TY - JOUR
T1 - Tricorn-like proteases in bacteria
AU - Pallen, Mark
AU - Lam, AC
AU - Loman, N
PY - 2001/11/1
Y1 - 2001/11/1
N2 - The tricorn protease is an archaeal protease that forms massive proteasome-like capsids with a hollow chamber. beta-Propeller and PDZ domains are thought to play a role in substrate selection. By analysis of predicted proteins from novel bacterial genome sequences, we have identified four new bacterial tricorn-like proteases, complete with similar beta-propeller, PDZ and catalytic domains. We propose various hypotheses as to the function of these domains that can now be tested in the laboratory.
AB - The tricorn protease is an archaeal protease that forms massive proteasome-like capsids with a hollow chamber. beta-Propeller and PDZ domains are thought to play a role in substrate selection. By analysis of predicted proteins from novel bacterial genome sequences, we have identified four new bacterial tricorn-like proteases, complete with similar beta-propeller, PDZ and catalytic domains. We propose various hypotheses as to the function of these domains that can now be tested in the laboratory.
UR - http://www.scopus.com/inward/record.url?scp=0035520383&partnerID=8YFLogxK
U2 - 10.1016/S0966-842X(01)02199-0
DO - 10.1016/S0966-842X(01)02199-0
M3 - Article
C2 - 11825690
VL - 9
SP - 518
EP - 521
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 11
ER -