Visual deterioration in patients with photoreceptor loss after retinal reattachment surgery

Sana Rasool, Megha Kaushik, Rishika Chaudhary, Karen Blachford, Martin Berry, Robert A. H. Scott, Ann Logan, Richard J. Blanch

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose

Assess the relationship between photoreceptor degeneration and visual function after retinal reattachment surgery (RRS) in a prospective cohort.
Methods

Patients with rhegmatogenous retinal detachment (RRD) were reviewed before and 6 months after vitreoretinal surgery. Optical coherence tomographical thickness of the outer nuclear layer (ONL), outer retinal segment (ORS), retinal pigmented epithelium to ellipsoid zone (RPE-EZ) and external limiting membrane to EZ (ELM-EZ) were recorded 6 months post-operatively. These were compared to best corrected visual acuity (BCVA) and retinal sensitivity (Humphrey visual field).
Results

Thirteen macula-off and 8 macula-on RRD patients were included. The mean ONL thickness was higher after macula-on RRD compared to macula-off RRD (97.70 ± 3.62 μm vs. 73.10 ± 4.98 μm). In all RRD eyes, every 1 μm decrease in ONL thickness correlated with a 0.052 dB decrease and in retinal sensitivity and every 1 μm decrease in ORS thickness was associated with a 0.062 dB reduction in retinal sensitivity. ORS, ELM-EZ and RPE-EZ thickness did not correlate with BCVA post-RRS.
Conclusion

There was greater ONL and ORS thinning following macula-off compared to macula-on RRD. Correlations between ONL and ORS thinning with decreased retinal sensitivity may be explained by RRD-induced photoreceptor death.
Original languageEnglish
Pages (from-to)2141-2147
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume260
Issue number7
DOIs
Publication statusPublished - 26 Jan 2022

Keywords

  • Retinal detachment
  • Photoreceptors
  • Apoptosis
  • Visual field
  • Visual activity
  • OCT

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