Vascular adhesion protein 1 mediates binding of T cells to human hepatic endothelium

G McNab, J L Reeves, M Salmi, S Hubscher, S Jalkanen, David Adams

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)


Molecules that regulate T-cell adhesion to hepatic endothelium and thereby recirculation of T cells to the liver are poorly understood. Because the adhesion molecule vascular adhesion protein-1 (VAP-1), which mediates lymphocyte binding to lymph node endothelium, is expressed on hepatic endothelium, it could play a role in regulating T-cell recruitment to the liver. The aim of this study was to investigate the distribution of VAP-1 expression in human liver and the ability of VAP-1 to support T-cell binding to hepatic endothelium in vitro.
Original languageEnglish
Pages (from-to)522-8
Number of pages7
Issue number2
Publication statusPublished - Feb 1996


  • Cell Adhesion
  • Endothelium
  • Endothelium, Vascular
  • Graft Rejection
  • Humans
  • Immunohistochemistry
  • Liver
  • Liver Cirrhosis, Biliary
  • Liver Transplantation
  • T-Lymphocytes
  • Vascular Cell Adhesion Molecule-1


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