Upregulation of the pro-opiomelanocortin gene in motoneurones after acrylamide administration in mice

Sharon Hughes, T Child, MG Simpson, Margaret Smith

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Immunocytochemistry was used to demonstrate the presence of beta-endorphin and alpha-MSH, and in situ hybridisation was used to study the presence of pro-opiomelanocortin (POMC) mRNA, in spinal motoneurones, up to 8 days following the administration of a single dose of acrylamide in mice. The proportions of POMC-mRNA positive neurones, beta-endorphin-immunoreactive neurones and alpha-MSH-immunoreactive neurones were significantly increased in the treated animals compared to controls. It seems likely that upregulation of the POMC gene precedes acrylamide-induced neuropathy.
Original languageEnglish
Pages (from-to)232-234
Number of pages3
JournalNeuroscience Letters
Volume357
Issue number3
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • alpha-MSH
  • acrylamide
  • spinal cord
  • beta-endorphin
  • pro-opiomelanocortin neuropeptides

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