Uncertainties in the antibacterial mechanisms of graphene family materials

Peng Zhang; Zhiling Guo; Chunying Chen; Iseult Lynch

doi:10.1016/j.nantod.2022.101436

Uncertainties in the antibacterial mechanisms of graphene family materials

Peng Zhang, Zhiling Guo^*, Chunying Chen, Iseult Lynch

^*Corresponding author for this work

Earth and Environmental Sciences

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Abstract

The antibacterial activity of graphene family materials (GFMs) has been explored since 2010, 6 years after the discovery of graphene in 2004. It is proposed that the antibacterial activity is derived from both physical interaction and chemical reaction between GFMs and bacteria. However, whether the two mechanisms work synergistically or whether there are conditions under which one mechanism dominates remains uncertain. This opinion article highlights the uncertainties and controversies in the current understanding of antibacterial mechanisms of GFMs as well as deficiencies in methodologies and provides perspectives on future directions to move this field forward.

Original language	English
Article number	101436
Journal	Nano Today
Volume	43
Early online date	21 Feb 2022
DOIs	https://doi.org/10.1016/j.nantod.2022.101436
Publication status	Published - Apr 2022

Bibliographical note

Funding Information:
This work was supported by the EU H2020 NanoCommons (Grant Agreement No. 731032 ), EU H2020 NanoSolveIT (Grant Agreement No. 814572 ), EPSRC IAA Developing Leaders (Grant No. 1001634 ), and Major instrument project of National Natural Science Foundation of China ( 22027810 ).

Keywords

Bacteria
Computational modelling
Graphene family materials
Oxidative damage
Physical interaction

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
General Materials Science
Pharmaceutical Science

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title = "Uncertainties in the antibacterial mechanisms of graphene family materials",

abstract = "The antibacterial activity of graphene family materials (GFMs) has been explored since 2010, 6 years after the discovery of graphene in 2004. It is proposed that the antibacterial activity is derived from both physical interaction and chemical reaction between GFMs and bacteria. However, whether the two mechanisms work synergistically or whether there are conditions under which one mechanism dominates remains uncertain. This opinion article highlights the uncertainties and controversies in the current understanding of antibacterial mechanisms of GFMs as well as deficiencies in methodologies and provides perspectives on future directions to move this field forward.",

keywords = "Bacteria, Computational modelling, Graphene family materials, Oxidative damage, Physical interaction",

author = "Peng Zhang and Zhiling Guo and Chunying Chen and Iseult Lynch",

note = "Funding Information: This work was supported by the EU H2020 NanoCommons (Grant Agreement No. 731032 ), EU H2020 NanoSolveIT (Grant Agreement No. 814572 ), EPSRC IAA Developing Leaders (Grant No. 1001634 ), and Major instrument project of National Natural Science Foundation of China ( 22027810 ). ",

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AU - Zhang, Peng

AU - Guo, Zhiling

AU - Chen, Chunying

AU - Lynch, Iseult

N1 - Funding Information: This work was supported by the EU H2020 NanoCommons (Grant Agreement No. 731032 ), EU H2020 NanoSolveIT (Grant Agreement No. 814572 ), EPSRC IAA Developing Leaders (Grant No. 1001634 ), and Major instrument project of National Natural Science Foundation of China ( 22027810 ).

PY - 2022/4

Y1 - 2022/4

N2 - The antibacterial activity of graphene family materials (GFMs) has been explored since 2010, 6 years after the discovery of graphene in 2004. It is proposed that the antibacterial activity is derived from both physical interaction and chemical reaction between GFMs and bacteria. However, whether the two mechanisms work synergistically or whether there are conditions under which one mechanism dominates remains uncertain. This opinion article highlights the uncertainties and controversies in the current understanding of antibacterial mechanisms of GFMs as well as deficiencies in methodologies and provides perspectives on future directions to move this field forward.

AB - The antibacterial activity of graphene family materials (GFMs) has been explored since 2010, 6 years after the discovery of graphene in 2004. It is proposed that the antibacterial activity is derived from both physical interaction and chemical reaction between GFMs and bacteria. However, whether the two mechanisms work synergistically or whether there are conditions under which one mechanism dominates remains uncertain. This opinion article highlights the uncertainties and controversies in the current understanding of antibacterial mechanisms of GFMs as well as deficiencies in methodologies and provides perspectives on future directions to move this field forward.

KW - Bacteria

KW - Computational modelling

KW - Graphene family materials

KW - Oxidative damage

KW - Physical interaction

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DO - 10.1016/j.nantod.2022.101436

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SN - 1748-0132

VL - 43

JO - Nano Today

JF - Nano Today

M1 - 101436

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Uncertainties in the antibacterial mechanisms of graphene family materials

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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