Type 1 and 5 secretion systems and associated toxins

Timothy J. Wells*, Ian R. Henderson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)


Many virulence factors of Escherichia coli need to traverse the inner membrane, periplasm, and outer membrane to be effective. The bacterium has a variety of secretion systems to achieve this. Two of these, the type I secretion system (T1SS) and the type V secretion system (T5SS), are explored in this chapter. In E. coli the best-known T1SS is that used to secrete hemolysin, a pore-forming toxin found in both uropathogenic and enterohemorrhagic strains of E. coli. Many proteins are secreted via the T5SS in E. coli, with the proteins having a wide range of virulence functions. This chapter will focus on these two systems; the mechanism of biogenesis, the function of the secreted proteins and current attempts to use these systems in biotechnological applications.

Original languageEnglish
Title of host publicationEscherichia coli
Subtitle of host publicationPathotypes and Principles of Pathogenesis: Second Edition
Number of pages34
ISBN (Print)9780123970480
Publication statusPublished - 5 Aug 2013


  • Autotransporter
  • Hemolysin
  • T1SS
  • T5SS
  • Trimeric autotransporter adhesin
  • Two-partner secretion

ASJC Scopus subject areas

  • General Immunology and Microbiology


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