TY - JOUR
T1 - Understanding clinical decision-making during the COVID-19 pandemic
T2 - A cross-sectional worldwide survey
AU - Martínez-Sanz, Javier
AU - Pérez-Molina, José A.
AU - Moreno, Santiago
AU - Zamora, Javier
AU - Serrano-Villar, Sergio
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/10
Y1 - 2020/10
N2 - Background: The lack of evidence-based recommendations for therapeutic decisions during the early weeks of the COVID-19 pandemic creates a unique scenario of clinical decision making which is worth to analyze. We aim to identify the drivers of therapeutic aggressiveness during the first weeks of the COVID-19 pandemic. Methods: This cross-sectional worldwide survey (conducted April 12 to 19, 2020) was aimed at physicians who managed patients diagnosed with COVID-19. Treatment preferences were collected in five different clinical scenarios. We used multilevel mixed-effects ordered logistic regression to identify variables that were associated with the use of more aggressive therapies. Findings: The survey was completed by 852 physicians from 44 different specialties and 29 countries. The heterogeneity of therapeutic decisions increased as the clinical scenario worsened. Factors associated with aggressive therapeutic decisions were higher self-perceived expertise (high vs. null, OR 1.95, 95%CI 1.31–2.89), perceived quality of COVID-19 publications (high vs. null, OR 1.92, 95%CI 1.17–3.16), and female sex (OR 1.17, 95%CI 1.02–1.33). Conversely, Infectious Diseases specialty, Latin American and North American origin, lower confidence in the treatments chosen, and having published articles indexed in PubMed as the first-author were associated with the use of less aggressive therapies. Interpretation: Our study provides insight into the drivers of the decision-making process during a new and extreme health emergency. Different factors including the perceived expertise and quality of publications, gender, geographic origin, medical specialty and implication in medical research influenced this process. The clinical severity attenuated the physician's tolerance for uncertainty. Funding: No funding was required.
AB - Background: The lack of evidence-based recommendations for therapeutic decisions during the early weeks of the COVID-19 pandemic creates a unique scenario of clinical decision making which is worth to analyze. We aim to identify the drivers of therapeutic aggressiveness during the first weeks of the COVID-19 pandemic. Methods: This cross-sectional worldwide survey (conducted April 12 to 19, 2020) was aimed at physicians who managed patients diagnosed with COVID-19. Treatment preferences were collected in five different clinical scenarios. We used multilevel mixed-effects ordered logistic regression to identify variables that were associated with the use of more aggressive therapies. Findings: The survey was completed by 852 physicians from 44 different specialties and 29 countries. The heterogeneity of therapeutic decisions increased as the clinical scenario worsened. Factors associated with aggressive therapeutic decisions were higher self-perceived expertise (high vs. null, OR 1.95, 95%CI 1.31–2.89), perceived quality of COVID-19 publications (high vs. null, OR 1.92, 95%CI 1.17–3.16), and female sex (OR 1.17, 95%CI 1.02–1.33). Conversely, Infectious Diseases specialty, Latin American and North American origin, lower confidence in the treatments chosen, and having published articles indexed in PubMed as the first-author were associated with the use of less aggressive therapies. Interpretation: Our study provides insight into the drivers of the decision-making process during a new and extreme health emergency. Different factors including the perceived expertise and quality of publications, gender, geographic origin, medical specialty and implication in medical research influenced this process. The clinical severity attenuated the physician's tolerance for uncertainty. Funding: No funding was required.
KW - Clinical decision-making
KW - COVID-19
KW - Surveys and questionnaires
KW - Therapeutics
KW - Uncertainty
UR - http://www.scopus.com/inward/record.url?scp=85090596923&partnerID=8YFLogxK
U2 - 10.1016/j.eclinm.2020.100539
DO - 10.1016/j.eclinm.2020.100539
M3 - Article
AN - SCOPUS:85090596923
SN - 2589-5370
VL - 27
JO - EClinicalMedicine
JF - EClinicalMedicine
M1 - 100539
ER -