Treatment of erosive oral lichen planus with topical tacrolimus

MA Thomson, John Hamburger, DG Stewart, HM Lewis

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

BACKGROUND: Erosive oral lichen planus (LP) is a painful chronic inflammatory condition that is frequently resistant to immunosuppressive agents. Topical tacrolimus has been reported as a safe and effective treatment. OBJECTIVE: To evaluate the efficacy and safety of topical tacrolimus in the treatment of symptomatic erosive oral LP. METHODS: A retrospective review of consecutive patients with oral LP treated with topical tacrolimus between June 1999 and November 2003 was performed. Clinical improvement and adverse events were recorded by the physician. Patients were asked retrospectively to rate their symptoms immediately prior to and after tacrolimus therapy using a visual analogue scale. RESULTS: Physician-observed clinical improvement was found in 21 of 23 patients (91.3%) within 6 weeks. Six patients (26.1%) remained asymptomatic after stopping treatment and 15 patients (65.2%) required maintenance therapy to prevent subsequent flares. Patients' self-reported symptom scores were significantly better (p
Original languageEnglish
Pages (from-to)308-314
Number of pages7
JournalJournal of Dermatological Treatment
Volume15
DOIs
Publication statusPublished - 1 Sep 2004

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