Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways

S El-Ghaiesh; JP Sanderson; J Farrell; SN Lavergne; Wing-Kin Syn; M Pirmohamed; BK Park; DJ Naisbitt

doi:10.1021/tx2001256

Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways

S El-Ghaiesh, JP Sanderson, J Farrell, SN Lavergne, Wing-Kin Syn, M Pirmohamed, BK Park, DJ Naisbitt

Immunology and Immunotherapy

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Pathways of drug-specific T-cell stimulation have not been fully defined. The aim of this study was to use T-cell clones from a patient hypersensitive to the drug trimethoprim to characterize the involvement of drug metabolism and processing in antigen presentation and cross-reactivity patterns. The MHC-restricted CD4+ and CD8+ T-cell response was dependent on the presence of antigen-presenting cells, and both processing-dependent and -independent pathways of antigen presentation were detected. Stimulation of certain clones was blocked through inhibition of drug-metabolizing enzyme activity. Trimethoprim clones were additionally stimulated with diaveridine and pyrimethamine but not other closely related structures.

Original language	English
Pages (from-to)	791-793
Number of pages	3
Journal	Chemical Research in Toxicology
Volume	24
Issue number	6
DOIs	https://doi.org/10.1021/tx2001256
Publication status	Published - 1 Jun 2011

Access to Document

10.1021/tx2001256

Cite this

@article{0b97c0e97b0b4371ad8c1d2096a7dce4,

title = "Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways",

abstract = "Pathways of drug-specific T-cell stimulation have not been fully defined. The aim of this study was to use T-cell clones from a patient hypersensitive to the drug trimethoprim to characterize the involvement of drug metabolism and processing in antigen presentation and cross-reactivity patterns. The MHC-restricted CD4+ and CD8+ T-cell response was dependent on the presence of antigen-presenting cells, and both processing-dependent and -independent pathways of antigen presentation were detected. Stimulation of certain clones was blocked through inhibition of drug-metabolizing enzyme activity. Trimethoprim clones were additionally stimulated with diaveridine and pyrimethamine but not other closely related structures.",

author = "S El-Ghaiesh and JP Sanderson and J Farrell and SN Lavergne and Wing-Kin Syn and M Pirmohamed and BK Park and DJ Naisbitt",

year = "2011",

month = jun,

day = "1",

doi = "10.1021/tx2001256",

language = "English",

volume = "24",

pages = "791--793",

journal = "Chemical Research in Toxicology",

issn = "0893-228X",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways

AU - El-Ghaiesh, S

AU - Sanderson, JP

AU - Farrell, J

AU - Lavergne, SN

AU - Syn, Wing-Kin

AU - Pirmohamed, M

AU - Park, BK

AU - Naisbitt, DJ

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Pathways of drug-specific T-cell stimulation have not been fully defined. The aim of this study was to use T-cell clones from a patient hypersensitive to the drug trimethoprim to characterize the involvement of drug metabolism and processing in antigen presentation and cross-reactivity patterns. The MHC-restricted CD4+ and CD8+ T-cell response was dependent on the presence of antigen-presenting cells, and both processing-dependent and -independent pathways of antigen presentation were detected. Stimulation of certain clones was blocked through inhibition of drug-metabolizing enzyme activity. Trimethoprim clones were additionally stimulated with diaveridine and pyrimethamine but not other closely related structures.

AB - Pathways of drug-specific T-cell stimulation have not been fully defined. The aim of this study was to use T-cell clones from a patient hypersensitive to the drug trimethoprim to characterize the involvement of drug metabolism and processing in antigen presentation and cross-reactivity patterns. The MHC-restricted CD4+ and CD8+ T-cell response was dependent on the presence of antigen-presenting cells, and both processing-dependent and -independent pathways of antigen presentation were detected. Stimulation of certain clones was blocked through inhibition of drug-metabolizing enzyme activity. Trimethoprim clones were additionally stimulated with diaveridine and pyrimethamine but not other closely related structures.

U2 - 10.1021/tx2001256

DO - 10.1021/tx2001256

M3 - Article

C2 - 21491947

SN - 0893-228X

VL - 24

SP - 791

EP - 793

JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

IS - 6

ER -

Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways

Abstract

Access to Document

Fingerprint

Cite this