellular navigation pathways during development. We extended this system to observe the migration of muscle precursors from the somite into the forelimb, their cellular morphology, and the localization of green fluorescent protein (GFP)-tagged adhesion-related molecules under normal and perturbed conditions.
Original languageEnglish
Pages (from-to)576-85
Number of pages10
JournalCurrent Biology
Issue number10
Publication statusPublished - 2000


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