Tropomyosins: potential biomarkers for Urothelial Bladder Cancer

Nada Humayun-Zakaria; Roland Arnold; Anshita Goel; Douglas Ward; Stuart Savill; Richard Bryan

doi:10.3390/ijms20051102

Tropomyosins: potential biomarkers for Urothelial Bladder Cancer

Nada Humayun-Zakaria, Roland Arnold, Anshita Goel, Douglas Ward, Stuart Savill, Richard Bryan

Cancer and Genomic Sciences

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

182 Downloads (Pure)

Abstract

Despite the incidence and prevalence of urothelial bladder cancer (UBC), few advances in treatment and diagnosis have been made in recent years. In this review, we discuss potential biomarker candidates: the tropomyosin family of genes, encoded by four loci in the human genome. The expression of these genes is tissue-specific. Tropomyosins are responsible for diverse cellular roles, most notably based upon their interplay with actin to maintain cellular processes, integrity and structure. Tropomyosins exhibit a large variety of splice forms, and altered isoform expression levels have been associated with cancer, including UBC. Notably, tropomyosin isoforms are detectable in urine, offering the potential for non-invasive diagnosis and risk-stratification. This review collates the basic knowledge on tropomyosin and its isoforms, and discusses their relationships with cancer-related phenomena, most specifically in UBC

Original language	English
Article number	1102
Number of pages	14
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	5
DOIs	https://doi.org/10.3390/ijms20051102
Publication status	Published - 4 Mar 2019

Bibliographical note

Funding Information:
Funding: N Humayun-Zakaria’s research is funded by QEHB Charities.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

tropomyosin
TPM
urothelial bladder cancer
NMIBC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijms20051102

Nada_Humayun-Zakaria_et_al_Tropomyosins_International_Journal_of_Molecular_Sciences_2019
Checked for eligibility: 05/03/2019
Final published version, 724 KBLicence: Creative Commons: Attribution (CC BY)

https://www.mdpi.com/1422-0067/20/5/1102Licence: Creative Commons: Attribution (CC BY)

Bladder Cancer Prognosis Programme
Bryan, R.
NIHR
1/05/10 → 31/07/13
Project: Other Government Departments

Birmingham Environment for Academic Research (BEAR)
Facility/equipment: Equipment

Cite this

@article{1a7a6e7679ce4e56b4a0e13acb319d90,

title = "Tropomyosins: potential biomarkers for Urothelial Bladder Cancer",

abstract = "Despite the incidence and prevalence of urothelial bladder cancer (UBC), few advances in treatment and diagnosis have been made in recent years. In this review, we discuss potential biomarker candidates: the tropomyosin family of genes, encoded by four loci in the human genome. The expression of these genes is tissue-specific. Tropomyosins are responsible for diverse cellular roles, most notably based upon their interplay with actin to maintain cellular processes, integrity and structure. Tropomyosins exhibit a large variety of splice forms, and altered isoform expression levels have been associated with cancer, including UBC. Notably, tropomyosin isoforms are detectable in urine, offering the potential for non-invasive diagnosis and risk-stratification. This review collates the basic knowledge on tropomyosin and its isoforms, and discusses their relationships with cancer-related phenomena, most specifically in UBC",

keywords = "tropomyosin, TPM, urothelial bladder cancer, NMIBC",

author = "Nada Humayun-Zakaria and Roland Arnold and Anshita Goel and Douglas Ward and Stuart Savill and Richard Bryan",

note = "Funding Information: Funding: N Humayun-Zakaria{\textquoteright}s research is funded by QEHB Charities. Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2019",

month = mar,

day = "4",

doi = "10.3390/ijms20051102",

language = "English",

volume = "20",

journal = "International Journal of Molecular Sciences",

issn = "1422-0067",

publisher = "MDPI",

number = "5",

}

TY - JOUR

T1 - Tropomyosins

T2 - potential biomarkers for Urothelial Bladder Cancer

AU - Humayun-Zakaria, Nada

AU - Arnold, Roland

AU - Goel, Anshita

AU - Ward, Douglas

AU - Savill, Stuart

AU - Bryan, Richard

N1 - Funding Information: Funding: N Humayun-Zakaria’s research is funded by QEHB Charities. Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/3/4

Y1 - 2019/3/4

N2 - Despite the incidence and prevalence of urothelial bladder cancer (UBC), few advances in treatment and diagnosis have been made in recent years. In this review, we discuss potential biomarker candidates: the tropomyosin family of genes, encoded by four loci in the human genome. The expression of these genes is tissue-specific. Tropomyosins are responsible for diverse cellular roles, most notably based upon their interplay with actin to maintain cellular processes, integrity and structure. Tropomyosins exhibit a large variety of splice forms, and altered isoform expression levels have been associated with cancer, including UBC. Notably, tropomyosin isoforms are detectable in urine, offering the potential for non-invasive diagnosis and risk-stratification. This review collates the basic knowledge on tropomyosin and its isoforms, and discusses their relationships with cancer-related phenomena, most specifically in UBC

AB - Despite the incidence and prevalence of urothelial bladder cancer (UBC), few advances in treatment and diagnosis have been made in recent years. In this review, we discuss potential biomarker candidates: the tropomyosin family of genes, encoded by four loci in the human genome. The expression of these genes is tissue-specific. Tropomyosins are responsible for diverse cellular roles, most notably based upon their interplay with actin to maintain cellular processes, integrity and structure. Tropomyosins exhibit a large variety of splice forms, and altered isoform expression levels have been associated with cancer, including UBC. Notably, tropomyosin isoforms are detectable in urine, offering the potential for non-invasive diagnosis and risk-stratification. This review collates the basic knowledge on tropomyosin and its isoforms, and discusses their relationships with cancer-related phenomena, most specifically in UBC

KW - tropomyosin

KW - TPM

KW - urothelial bladder cancer

KW - NMIBC

UR - http://www.scopus.com/inward/record.url?scp=85062631833&partnerID=8YFLogxK

U2 - 10.3390/ijms20051102

DO - 10.3390/ijms20051102

M3 - Review article

C2 - 30836651

SN - 1422-0067

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 5

M1 - 1102

ER -

Tropomyosins: potential biomarkers for Urothelial Bladder Cancer

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Fingerprint

Projects

Bladder Cancer Prognosis Programme

Equipment

Birmingham Environment for Academic Research (BEAR)

Cite this