Unmet clinical need in autoimmune liver diseases

Jessica K. Dyson; Gwilym Webb; Gideon M. Hirschfield; Ansgar Lohse; Ulrich Beuers; Keith Lindor; David E.j. Jones

doi:10.1016/j.jhep.2014.09.010

Unmet clinical need in autoimmune liver diseases

Jessica K. Dyson, Gwilym Webb, Gideon M. Hirschfield, Ansgar Lohse, Ulrich Beuers, Keith Lindor, David E.j. Jones

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

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Abstract

Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.

Original language	English
Pages (from-to)	208-218
Number of pages	11
Journal	Journal of Hepatology
Volume	62
Issue number	1
Early online date	16 Sept 2014
DOIs	https://doi.org/10.1016/j.jhep.2014.09.010
Publication status	Published - Jan 2015

Keywords

Unmet clinical need
Autoimmune liver diseases
Primary biliary cirrhosis
Primary sclerosing cholangitis
Autoimmune hepatitis
IgG4 disease
Stratified care delivery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jhep.2014.09.010

Dyson_et_al_Unmet_Clinical_Need_Journal_Heptalogy_2015
Article subject to the terms of a Creative Commons Non-Commercial No Derivatives license. Checked September 2015
Final published version, 1.22 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

http://linkinghub.elsevier.com/retrieve/pii/S0168827814006643

The roles and control of CD4+ effector and regulatory T-cells in biliary autoimmunity
Webb, G.
Medical Research Council
8/09/14 → 7/09/17
Project: Research Councils

Cite this

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title = "Unmet clinical need in autoimmune liver diseases",

abstract = "Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.",

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author = "Dyson, {Jessica K.} and Gwilym Webb and Hirschfield, {Gideon M.} and Ansgar Lohse and Ulrich Beuers and Keith Lindor and Jones, {David E.j.}",

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AU - Webb, Gwilym

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AU - Beuers, Ulrich

AU - Lindor, Keith

AU - Jones, David E.j.

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KW - Primary biliary cirrhosis

KW - Primary sclerosing cholangitis

KW - Autoimmune hepatitis

KW - IgG4 disease

KW - Stratified care delivery

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Unmet clinical need in autoimmune liver diseases

Abstract

Keywords

UN SDGs

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Projects

The roles and control of CD4+ effector and regulatory T-cells in biliary autoimmunity

Cite this