Update in vitamin D

John S Adams, Martin Hewison

Research output: Contribution to journalArticlepeer-review

647 Citations (Scopus)


The past decade, particularly the last 18 months, witnessed a vigorous increase in interest in vitamin D from both the lay and biomedical worlds. Much of the growing interest in vitamin D is powered by new data being extracted from the National Health and Nutrition Examination Survey (NHANES). The newest statistics demonstrate that more than 90% of the pigmented populace of the United States (Blacks, Hispanics, and Asians) now suffer from vitamin D insufficiency (25-hydroxyvitamin D <30 ng/ml), with nearly three fourths of the white population in this country also being vitamin D insufficient. This represents a near doubling of the prevalence of vitamin D insufficiency seen just 10 yr ago in the same population. This review attempts to provide some explanation for: 1) the rapid decline in vitamin D status in the United States; 2) the adverse impact of vitamin D insufficiency on skeletal, infectious/inflammatory, and metabolic health in humans; and 3) the therapeutic rationale and reliable means for vigorous supplementation of our diets with vitamin D.

Original languageEnglish
Pages (from-to)471-8
Number of pages8
JournalThe Journal of clinical endocrinology and metabolism
Issue number2
Publication statusPublished - Feb 2010


  • Animals
  • Bacterial Infections
  • Bone Density
  • Calcitriol
  • Cardiovascular Diseases
  • Humans
  • Metabolic Syndrome X
  • Vitamin D
  • Vitamin D Deficiency


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