Variation at the GABAA receptor gene, Rho1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

EK Green; D Grozeva; V Moskvina; ML Hamshere; Ian Jones; Lisa Jones; L Forty; S Caesar; Katherine Gordon-Smith; C Fraser; E Russell; D St Clair; AH Young; N Ferrier; A Farmer; P McGuffin; PA Holmans; MJ Owen; MC O'Donovan; N Craddock

doi:10.1002/ajmg.b.31108

Variation at the GABAA receptor gene, Rho1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

EK Green
, D Grozeva
, V Moskvina
, ML Hamshere
, Ian Jones
, Lisa Jones
, L Forty
, S Caesar
, Katherine Gordon-Smith
, C Fraser
, E Russell
, D St Clair
, AH Young
, N Ferrier
, A Farmer
, P McGuffin
, PA Holmans
, MJ Owen
, MC O'Donovan
, N Craddock

Birmingham Medical School

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

Original language	English
Pages (from-to)	1347-1349
Number of pages	3
Journal	American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume	153b
Issue number	7
DOIs	https://doi.org/10.1002/ajmg.b.31108
Publication status	Published - 1 Jan 2010

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Green, EK., Grozeva, D., Moskvina, V., Hamshere, ML., Jones, I., Jones, L., Forty, L., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., St Clair, D., Young, AH., Ferrier, N., Farmer, A., McGuffin, P., Holmans, PA., Owen, MJ., O'Donovan, MC., & Craddock, N. (2010). Variation at the GABAA receptor gene, Rho1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153b(7), 1347-1349. https://doi.org/10.1002/ajmg.b.31108

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title = "Variation at the GABAA receptor gene, Rho1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder",

abstract = "We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).",

author = "EK Green and D Grozeva and V Moskvina and ML Hamshere and Ian Jones and Lisa Jones and L Forty and S Caesar and Katherine Gordon-Smith and C Fraser and E Russell and \{St Clair\}, D and AH Young and N Ferrier and A Farmer and P McGuffin and PA Holmans and MJ Owen and MC O'Donovan and N Craddock",

year = "2010",

month = jan,

day = "1",

doi = "10.1002/ajmg.b.31108",

language = "English",

volume = "153b",

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journal = "American Journal of Medical Genetics Part B: Neuropsychiatric Genetics",

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Green, EK, Grozeva, D, Moskvina, V, Hamshere, ML, Jones, I, Jones, L, Forty, L, Caesar, S, Gordon-Smith, K, Fraser, C, Russell, E, St Clair, D, Young, AH, Ferrier, N, Farmer, A, McGuffin, P, Holmans, PA, Owen, MJ, O'Donovan, MC & Craddock, N 2010, 'Variation at the GABAA receptor gene, Rho1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 153b, no. 7, pp. 1347-1349. https://doi.org/10.1002/ajmg.b.31108

TY - JOUR

T1 - Variation at the GABAA receptor gene, Rho1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

AU - Green, EK

AU - Grozeva, D

AU - Moskvina, V

AU - Hamshere, ML

AU - Jones, Ian

AU - Jones, Lisa

AU - Forty, L

AU - Caesar, S

AU - Gordon-Smith, Katherine

AU - Fraser, C

AU - Russell, E

AU - St Clair, D

AU - Young, AH

AU - Ferrier, N

AU - Farmer, A

AU - McGuffin, P

AU - Holmans, PA

AU - Owen, MJ

AU - O'Donovan, MC

AU - Craddock, N

PY - 2010/1/1

Y1 - 2010/1/1

N2 - We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

AB - We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

U2 - 10.1002/ajmg.b.31108

DO - 10.1002/ajmg.b.31108

M3 - Article

C2 - 20583128

VL - 153b

SP - 1347

EP - 1349

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

IS - 7

ER -

Variation at the GABAA receptor gene, Rho1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

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