Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity

GS Metsios, Antonios Stavropoulos-Kalinoglou, Aamer Sandoo, Joachimina Veldhuijzen van Zanten, TE Toms, H John, George Kitas

Research output: Contribution to journalArticle

56 Citations (Scopus)


Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network.
Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalThe Open Cardiovascular Medicine Journal
Issue number2
Publication statusPublished - 5 Mar 2010


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