Urinary neopterin in idiopathic retinal vasculitis

HE Palmer, G Giovannoni, MR Stanford, Graham Wallace, EM Graham

Research output: Contribution to journalArticle

7 Citations (Scopus)


AIMS: To determine whether urinary neopterin:creatinine (UNC) ratios relate to disease activity in idiopathic retinal vasculitis (RV). METHODS: 18 patients with RV were prospectively recruited into a year long longitudinal study. Patients collected first morning urine samples on a weekly basis and on the same day completed a diary which documented their subjective view of RV activity and any concurrent infection. They were examined in clinic on a 6-8 weekly basis and an objective assessment was made of RV disease activity. 14 healthy controls collected urine samples in the same way. RESULTS: UNC ratios were significantly higher in patients than in controls (p=0.004, Mann-Whitney U test). UNC ratios were significantly higher when, according to their diaries, the patients had a subjective flare up of RV (p=0.001, Mann-Whitney U test). Subjective increased RV activity occurred more often when the patients had a concurrent infection (p
Original languageEnglish
Pages (from-to)30-3
Number of pages4
JournalBritish Journal of Ophthalmology
Issue number1
Publication statusPublished - 1 Jan 2001


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