Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles

Caterina Minelli, Magdalena Wywijas, Dorota Bartczak, Susana Cuello-Nuñez, Heidi Goenaga Infante, Jerome Deumer, Christian Gollwitzer, Michael Krumrey, Karen E Murphy, Monique E Johnson, Antonio R Montoro Bustos, Ingo H Strenge, Bertrand Faure, Peter Høghøj, Vivian Tong, Loïc Burr, Karin Norling, Fredrik Höök, Matthias Roesslein, Jovana KocicLyndsey Hendriks, Vikram Kestens, Yannic Ramaye, Maria C Contreras Lopez, Guy Auclair, Dora Mehn, Douglas Gilliland, Annegret Potthoff, Kathrin Oelschlägel, Jutta Tentschert, Harald Jungnickel, Benjamin C Krause, Yves U Hachenberger, Philipp Reichardt, Andreas Luch, Thomas E Whittaker, Molly M Stevens, Shalini Gupta, Akash Singh, Fang-Hsin Lin, Yi-Hung Liu, Anna Luisa Costa, Carlo Baldisserri, Rid Jawad, Samir E L Andaloussi, Margaret N Holme, Tae Geol Lee, Minjeong Kwak, Jaeseok Kim, Johanna Ziebel, Cedric Guignard, Sebastien Cambier, Servane Contal, Arno C Gutleb, Jan Kuba Tatarkiewicz, Bartłomiej J Jankiewicz, Bartosz Bartosewicz, Xiaochun Wu, Jeffrey A Fagan, Elisabeth Elje, Elise Rundén-Pran, Maria Dusinska, Inder Preet Kaur, David Price, Ian Nesbitt, Sarah O Reilly, Ruud J B Peters, Guillaume Bucher, Dennis Coleman, Angela J Harrison, Antoine Ghanem, Anne Gering, Eileen McCarron, Niamh Fitzgerald, Geert Cornelis, Jani Tuoriniemi, Midori Sakai, Hidehisa Tsuchida, Ciarán Maguire, Adriele Prina-Mello, Alan J Lawlor, Jessica Adams, Carolin L Schultz, Doru Constantin, Nguyen Thi Kim Thanh, Le Duc Tung, Luca Panariello, Spyridon Damilos, Asterios Gavriilidis, Iseult Lynch, Benjamin Fryer, Ana Carrazco Quevedo, Emily Guggenheim, Sophie Briffa, Eugenia Valsami-Jones, Yuxiong Huang, Arturo A Keller, Virva-Tuuli Kinnunen, Siiri Perämäki, Zeljka Krpetic, Michael Greenwood, Alexander G Shard

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Abstract

We describe the outcome of a large international interlaboratory study of the measurement of particle number concentration of colloidal nanoparticles, project 10 of the technical working area 34, "Nanoparticle Populations" of the Versailles Project on Advanced Materials and Standards (VAMAS). A total of 50 laboratories delivered results for the number concentration of 30 nm gold colloidal nanoparticles measured using particle tracking analysis (PTA), single particle inductively coupled plasma mass spectrometry (spICP-MS), ultraviolet-visible (UV-Vis) light spectroscopy, centrifugal liquid sedimentation (CLS) and small angle X-ray scattering (SAXS). The study provides quantitative data to evaluate the repeatability of these methods and their reproducibility in the measurement of number concentration of model nanoparticle systems following a common measurement protocol. We find that the population-averaging methods of SAXS, CLS and UV-Vis have high measurement repeatability and reproducibility, with between-labs variability of 2.6%, 11% and 1.4% respectively. However, results may be significantly biased for reasons including inaccurate material properties whose values are used to compute the number concentration. Particle-counting method results are less reproducibile than population-averaging methods, with measured between-labs variability of 68% and 46% for PTA and spICP-MS respectively. This study provides the stakeholder community with important comparative data to underpin measurement reproducibility and method validation for number concentration of nanoparticles.

Original languageEnglish
Article numberd1nr07775a
Number of pages15
JournalNanoscale
Early online date9 Mar 2022
DOIs
Publication statusE-pub ahead of print - 9 Mar 2022

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