Transplanting human infant gut microbiome species into Galleria mellonella

Harriet C C Gooch, Marjorie Labedan, Lindsay J Hall, Anthony Maxwell

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Abstract

OBJECTIVE: Study of the human infant gut microbiome requires the use of surrogate mammalian species such as mice. We sought to investigate the usefulness of the greater wax moth larva, Galleria mellonella, as an alternative.

RESULTS: We have analysed the native gut microbiome of Galleria and developed methods for clearing the native microbiome and introducing species from human infant faecal samples. We find that some species, e.g. enterococci, are more successful at recolonisation, but that others, e.g. Bifidobacterium, are less so. The work paves the way for using Galleria rather than mice in this and similar work.

Original languageEnglish
Article number123
JournalBMC Research Notes
Volume17
Issue number1
DOIs
Publication statusPublished - 30 Apr 2024

Bibliographical note

© 2024. The Author(s).

Keywords

  • Animals
  • Gastrointestinal Microbiome/physiology
  • Humans
  • Moths/microbiology
  • Larva/microbiology
  • Infant
  • Feces/microbiology
  • Bifidobacterium/isolation & purification
  • Enterococcus/isolation & purification

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