Tubulin-guided dynamic combinatorial library of thiocolchicine-podophyllotoxin conjugates

G Cappelletti, D Cartelli, B Peretto, M Ventura, M Riccioli, F Colombo, John Snaith, S Borrelli, D Passarella

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The use of tubulin as a target to influence the composition of the mixture from a dynamic combinatorial library, based on the disulfide bond exchange reaction, is described. ESI-FT-ICR-MS was used to determine the composition of the library. The heterodimeric compound amplified by this approach was used to design the homologous derivative with a two-carbon spacer in place of the disulfide function. The ability of the compounds to inhibit tubulin polymerization is reported and compared to thiocolchicine. (C) 2011 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)7354-7357
Number of pages4
JournalTetrahedron
Volume67
Issue number38
DOIs
Publication statusPublished - 1 Sep 2011

Keywords

  • Dynamic combinatorial chemistry
  • Target-guided synthesis
  • Disulfide-exchange reaction

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