Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study

Jeanette Trickey; Ilfita Sahbudin; Mads Ammitzbøll-Danielsen; Irene Azzolin; Carina Borst; Alessandra Bortoluzzi; George Aw Bruyn; Philippe Carron; Coziana Ciurtin; Georgios Filippou; Jacek Fliciński; Daniela Fodor; Hélène Gouze; Marwin Gutierrez; Hilde Berner Hammer; Ellen-Margrethe Hauge; Annamaria Iagnocco; Kei Ikeda; Rositsa Karalilova; Helen Isobel Keen; Marion Kortekaas; Giuliana La Paglia; Gustavo Leon; Peter Mandl; Mihaela Maruseac; Marcin Milchert; Mohamed Atia Mortada; Esperanza Naredo; Sarah Ohrndorf; Carlos Pineda; Mads Nyhuus Bendix Rasch; Cristina Reátegui-Sokolova; Garifallia Sakellariou; Teodora Serban; Cesar A Sifuentes-Cantú; Maria S Stoenoiu; Takeshi Suzuki; Lene Terslev; Ilaria Tinazzi; Florentin Ananu Vreju; Ruth Wittoek; Maria-Antonietta D'Agostino; Andrew Filer

doi:10.1136/annrheumdis-2021-219931

Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study

Jeanette Trickey, Ilfita Sahbudin, Mads Ammitzbøll-Danielsen, Irene Azzolin, Carina Borst, Alessandra Bortoluzzi, George Aw Bruyn, Philippe Carron, Coziana Ciurtin, Georgios Filippou, Jacek Fliciński, Daniela Fodor, Hélène Gouze, Marwin Gutierrez, Hilde Berner Hammer, Ellen-Margrethe Hauge, Annamaria Iagnocco, Kei Ikeda, Rositsa Karalilova, Helen Isobel KeenMarion Kortekaas, Giuliana La Paglia, Gustavo Leon, Peter Mandl, Mihaela Maruseac, Marcin Milchert, Mohamed Atia Mortada, Esperanza Naredo, Sarah Ohrndorf, Carlos Pineda, Mads Nyhuus Bendix Rasch, Cristina Reátegui-Sokolova, Garifallia Sakellariou, Teodora Serban, Cesar A Sifuentes-Cantú, Maria S Stoenoiu, Takeshi Suzuki, Lene Terslev, Ilaria Tinazzi, Florentin Ananu Vreju, Ruth Wittoek, Maria-Antonietta D'Agostino, Andrew Filer

Inflammation and Ageing

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Abstract

OBJECTIVES: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range.

METHODS: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort.

RESULTS: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups.

CONCLUSIONS: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.

Original language	English
Journal	Annals of the Rheumatic Diseases
Early online date	18 Aug 2021
DOIs	https://doi.org/10.1136/annrheumdis-2021-219931
Publication status	E-pub ahead of print - 18 Aug 2021

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Trickey, J., Sahbudin, I., Ammitzbøll-Danielsen, M., Azzolin, I., Borst, C., Bortoluzzi, A., Bruyn, G. A., Carron, P., Ciurtin, C., Filippou, G., Fliciński, J., Fodor, D., Gouze, H., Gutierrez, M., Hammer, H. B., Hauge, E-M., Iagnocco, A., Ikeda, K., Karalilova, R., ... Filer, A. (2021). Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study. Annals of the Rheumatic Diseases. Advance online publication. https://doi.org/10.1136/annrheumdis-2021-219931

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title = "Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study",

abstract = "OBJECTIVES: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range.METHODS: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort.RESULTS: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups.CONCLUSIONS: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.",

author = "Jeanette Trickey and Ilfita Sahbudin and Mads Ammitzb{\o}ll-Danielsen and Irene Azzolin and Carina Borst and Alessandra Bortoluzzi and Bruyn, {George Aw} and Philippe Carron and Coziana Ciurtin and Georgios Filippou and Jacek Flici{\'n}ski and Daniela Fodor and H{\'e}l{\`e}ne Gouze and Marwin Gutierrez and Hammer, {Hilde Berner} and Ellen-Margrethe Hauge and Annamaria Iagnocco and Kei Ikeda and Rositsa Karalilova and Keen, {Helen Isobel} and Marion Kortekaas and {La Paglia}, Giuliana and Gustavo Leon and Peter Mandl and Mihaela Maruseac and Marcin Milchert and Mortada, {Mohamed Atia} and Esperanza Naredo and Sarah Ohrndorf and Carlos Pineda and Rasch, {Mads Nyhuus Bendix} and Cristina Re{\'a}tegui-Sokolova and Garifallia Sakellariou and Teodora Serban and Sifuentes-Cant{\'u}, {Cesar A} and Stoenoiu, {Maria S} and Takeshi Suzuki and Lene Terslev and Ilaria Tinazzi and Vreju, {Florentin Ananu} and Ruth Wittoek and Maria-Antonietta D'Agostino and Andrew Filer",

note = "{\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.",

year = "2021",

month = aug,

day = "18",

doi = "10.1136/annrheumdis-2021-219931",

language = "English",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

publisher = "BMJ Publishing Group",

}

Trickey, J, Sahbudin, I, Ammitzbøll-Danielsen, M, Azzolin, I, Borst, C, Bortoluzzi, A, Bruyn, GA, Carron, P, Ciurtin, C, Filippou, G, Fliciński, J, Fodor, D, Gouze, H, Gutierrez, M, Hammer, HB, Hauge, E-M, Iagnocco, A, Ikeda, K, Karalilova, R, Keen, HI, Kortekaas, M, La Paglia, G, Leon, G, Mandl, P, Maruseac, M, Milchert, M, Mortada, MA, Naredo, E, Ohrndorf, S, Pineda, C, Rasch, MNB, Reátegui-Sokolova, C, Sakellariou, G, Serban, T, Sifuentes-Cantú, CA, Stoenoiu, MS, Suzuki, T, Terslev, L, Tinazzi, I, Vreju, FA, Wittoek, R, D'Agostino, M-A & Filer, A 2021, 'Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study', Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2021-219931

TY - JOUR

T1 - Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range

T2 - OMERACT ultrasound minimal disease study

AU - Trickey, Jeanette

AU - Sahbudin, Ilfita

AU - Ammitzbøll-Danielsen, Mads

AU - Azzolin, Irene

AU - Borst, Carina

AU - Bortoluzzi, Alessandra

AU - Bruyn, George Aw

AU - Carron, Philippe

AU - Ciurtin, Coziana

AU - Filippou, Georgios

AU - Fliciński, Jacek

AU - Fodor, Daniela

AU - Gouze, Hélène

AU - Gutierrez, Marwin

AU - Hammer, Hilde Berner

AU - Hauge, Ellen-Margrethe

AU - Iagnocco, Annamaria

AU - Ikeda, Kei

AU - Karalilova, Rositsa

AU - Keen, Helen Isobel

AU - Kortekaas, Marion

AU - La Paglia, Giuliana

AU - Leon, Gustavo

AU - Mandl, Peter

AU - Maruseac, Mihaela

AU - Milchert, Marcin

AU - Mortada, Mohamed Atia

AU - Naredo, Esperanza

AU - Ohrndorf, Sarah

AU - Pineda, Carlos

AU - Rasch, Mads Nyhuus Bendix

AU - Reátegui-Sokolova, Cristina

AU - Sakellariou, Garifallia

AU - Serban, Teodora

AU - Sifuentes-Cantú, Cesar A

AU - Stoenoiu, Maria S

AU - Suzuki, Takeshi

AU - Terslev, Lene

AU - Tinazzi, Ilaria

AU - Vreju, Florentin Ananu

AU - Wittoek, Ruth

AU - D'Agostino, Maria-Antonietta

AU - Filer, Andrew

PY - 2021/8/18

Y1 - 2021/8/18

N2 - OBJECTIVES: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range.METHODS: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort.RESULTS: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups.CONCLUSIONS: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.

AB - OBJECTIVES: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range.METHODS: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort.RESULTS: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups.CONCLUSIONS: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.

U2 - 10.1136/annrheumdis-2021-219931

DO - 10.1136/annrheumdis-2021-219931

M3 - Article

C2 - 34407928

SN - 0003-4967

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

ER -

Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study

Abstract

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