Projects per year
Abstract
Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades of bacterial genome sequencing, which have been marked by three revolutions: whole-genome shotgun sequencing, high-throughput sequencing and single-molecule long-read sequencing. We summarize the social history of sequencing and its impact on our understanding of the biology, diversity and evolution of bacteria, while also highlighting spin-offs and translational impact in the clinic. We look forward to a 'sequencing singularity', where sequencing becomes the method of choice for as-yet unthinkable applications in bacteriology and beyond.
Original language | English |
---|---|
Pages (from-to) | 787-794 |
Number of pages | 8 |
Journal | Nature Reviews Microbiology |
Volume | 13 |
Early online date | 9 Nov 2015 |
DOIs | |
Publication status | Published - Dec 2015 |
Keywords
- DNA, Bacterial
- Genome, Bacterial
- History, 20th Century
- History, 21st Century
- Humans
- Molecular Epidemiology
- Molecular Typing
- Sequence Analysis, DNA
- Historical Article
- Journal Article
- Research Support, Non-U.S. Gov't
Fingerprint
Dive into the research topics of 'Twenty years of bacterial genome sequencing'. Together they form a unique fingerprint.Projects
- 2 Finished
-
Development of robust analytical pipelines for the analysis of microbial community data from clinical samples
1/09/12 → 31/08/15
Project: Research Councils
-
xBASE: A bioinformatics resource for the AgriFood Bacteriology Community
Pallen, M. & Stekel, D.
Biotechnology & Biological Sciences Research Council
1/02/07 → 31/01/12
Project: Research Councils