Ultrasonic cavitation near a tissue layer

G. A. Curtiss, D. M. Leppinen, Qian Wang, John Blake

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38 Citations (Scopus)
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In this paper we examine the dynamics of an initially stable bubble due to ultrasonic forcing by an acoustic wave. A tissue layer is modelled as a density interface acted upon by surface tension to mimic membrane effects. The effect of a rigid backing to the thin tissue layer is investigated. We are interested in ultrasound contrast agent type bubbles which have immediate biomedical applications such as the delivery of drugs and the instigation of sonoporation. We use the axisymmetric boundary integral technique detailed in Curtiss et al. (J. Comput. Phys., 2013, submitted) to model the interaction between a single bubble and the tissue layer. We have identified a new peeling mechanism whereby the re-expansion of a toroidal bubble can peel away tissue from a rigid backing. We explore the problem over a large range of parameters including tissue layer depth, interfacial tension and ultrasonic forcing.
Original languageEnglish
Pages (from-to)245-272
JournalJournal of Fluid Mechanics
Early online date30 Jul 2013
Publication statusPublished - 1 Sept 2013


  • bubble dynamics
  • cavitation
  • drops and bubbles


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