Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging

SD Anker, W Doehner, M Rauchhaus, R Sharma, D Francis, C Knosalla, CH Davos, M Cicoira, W Shamin, M Kemp, R Segal, KJ Osterziel, Francisco Leyva-Leon, R Hetzer, P Ponikowski, AJ Coats

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481 Citations (Scopus)

Abstract

BACKGROUND: Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). METHODS AND RESULTS: For the derivation study, 112 patients with CHF (age 59+/-12 years, peak oxygen consumption [Vo2] 17+/-7 mL/kg per minute) were recruited. In separate studies, we validated the prognostic value of UA (n=182) and investigated the relationship between MFH score and the decision to list patients for heart transplantation (n=120). In the derivation study, the best mortality predicting UA cutoff (at 12 months) was 565 micromol/L (9.50 mg/dL) (independently of age, peak Vo2, left ventricular ejection fraction, diuretic dose, sodium, creatinine, and urea; Por=565 micromol/L predicted mortality (hazard ratio, 7.14; Por=565 micromol/L, left ventricular ejection fraction
Original languageEnglish
Pages (from-to)1991-1997
Number of pages7
JournalCirculation
Volume107
Issue number15
DOIs
Publication statusPublished - 22 Apr 2003

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