Abstract
The transcription factor SOX9 is crucial for multiple aspects of development. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder concordant with the expression profile of SOX9 during embryogenesis. The mechanistic understanding of development has revealed roles for SOX9 in regulating cartilage extracellular matrix (ECM) production and cell proliferation, among others. More recently, it transpires that SOX9 becomes expressed and induces destructive ECM components in organ fibrosis and related disorders. Although commonly absent from the parent cell type, SOX9 is expressed in a wide range of cancers, where it regulates cell proliferation. These data have potential diagnostic, prognostic and therapeutic relevance, suggesting that disease mechanisms might result from re-expressing this developmental transcription factor in ectopic locations.
| Original language | English |
|---|---|
| Pages (from-to) | 166-174 |
| Number of pages | 9 |
| Journal | Trends in Molecular Medicine |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2011 |
Bibliographical note
Funding Information:The authors receive support from the Manchester NIHR Biomedical Research Centre. NH is a Wellcome Trust Senior Fellow in Clinical Science and receives funding from BBSRC, EPSRC and SC4SM. KPH receives funding from BBSRC. NR holds a studentship awarded to KPH by the Gerald Kerkut Trust. Robin Deller is acknowledged for his graphics.
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
