Using Ex Vivo Liver Organ Cultures to Measure Lymphocyte Trafficking

Benjamin G Wiggins, Zania Stamataki, Patricia F Lalor

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


Lymphocyte recruitment to different organs, and even alternate anatomical regions within the same organ, is differentially regulated. Key combinations of adhesion molecules and chemokines govern compartmentalization, and these can change depending upon the nature and duration of tissue injury. We are interested in understanding lymphocyte recruitment to the liver during human disease, and thus need models of the liver inflammatory milieu that are as representative as possible. Here we describe the use of precision cut liver slices as models of disease.

Original languageEnglish
Title of host publicationT-Cell Trafficking:
Subtitle of host publicationMethods and Protocols
EditorsGeorge Edward Rainger, Helen M. Mcgettrick
Number of pages18
ISBN (Electronic)978-1-4939-6931-9
ISBN (Print)978-1-4939-6929-6
Publication statusPublished - 28 Mar 2017

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Journal Article
  • antibody
  • human
  • inflammation
  • liver
  • lymphocyte
  • organ culture


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