Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography

Subhadra Srinivasan; Brian W. Pogue; Shudong Jiang; Hamid Dehghani; Keith D. Paulsen

doi:10.1117/12.478219

Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography

Subhadra Srinivasan^*, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Keith D. Paulsen

^*Corresponding author for this work

Computer Science

Research output: Contribution to journal › Conference article › peer-review

Abstract

Near Infrared diffuse optical tomography was used to measure the molar absorption spectra for deoxyhemoglobin, oxyhemoglobin and water through phantom experiments. The measured spectra compensate for any systemic errors and errors arising from model-based estimation of concentrations of these chromophores, and show reasonable agreement with existing literature values. The spectra were validated by phantom experiments to obtain the oxygen dissociation curve. Variation of the partial pressure of oxygen in solution yielded results consistent with theory with mean error of 7.6% in estimation of oxygen saturation, and accurate within 5% in estimation of hemoglobin.

Original language	English
Pages (from-to)	407-415
Number of pages	9
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4955
DOIs	https://doi.org/10.1117/12.478219
Publication status	Published - 2003
Event	PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V - San Jose, CA, United States Duration: 26 Jan 2003 → 29 Jan 2003

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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title = "Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography",

abstract = "Near Infrared diffuse optical tomography was used to measure the molar absorption spectra for deoxyhemoglobin, oxyhemoglobin and water through phantom experiments. The measured spectra compensate for any systemic errors and errors arising from model-based estimation of concentrations of these chromophores, and show reasonable agreement with existing literature values. The spectra were validated by phantom experiments to obtain the oxygen dissociation curve. Variation of the partial pressure of oxygen in solution yielded results consistent with theory with mean error of 7.6% in estimation of oxygen saturation, and accurate within 5% in estimation of hemoglobin.",

author = "Subhadra Srinivasan and Pogue, {Brian W.} and Shudong Jiang and Hamid Dehghani and Paulsen, {Keith D.}",

year = "2003",

doi = "10.1117/12.478219",

language = "English",

volume = "4955",

pages = "407--415",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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TY - JOUR

T1 - Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography

AU - Srinivasan, Subhadra

AU - Pogue, Brian W.

AU - Jiang, Shudong

AU - Dehghani, Hamid

AU - Paulsen, Keith D.

PY - 2003

Y1 - 2003

N2 - Near Infrared diffuse optical tomography was used to measure the molar absorption spectra for deoxyhemoglobin, oxyhemoglobin and water through phantom experiments. The measured spectra compensate for any systemic errors and errors arising from model-based estimation of concentrations of these chromophores, and show reasonable agreement with existing literature values. The spectra were validated by phantom experiments to obtain the oxygen dissociation curve. Variation of the partial pressure of oxygen in solution yielded results consistent with theory with mean error of 7.6% in estimation of oxygen saturation, and accurate within 5% in estimation of hemoglobin.

AB - Near Infrared diffuse optical tomography was used to measure the molar absorption spectra for deoxyhemoglobin, oxyhemoglobin and water through phantom experiments. The measured spectra compensate for any systemic errors and errors arising from model-based estimation of concentrations of these chromophores, and show reasonable agreement with existing literature values. The spectra were validated by phantom experiments to obtain the oxygen dissociation curve. Variation of the partial pressure of oxygen in solution yielded results consistent with theory with mean error of 7.6% in estimation of oxygen saturation, and accurate within 5% in estimation of hemoglobin.

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U2 - 10.1117/12.478219

DO - 10.1117/12.478219

M3 - Conference article

AN - SCOPUS:0345413460

SN - 0277-786X

VL - 4955

SP - 407

EP - 415

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V

Y2 - 26 January 2003 through 29 January 2003

ER -

Validation of hemoglobin and water molar absorption spectra in near-infrared diffuse optical tomography

Abstract

ASJC Scopus subject areas

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