TY - JOUR
T1 - Tumour necrosis factor-α in Barrett's oesophagus: A potential novel mechanism of action
AU - Tselepis, Chris
AU - Perry, Ian
AU - Dawson, Christopher
AU - Hardy, Robert
AU - Darnton, SJ
AU - McConkey, Christopher
AU - Stuart, RC
AU - Wright, N
AU - Harrison, R
AU - Jankowski, Janusz
PY - 2002/9/5
Y1 - 2002/9/5
N2 - Barrett's metaplasia (BM) is an early lesion in the progression from oesophageal inflammation through dysplasia to the development of Barrett's adenocarcinoma (BA). Previous work indicates that BM and BA are associated with reduced E-cadherin expression and increased cytoplasmic/nuclear pools of its associated protein beta-catenin. beta-catenin participates in Wnt signalling and activates oncogene transcription by complexing with T-cells factors (TCF). One such oncogene is c-myc. We have previously shown that TNF-alpha can down-regulate E-cadherin expression. Here, we assess TNF-alpha expression in Barrett's metaplasia and examine if TNF-alpha can promote beta-catenin mediated transcription of oncogenes in a gastrointestinal model system. Employing immunohistochemistry and Western blot analysis of oesophageal tissue, epithelial expression of TNF-alpha increases with progression along the metaplasia-dysplasia-carcinoma sequence (P
AB - Barrett's metaplasia (BM) is an early lesion in the progression from oesophageal inflammation through dysplasia to the development of Barrett's adenocarcinoma (BA). Previous work indicates that BM and BA are associated with reduced E-cadherin expression and increased cytoplasmic/nuclear pools of its associated protein beta-catenin. beta-catenin participates in Wnt signalling and activates oncogene transcription by complexing with T-cells factors (TCF). One such oncogene is c-myc. We have previously shown that TNF-alpha can down-regulate E-cadherin expression. Here, we assess TNF-alpha expression in Barrett's metaplasia and examine if TNF-alpha can promote beta-catenin mediated transcription of oncogenes in a gastrointestinal model system. Employing immunohistochemistry and Western blot analysis of oesophageal tissue, epithelial expression of TNF-alpha increases with progression along the metaplasia-dysplasia-carcinoma sequence (P
KW - tumour necrosis factor-alpha (TNF-alpha)
KW - cadherins and catenins
KW - cancer
KW - Barrett's oesophagus
UR - http://www.scopus.com/inward/record.url?scp=18544367202&partnerID=8YFLogxK
U2 - 10.1038/sj.onc.1205731
DO - 10.1038/sj.onc.1205731
M3 - Article
C2 - 12203119
VL - 21
SP - 6071
EP - 6081
JO - Oncogene
JF - Oncogene
IS - 39
ER -