Tricorn-like proteases in bacteria

Mark Pallen, AC Lam, N Loman

Research output: Contribution to journalArticle

6 Citations (Scopus)


The tricorn protease is an archaeal protease that forms massive proteasome-like capsids with a hollow chamber. beta-Propeller and PDZ domains are thought to play a role in substrate selection. By analysis of predicted proteins from novel bacterial genome sequences, we have identified four new bacterial tricorn-like proteases, complete with similar beta-propeller, PDZ and catalytic domains. We propose various hypotheses as to the function of these domains that can now be tested in the laboratory.
Original languageEnglish
Pages (from-to)518-21
Number of pages4
JournalTrends in Microbiology
Issue number11
Publication statusPublished - 1 Nov 2001


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