Abstract
As opportunistic pathogens, viruses have evolved many elegant strategies to manipulate host cells for infectious entry and replication. Viral apoptotic mimicry, defined by the exposure of phosphatidylserine - a marker for apoptosis - on the pathogen surface, is emerging as a common theme used by enveloped viruses to promote infection. Focusing on the four best described examples (vaccinia virus, dengue virus, Ebola virus and pseudotyped lentivirus), we summarize our current understanding of apoptotic mimicry as a mechanism for virus entry, binding and immune evasion. We also describe recent examples of non-enveloped viruses that use this mimicry strategy, and discuss future directions and how viral apoptotic mimicry could be targeted therapeutically.
| Original language | English |
|---|---|
| Pages (from-to) | 461-469 |
| Number of pages | 9 |
| Journal | Nature Reviews Microbiology |
| Volume | 13 |
| Issue number | 8 |
| Early online date | 8 Jun 2015 |
| DOIs | |
| Publication status | Published - Aug 2015 |
ASJC Scopus subject areas
- Microbiology
- Immunology and Microbiology(all)
- Infectious Diseases
