Vaccine-induced cytotoxic T lymphocytes protect against retroviral challenge

A D Hislop, M F Good, L Mateo, J Gardner, M H Gatei, R C Daniel, B V Meyers, M F Lavin, A Suhrbier

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


The development of prophylactic vaccines against retroviral diseases has been impeded by the lack of obvious immune correlates for protection. Cytotoxic T-lymphocyte (CTL), CD4-lymphocyteS, chemokine and/or antibody responses have all been associated with protection against HIV and AIDS; however, effective and safe vaccination strategies remain elusive. Here we show that vaccination with a minimal ovine CTL peptide epitope identified within gp51 of the retrovirus bovine leukemia virus (BLV), consistently induced peptide-specific CTLs. Only sheep whose CTLs were also capable of recognizing retrovirus-infected cells were fully protected when challenged with BLV. This retrovirus displays limited sequence variation; thus, in the relative absence of confounding CTL escape variants, virus-specific CTLs targeting a single epitope were able to prevent the establishment of a latent retroviral infection.

Original languageEnglish
Pages (from-to)1193-6
Number of pages4
JournalNature Medicine
Issue number10
Publication statusPublished - Oct 1998


  • Animals
  • Deltaretrovirus Infections
  • Leukemia Virus, Bovine
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Sheep
  • Sheep Diseases
  • T-Lymphocytes, Cytotoxic
  • Viral Envelope Proteins
  • Viral Vaccines
  • Virus Latency


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