Abstract
Simultaneous overexpression of MexAB-OprM and MexEF-OprN was demonstrated for a multiply antibiotic-resistant clinical isolate of Pseudomonas aeruginosa (G49). G49 also had decreased expression of OprF. No mutations in mexR or its upstream promoter region, mexT, oprM, oprF, or sigX were revealed, suggesting regulation by a hitherto undescribed locus.
| Original language | English |
|---|---|
| Pages (from-to) | 2861-4 |
| Number of pages | 4 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 44 |
| Issue number | 10 |
| Publication status | Published - Oct 2000 |
Keywords
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Blotting, Western
- Carrier Proteins
- Drug Resistance, Multiple
- Electrophoresis, Polyacrylamide Gel
- Membrane Transport Proteins
- Mutation
- Phenotype
- Porins
- Promoter Regions, Genetic
- Pseudomonas aeruginosa