Unravelling how glucocorticoids work in rheumatoid arthritis

Rowan Hardy; Mark S. Cooper

doi:10.1136/annrheumdis-2017-212762

Unravelling how glucocorticoids work in rheumatoid arthritis

Rowan Hardy, Mark S. Cooper

Metabolism and Systems Research

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

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Abstract

Using mice with targeted deletion of the glucocorticoid receptor, a new study has examined the cell types that mediate the anti-arthritic effects of therapeutic glucocorticoids. Surprisingly, in the serum transfer-induced arthritis model, glucocorticoids target stromal cells rather than immune cells.

Original language	English
Pages (from-to)	1759-4804
Number of pages	2
Journal	Nature Reviews Rheumatology
DOIs	https://doi.org/10.1136/annrheumdis-2017-212762
Publication status	Published - 4 Sept 2018

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10.1136/annrheumdis-2017-212762Licence: None: All rights reserved

Hardy_et_al_Unravelling_how_glucocorticoids_2018
Checked for eligibility 14/09/2018 Koenen, M. et al. Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis. Ann. Rheum. Dis. https://doi.org/10.1136/annrheumdis-2017-212762 (2018).
Accepted author manuscript, 120 KBLicence: None: All rights reserved

https://www.nature.com/articles/s41584-018-0079-4Licence: None: All rights reserved

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title = "Unravelling how glucocorticoids work in rheumatoid arthritis",

abstract = "Using mice with targeted deletion of the glucocorticoid receptor, a new study has examined the cell types that mediate the anti-arthritic effects of therapeutic glucocorticoids. Surprisingly, in the serum transfer-induced arthritis model, glucocorticoids target stromal cells rather than immune cells.",

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Unravelling how glucocorticoids work in rheumatoid arthritis

Abstract

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