TY - JOUR
T1 - Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity
AU - Metsios, GS
AU - Stavropoulos-Kalinoglou, Antonios
AU - Sandoo, Aamer
AU - Veldhuijzen van Zanten, Joachimina
AU - Toms, TE
AU - John, H
AU - Kitas, George
PY - 2010/3/5
Y1 - 2010/3/5
N2 - Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network.
AB - Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network.
U2 - 10.2174/1874192401004020089
DO - 10.2174/1874192401004020089
M3 - Article
C2 - 20361002
SN - 1874-1924
VL - 4
SP - 89
EP - 96
JO - The Open Cardiovascular Medicine Journal
JF - The Open Cardiovascular Medicine Journal
IS - 2
ER -