Abstract
We present the findings of a study of two large unrelated kindreds with autosomal dominant Parkinson's disease. The affected members were assessed clinically and with [(18)F]6-fluorodopa-PET and were indistinguishable from patients with the sporadic form of Parkinson's disease. In one kindred, an affected member was examined subsequently at autopsy and Lewy bodies were present in a distribution typical of sporadic Parkinson's disease. These kindreds are distinct from other Parkinsonian kindreds with identified genetic loci (PARK1-4) and provide further evidence for genetic heterogeneity in familial Parkinson's disease.
Original language | English |
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Pages (from-to) | 44-57 |
Number of pages | 14 |
Journal | Brain |
Volume | 125 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2002 |