Understanding lactate sensing and signalling

Michelangelo Certo, Alba Llibre, Wheeseong Lee, Claudio Mauro*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Metabolites generated from cellular and tissue metabolism have been rediscovered in recent years as signalling molecules. They may act as cofactor of enzymes or be linked to proteins as post-translational modifiers. They also act as ligands for specific receptors, highlighting that their neglected functions have, in fact, a long standing in evolution. Lactate is one such metabolite that has been considered for long time a waste product of metabolism devoid of any biological function. However, in the past 10 years, lactate has gained much attention in several physio-pathological processes. Mechanisms of sensing and signalling have been discovered and implicated in a broad range of diseases, from cancer to inflammation and fibrosis, providing opportunities for novel therapeutic avenues. Here, we review some of the most recently discovered mechanisms of lactate sensing and signalling.
Original languageEnglish
Pages (from-to)722-735
Number of pages14
JournalTrends in Endocrinology & Metabolism
Volume33
Issue number10
Early online date20 Aug 2022
DOIs
Publication statusPublished - 1 Oct 2022

Bibliographical note

Funding Information:
This work is supported by the Medical Research Council (MRC) grant MR/T016736/1 to C.M. and by the European Commission grant H2020-MSCA-IF-2018, 841729 to A.L. Figures were created using Biorender.com .

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • acidity
  • G protein-coupled receptor
  • lactylation
  • metabolic reprogramming

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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