Two proteins act as the IUF1 insulin gene enhancer binding factor

Valerie Scott, Andrew R. Clark, John C. Hutton, Kevin Docherty

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

IUF1 is a pancreatic β cell-specific factor which binds to the sequence 5′-CPyCTAATG-3′ (CT box) within the human insulin gene enhancer. Here we show that IUF1 is composed of 2 binding activities that can be separated by DEAE ion exchange chromatography. South Western blot analysis indicates that these distinct binding activities have apparent molecular weights of 115 kDa and 46 kDa.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalFEBS Letters
Volume290
Issue number1-2
DOIs
Publication statusPublished - 23 Sep 1991

Keywords

  • Gene expression
  • Insulin gene
  • Transcription factor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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