Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells

PWL Ho; JWM Ho; HM Tse; DHF So; DCW Yiu; HF Liu; KH Chan; MHW Kung; David Ramsden; SL Ho

doi:10.1371/journal.pone.0032810

Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells

PWL Ho, JWM Ho, HM Tse, DHF So, DCW Yiu, HF Liu, KH Chan, MHW Kung, David Ramsden, SL Ho

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Abstract

Mitochondrial uncoupling protein-4 (UCP4) protects against Complex I deficiency as induced by 1-methyl-4-phenylpyridinium (MPP+), but how UCP4 affects mitochondrial function is unclear. Here we investigated how UCP4 affects mitochondrial bioenergetics in SH-SY5Y cells. Cells stably overexpressing UCP4 exhibited higher oxygen consumption (10.1%, p

Original language	English
Pages (from-to)	e32810
Journal	PLoS ONE
Volume	7
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0032810
Publication status	Published - 1 Feb 2012

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abstract = "Mitochondrial uncoupling protein-4 (UCP4) protects against Complex I deficiency as induced by 1-methyl-4-phenylpyridinium (MPP+), but how UCP4 affects mitochondrial function is unclear. Here we investigated how UCP4 affects mitochondrial bioenergetics in SH-SY5Y cells. Cells stably overexpressing UCP4 exhibited higher oxygen consumption (10.1%, p",

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AU - Ho, JWM

AU - Tse, HM

AU - So, DHF

AU - Yiu, DCW

AU - Liu, HF

AU - Chan, KH

AU - Kung, MHW

AU - Ramsden, David

AU - Ho, SL

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AB - Mitochondrial uncoupling protein-4 (UCP4) protects against Complex I deficiency as induced by 1-methyl-4-phenylpyridinium (MPP+), but how UCP4 affects mitochondrial function is unclear. Here we investigated how UCP4 affects mitochondrial bioenergetics in SH-SY5Y cells. Cells stably overexpressing UCP4 exhibited higher oxygen consumption (10.1%, p

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Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells

Abstract

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