Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction

E G Wilmot; M Leggate; J N Khan; T Yates; T Gorely; D H Bodicoat; K Khunti; J P A Kuijer; L J Gray; A Singh; P Clarysse; P Croisille; M A Nimmo; G P McCann; M J Davies

doi:10.1111/dme.12431

Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction

E G Wilmot, M Leggate, J N Khan, T Yates, T Gorely, D H Bodicoat, K Khunti, J P A Kuijer, L J Gray, A Singh, P Clarysse, P Croisille, M A Nimmo, G P McCann, M J Davies

Life and Environmental Sciences

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

AIM: A pilot study to phenotype young adults (< 40 years) with Type 2 diabetes mellitus.

METHODS: Twenty people with Type 2 diabetes (aged 18-40 years), 10 lean and 10 obese control subjects underwent detailed assessment, including tagged cardiac magnetic resonance imaging, inflammatory proteins, lipids, vitamin D and maximal oxygen uptake. Outcomes were compared between the group with Type 2 diabetes and the control group.

RESULTS: Mean (standard deviation) age, Type 2 diabetes duration and BMI in the group with Type 2 diabetes were 31.8 (6.6) years, 4.7 (4.0) years and 33.9 (5.8) kg/m(2) respectively. Compared with lean control subjects, those with Type 2 diabetes had more deleterious profiles of hyperlipidaemia, vitamin D deficiency, inflammation and maximal oxygen uptake relative to body mass. However, there was no difference between the group with Type 2 diabetes and the obese control group. The group with Type 2 diabetes had a higher left ventricular mass and a trend towards concentric remodelling compared with the lean control group (P = 0.002, P = 0.052) but not the obese control group (P > 0.05). Peak early diastolic strain rate was reduced in the group with Type 2 diabetes [1.51 (0.24)/s] compared with the lean control [1.97 (0.34)/s, P = 0.001] and obese control [1.78 (0.39)/s, P = 0.042] group.

CONCLUSIONS: Young adults with Type 2 diabetes and those with obesity have similar adverse cardiovascular risk profiles, higher left ventricular mass and a trend towards left ventricular concentric remodelling. In addition, those with Type 2 diabetes demonstrate diastolic dysfunction, a known risk marker for future heart failure and mortality.

Original language	English
Pages (from-to)	794-798
Number of pages	5
Journal	Diabetic Medicine
Volume	31
Issue number	7
Early online date	8 Mar 2014
DOIs	https://doi.org/10.1111/dme.12431
Publication status	Published - Jul 2014

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/dme.12431Licence: None: All rights reserved

https://onlinelibrary.wiley.com/doi/full/10.1111/dme.12431Licence: None: All rights reserved

Centre for Musculoskeletal Ageing Research (linked to 18289 & 19482)
Lord, J. (Principal Investigator), Buckley, C. (Co-Investigator), Duda, J. (Co-Investigator), Dunn, W. (Co-Investigator), Miall, C. (Co-Investigator) & Greig, C. (Co-Investigator)
Medical Research Council
1/08/12 → 31/07/17
Project: Research Councils

Cite this

Wilmot, E. G., Leggate, M., Khan, J. N., Yates, T., Gorely, T., Bodicoat, D. H., Khunti, K., Kuijer, J. P. A., Gray, L. J., Singh, A., Clarysse, P., Croisille, P., Nimmo, M. A., McCann, G. P., & Davies, M. J. (2014). Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction. Diabetic Medicine, 31(7), 794-798. https://doi.org/10.1111/dme.12431

@article{710c657db98841c1ab333892f3631c5d,

title = "Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction",

abstract = "AIM: A pilot study to phenotype young adults (< 40 years) with Type 2 diabetes mellitus.METHODS: Twenty people with Type 2 diabetes (aged 18-40 years), 10 lean and 10 obese control subjects underwent detailed assessment, including tagged cardiac magnetic resonance imaging, inflammatory proteins, lipids, vitamin D and maximal oxygen uptake. Outcomes were compared between the group with Type 2 diabetes and the control group.RESULTS: Mean (standard deviation) age, Type 2 diabetes duration and BMI in the group with Type 2 diabetes were 31.8 (6.6) years, 4.7 (4.0) years and 33.9 (5.8) kg/m(2) respectively. Compared with lean control subjects, those with Type 2 diabetes had more deleterious profiles of hyperlipidaemia, vitamin D deficiency, inflammation and maximal oxygen uptake relative to body mass. However, there was no difference between the group with Type 2 diabetes and the obese control group. The group with Type 2 diabetes had a higher left ventricular mass and a trend towards concentric remodelling compared with the lean control group (P = 0.002, P = 0.052) but not the obese control group (P > 0.05). Peak early diastolic strain rate was reduced in the group with Type 2 diabetes [1.51 (0.24)/s] compared with the lean control [1.97 (0.34)/s, P = 0.001] and obese control [1.78 (0.39)/s, P = 0.042] group.CONCLUSIONS: Young adults with Type 2 diabetes and those with obesity have similar adverse cardiovascular risk profiles, higher left ventricular mass and a trend towards left ventricular concentric remodelling. In addition, those with Type 2 diabetes demonstrate diastolic dysfunction, a known risk marker for future heart failure and mortality.",

author = "Wilmot, {E G} and M Leggate and Khan, {J N} and T Yates and T Gorely and Bodicoat, {D H} and K Khunti and Kuijer, {J P A} and Gray, {L J} and A Singh and P Clarysse and P Croisille and Nimmo, {M A} and McCann, {G P} and Davies, {M J}",

note = "{\textcopyright} 2014 The Authors. Diabetic Medicine {\textcopyright} 2014 Diabetes UK.",

year = "2014",

month = jul,

doi = "10.1111/dme.12431",

language = "English",

volume = "31",

pages = "794--798",

journal = "Diabetic Medicine",

issn = "0742-3071",

publisher = "Wiley",

number = "7",

}

Wilmot, EG, Leggate, M, Khan, JN, Yates, T, Gorely, T, Bodicoat, DH, Khunti, K, Kuijer, JPA, Gray, LJ, Singh, A, Clarysse, P, Croisille, P, Nimmo, MA, McCann, GP & Davies, MJ 2014, 'Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction', Diabetic Medicine, vol. 31, no. 7, pp. 794-798. https://doi.org/10.1111/dme.12431

TY - JOUR

T1 - Type 2 diabetes mellitus and obesity in young adults

T2 - the extreme phenotype with early cardiovascular dysfunction

AU - Wilmot, E G

AU - Leggate, M

AU - Khan, J N

AU - Yates, T

AU - Gorely, T

AU - Bodicoat, D H

AU - Khunti, K

AU - Kuijer, J P A

AU - Gray, L J

AU - Singh, A

AU - Clarysse, P

AU - Croisille, P

AU - Nimmo, M A

AU - McCann, G P

AU - Davies, M J

PY - 2014/7

Y1 - 2014/7

N2 - AIM: A pilot study to phenotype young adults (< 40 years) with Type 2 diabetes mellitus.METHODS: Twenty people with Type 2 diabetes (aged 18-40 years), 10 lean and 10 obese control subjects underwent detailed assessment, including tagged cardiac magnetic resonance imaging, inflammatory proteins, lipids, vitamin D and maximal oxygen uptake. Outcomes were compared between the group with Type 2 diabetes and the control group.RESULTS: Mean (standard deviation) age, Type 2 diabetes duration and BMI in the group with Type 2 diabetes were 31.8 (6.6) years, 4.7 (4.0) years and 33.9 (5.8) kg/m(2) respectively. Compared with lean control subjects, those with Type 2 diabetes had more deleterious profiles of hyperlipidaemia, vitamin D deficiency, inflammation and maximal oxygen uptake relative to body mass. However, there was no difference between the group with Type 2 diabetes and the obese control group. The group with Type 2 diabetes had a higher left ventricular mass and a trend towards concentric remodelling compared with the lean control group (P = 0.002, P = 0.052) but not the obese control group (P > 0.05). Peak early diastolic strain rate was reduced in the group with Type 2 diabetes [1.51 (0.24)/s] compared with the lean control [1.97 (0.34)/s, P = 0.001] and obese control [1.78 (0.39)/s, P = 0.042] group.CONCLUSIONS: Young adults with Type 2 diabetes and those with obesity have similar adverse cardiovascular risk profiles, higher left ventricular mass and a trend towards left ventricular concentric remodelling. In addition, those with Type 2 diabetes demonstrate diastolic dysfunction, a known risk marker for future heart failure and mortality.

AB - AIM: A pilot study to phenotype young adults (< 40 years) with Type 2 diabetes mellitus.METHODS: Twenty people with Type 2 diabetes (aged 18-40 years), 10 lean and 10 obese control subjects underwent detailed assessment, including tagged cardiac magnetic resonance imaging, inflammatory proteins, lipids, vitamin D and maximal oxygen uptake. Outcomes were compared between the group with Type 2 diabetes and the control group.RESULTS: Mean (standard deviation) age, Type 2 diabetes duration and BMI in the group with Type 2 diabetes were 31.8 (6.6) years, 4.7 (4.0) years and 33.9 (5.8) kg/m(2) respectively. Compared with lean control subjects, those with Type 2 diabetes had more deleterious profiles of hyperlipidaemia, vitamin D deficiency, inflammation and maximal oxygen uptake relative to body mass. However, there was no difference between the group with Type 2 diabetes and the obese control group. The group with Type 2 diabetes had a higher left ventricular mass and a trend towards concentric remodelling compared with the lean control group (P = 0.002, P = 0.052) but not the obese control group (P > 0.05). Peak early diastolic strain rate was reduced in the group with Type 2 diabetes [1.51 (0.24)/s] compared with the lean control [1.97 (0.34)/s, P = 0.001] and obese control [1.78 (0.39)/s, P = 0.042] group.CONCLUSIONS: Young adults with Type 2 diabetes and those with obesity have similar adverse cardiovascular risk profiles, higher left ventricular mass and a trend towards left ventricular concentric remodelling. In addition, those with Type 2 diabetes demonstrate diastolic dysfunction, a known risk marker for future heart failure and mortality.

U2 - 10.1111/dme.12431

DO - 10.1111/dme.12431

M3 - Article

C2 - 24606573

SN - 0742-3071

VL - 31

SP - 794

EP - 798

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 7

ER -

Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction

Abstract

Bibliographical note

UN SDGs

Access to Document

Fingerprint

Projects

Centre for Musculoskeletal Ageing Research (linked to 18289 & 19482)

Cite this